Interesting facts
Interesting Facts about 1-butyl-3-(p-tolylsulfonyl)urea
1-butyl-3-(p-tolylsulfonyl)urea is a compound that belongs to the class of urea derivatives, which are often recognized for their biological and chemical significance. Here are some engaging insights into this fascinating compound:
- Pharmaceutical Potential: Compounds similar to 1-butyl-3-(p-tolylsulfonyl)urea have often been investigated for their potential as pharmaceuticals, particularly in the field of drug development. Their unique structure can interact with biological targets, making them candidates for various therapeutic applications.
- Structural Components: The presence of both butyl and p-tolylsulfonyl groups in its structure contributes to unique properties. The butyl group can influence the hydrophobicity of the molecule, while the p-tolylsulfonyl group can enhance solubility and interaction profiles.
- Versatile Applications: This compound may find applications beyond pharmaceuticals. Its unique chemical structure makes it useful in agrochemicals, dyes, and possibly in the development of various materials, showcasing its versatility.
- Synthetic Routes: The synthesis of urea derivatives like this one often involves multi-step organic reactions, which can serve as a gateway for learning about reaction mechanisms and strategies in synthetic organic chemistry.
- Intermolecular Interactions: The interactions due to the sulfonyl group can enhance the compound's ability to form hydrogen bonds, which can greatly affect its reactivity and interaction in biological systems.
As a scientist or student, studying compounds like 1-butyl-3-(p-tolylsulfonyl)urea opens a window into the multifaceted nature of chemistry, showing how the slight modification of a molecular structure can lead to drastically different properties and functions. As the famed chemist Linus Pauling once said, "The best way to have a good idea is to have a lot of ideas." This mindset encourages exploration and innovation in chemical science.
Synonyms
tolbutamide
64-77-7
Orinase
Arkozal
Willbutamide
Butamide
Diabetamid
Ipoglicone
Glyconon
Rastinon
Tolbutamid
Aglicid
Artosin
Diaben
Tolumid
1-Butyl-3-tosylurea
Diasulfon
Artozin
Butamid
Diabetol
Diabuton
Dirastan
Dolipol
Mobenol
Oterben
Pramidex
Tolbusal
Toluina
Toluvan
Tolylsulfonylbutylurea
1-Butyl-3-(p-tolylsulfonyl)urea
Drabet
Orabet
Oralin
Orezan
Orinaz
Tolbutamidum
Tolbutamida
Sk-tolbutamide
N-n-Butyl-N'-tosylurea
N-(Butylcarbamoyl)-4-methylbenzenesulfonamide
1-p-Toluenesulfonyl-3-butylurea
1-Butyl-3-(p-methylphenylsulfonyl)urea
Arcosal
Beglucin
Butamidum
Diabesan
N-Butyl-N'-(p-tolylsulfonyl)urea
Tarasina
Tolbutone
Tolbet
N-Butyl-N'-p-toluenesulfonylurea
3-(p-Tolyl-4-sulfonyl)-1-butylurea
N-(4-Methylphenylsulfonyl)-N'-butylurea
N-Butyl-N'-(4-methylphenylsulfonyl)urea
N-(4-Methylbenzenesulfonyl)-N'-butylurea
HLS 831
N-(Sulfonyl-p-methylbenzene)-N'-N-butylurea
Orinase (TN)
Tolumide
N-(p-Tolylsulfonyl)-N'-butylcarbamide
1-butyl-3-(4-methylphenyl)sulfonylurea
NCI-C01763
N-4-Methylbenzolsulfonyl-N-butylurea
Urea, 1-butyl-3-(p-tolylsulfonyl)-
D 860
Tolbutamidum [INN-Latin]
1-Butyl-3-(4-methylphenylsulfonyl)urea
Benzenesulfonamide, N-[(butylamino)carbonyl]-4-methyl-
Tolbutamida [INN-Spanish]
N-Butyl-N'-toluene-p-sulfonylurea
CCRIS 592
MFCD00027169
N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide
N-4-(Methylbenzolsulfonyl)-n-butylurea
HSDB 3393
N-(p-Methylbenzenesulfonyl)-N'-butylurea
UNII-982XCM1FOI
EINECS 200-594-3
982XCM1FOI
NSC 23813
NSC-23813
U 2043
BRN 1984428
3-butyl-1-(4-methylbenzenesulfonyl)urea
DTXSID8021359
CHEBI:27999
N-(Sulfonyl-p-methylbenzene)-N'-butylurea
3-butyl-1-[(4-methylbenzene)sulfonyl]urea
Benzenesulfonamide, N-((butylamino)carbonyl)-4-methyl-
NSC-87833
1-BUTYL-3-(4-METHYLBENZENESULFONYL)UREA
CHEMBL782
N-((Butylamino)carbonyl)-4-methylbenzenesulfonamide
MLS000028399
DTXCID801359
Tolbutamide [USP:INN:BAN:JAN]
4-11-00-00396 (Beilstein Handbook Reference)
CAS-64-77-7
toluran
NCGC00015999-10
SMR000058363
Tolbutamide form I^L^
Tolbutamidum (INN-Latin)
Tolbutamida (INN-Spanish)
TOLBUTAMIDE (MART.)
TOLBUTAMIDE [MART.]
