Skip to main content

Flunarizine

ADVERTISEMENT
Identification
Molecular formula
C26H28F2N2
CAS number
52468-60-7
IUPAC name
1-[bis(4-fluorophenyl)methyl]-4-cinnamyl-piperazine
State
State
At room temperature, flunarizine is in a solid state, appearing as a fine, whitish powder.
Melting point (Celsius)
236.50
Melting point (Kelvin)
509.65
Boiling point (Celsius)
655.30
Boiling point (Kelvin)
928.45
General information
Molecular weight
474.57g/mol
Molar mass
474.5730g/mol
Density
1.2410g/cm3
Appearence

Flunarizine is typically a white to off-white crystalline powder. It is not soluble in water, giving it an opaque appearance when in mixed aqueous solutions.

Comment on solubility

Solubility of 1-[bis(4-fluorophenyl)methyl]-4-cinnamyl-piperazine

The solubility of the compound 1-[bis(4-fluorophenyl)methyl]-4-cinnamyl-piperazine, with the formula C26H28F2N2, can be influenced by several factors. This compound, characterized by its complex structure, reveals intriguing solubility properties. Here are some key points to consider:

  • Polarity: The presence of both fluorinated phenyl groups and the piperazine ring affects the overall polarity, which in turn influences solubility in various solvents.
  • Solvent Type: It is likely to be more soluble in non-polar or slightly polar organic solvents like dichloromethane or ethanol, as opposed to highly polar solvents like water.
  • Temperature Effects: As with many organic compounds, increasing temperature might enhance solubility due to increased molecular motion.
  • Concentration Dependency: Like many organic compounds, the solubility may adhere to the principles of saturation where a specific amount can dissolve in a solvent until no more can be incorporated.

As a pleasure to chemists, “solubility can often be the key to understanding the behavior of a compound in various formulations.” Therefore, determining the solubility of 1-[bis(4-fluorophenyl)methyl]-4-cinnamyl-piperazine is vital for applications in pharmaceutical and material sciences. The interplay of molecular structure and solvent characteristics makes studying such compounds both challenging and rewarding!

Interesting facts

Interesting Facts About 1-[bis(4-fluorophenyl)methyl]-4-cinnamyl-piperazine

The compound 1-[bis(4-fluorophenyl)methyl]-4-cinnamyl-piperazine is a fascinating chemical entity with notable properties and potential applications. Here are some intriguing aspects of this compound:

  • Diverse Applications: Compounds like this one are often studied for their potential in medicinal chemistry, particularly in the development of pharmacological agents. They can exhibit interesting biological activity that can be leveraged in drug development.
  • Fluorine's Role: The presence of fluorine atoms in its structure can significantly enhance the lipophilicity and metabolic stability of organic compounds. This property is essential in the design of pharmaceuticals, as it can improve the efficacy of a drug by aiding in its absorption and distribution within the body.
  • Complex Structure: The molecular design combines piperazine, a common motif in many bioactive compounds, with substituents from both the phenyl and cinnamyl groups. This complexity may contribute to the compound's unique interactions with biological targets.
  • Research Potential: Structures such as 1-[bis(4-fluorophenyl)methyl]-4-cinnamyl-piperazine are often explored in studies related to central nervous system disorders, given that piperazine derivatives can influence neurotransmitter systems.
  • Lead Compounds: This compound may serve as a lead structure, inspiring further analog development. Researchers often use similar frameworks to explore modifications that could enhance desired properties while minimizing side effects.

In summary, 1-[bis(4-fluorophenyl)methyl]-4-cinnamyl-piperazine is not merely a chemical formula, but a gateway to understanding the complex world of drug design, fluorine chemistry, and the therapeutic possibilities in medicinal science. As we continue to study such compounds, we inch closer to unlocking new treatments and therapies for various diseases.

Synonyms
(Z)-Flunarizine
1-[bis(4-fluorophenyl)methyl]-4-(3-phenylprop-2-en-1-yl)piperazine
1-[bis(4-fluorophenyl)methyl]-4-(3-phenylprop-2-enyl)piperazine
NCGC00018102-06
Spectrum_001208
Prestwick0_000312
Prestwick1_000312
Spectrum2_001382
Spectrum3_001418
Spectrum4_000827
CBiol_001758
Oprea1_381078
KBioGR_000061
KBioGR_001373
KBioSS_000061
KBioSS_001688
DivK1c_000043
SPBio_001364
SPBio_002523
CHEMBL3195822
KBio1_000043
KBio2_000061
KBio2_001688
KBio2_002629
KBio2_004256
KBio2_005197
KBio2_006824
KBio3_000121
KBio3_000122
KBio3_002316
DTXSID00860646