TOLBUTAMIDE (USP-RS)
TOLBUTAMIDE [USP-RS]
TOLBUTAMIDE (EP MONOGRAPH)
Tolbutamide (USP:INN:BAN:JAN)
TOLBUTAMIDE [EP MONOGRAPH]
TOLBUTAMIDE (USP MONOGRAPH)
TOLBUTAMIDE [USP MONOGRAPH]
SR-01000003059
tolbutamide IL
tolbutamide III
Prestwick_471
Spectrum_000447
Tolbutamide (Standard)
Tolbutamide form I^H^
Opera_ID_112
TOLBUTAMIDE [MI]
Prestwick0_000190
Prestwick1_000190
Prestwick2_000190
Prestwick3_000190
Spectrum2_001210
Spectrum3_000599
Spectrum4_000358
Spectrum5_001272
Lopac-T-0891
TOLBUTAMIDE [INN]
TOLBUTAMIDE [JAN]
N-n-Butyl-N''-tosylurea
TOLBUTAMIDE [HSDB]
WLN: 4MVMSWR D1
T 0891
TOLBUTAMIDE [VANDF]
NCIOpen2_009592
BIDD:PXR0179
CBiol_001920
Lopac0_001154
SCHEMBL15918
BSPBio_000119
BSPBio_001507
BSPBio_002078
KBioGR_000227
KBioGR_000795
KBioGR_002275
KBioSS_000227
KBioSS_000927
KBioSS_002276
TOLBUTAMIDE [WHO-DD]
TOLBUTAMIDE [WHO-IP]
MLS001148399
MLS002152944
DivK1c_000341
SPECTRUM1500581
Tolbutamide (JAN/USP/INN)
SPBio_001000
SPBio_002040
BPBio1_000131
GTPL6848
Tolbutamide, analytical standard
HMS501B03
HY-B0401R
KBio1_000341
KBio2_000227
KBio2_000927
KBio2_002275
KBio2_002795
KBio2_003495
KBio2_004843
KBio2_005363
KBio2_006063
KBio2_007411
KBio3_000453
KBio3_000454
KBio3_001578
KBio3_002755
A10BB03
MSK7197
TOLBUTAMIDE [ORANGE BOOK]
V04CA01
cMAP_000008
NINDS_000341
Bio1_000206
Bio1_000695
Bio1_001184
Bio2_000227
Bio2_000707
HMS1361L09
HMS1568F21
HMS1791L09
HMS1989L09
HMS2089C17
HMS2092M21
HMS2095F21
HMS2232H16
HMS3259A08
HMS3263H09
HMS3402L09
HMS3651N03
HMS3712F21
Pharmakon1600-01500581
BCP09192
HY-B0401
NSC23813
TOLBUTAMIDUM [WHO-IP LATIN]
N-Butyl-N''-(p-tolylsulfonyl)urea
Tox21_110279
Tox21_201612
Tox21_302795
Tox21_501154
BDBM50027886
CCG-39141
NSC757354
NSC813220
s2443
1-Butyl-3-(para-tolylsulfonyl)-urea
AKOS015894999
Tox21_110279_1
DB01124
FT28304
LP01154
NC00543
NSC-757354
NSC-813220
SDCCGSBI-0051121.P004
Tolbutamide 1.0 mg/ml in Acetonitrile
IDI1_000341
IDI1_033977
N-(n-Butyl)-N'-p-toluene-sulfonylurea
NCGC00015999-01
NCGC00015999-02
NCGC00015999-03
NCGC00015999-04
NCGC00015999-05
NCGC00015999-06
NCGC00015999-07
NCGC00015999-08
NCGC00015999-09
NCGC00015999-11
NCGC00015999-12
NCGC00015999-13
NCGC00015999-14
NCGC00015999-15
NCGC00015999-16
NCGC00015999-17
NCGC00015999-19
NCGC00015999-20
NCGC00015999-29
NCGC00022721-03
NCGC00022721-04
NCGC00022721-05
NCGC00022721-06
NCGC00022721-07
NCGC00022721-08
NCGC00022721-09
NCGC00022721-10
NCGC00256548-01
NCGC00259161-01
NCGC00261839-01
AC-12490
AS-14136
SY014891
N-(4-Methylphenylsulfonyl)-N''-butylurea
N-Butyl-N''-(4-methylphenylsulfonyl)urea
SBI-0051121.P003
DB-054728
AB00052110
EU-0101154
N-(P-TOLYLSULFONYL)N'-BUTYLCARBAMIDE
NS00001371
SW196681-3
T3690
BIM-0051121.0001
C07148
D00380
D87667
EN300-124678
U-2043
AB00052110-16
AB00052110_17
AB00052110_18
N'-4-METHYLBENZENESULFONYL-N''-BUTYLUREA
Tolbutamide, VETRANAL(TM), analytical standard
Q414275
SR-01000003059-2
SR-01000003059-4
SR-01000003059-7
BRD-K85119730-001-06-5
BRD-K85119730-001-17-2
BRD-K85119730-001-27-1
BRD-K85119730-001-28-9
Z44591715
Tolbutamide, European Pharmacopoeia (EP) Reference Standard
1-(([(Butylamino)carbonyl]amino)sulfonyl)-4-methylbenzene #
Tolbutamide, United States Pharmacopeia (USP) Reference Standard
200-594-3
N-[(Butylamino)carbonyl]-4-methyl-benzenesulfonamide;1-Butyl-3-(p-tolylsulfonyl)urea;Tolylsulfonylbutylurea
Solubility of 1-butyl-3-(p-tolylsulfonyl)urea (C12H18N2O3S)
The solubility of 1-butyl-3-(p-tolylsulfonyl)urea is influenced by several factors, including its polar and nonpolar characteristics. This compound features a urea moiety that can engage in hydrogen bonding, enhancing its solubility in polar solvents.
Solubility Characteristics:
To summarize, while 1-butyl-3-(p-tolylsulfonyl)urea may exhibit moderate solubility in water, its solubility improves significantly in organic solvents, making it quite versatile for various applications.
This highlights the essential balance between polar and nonpolar interactions that dictate its overall solubility profile.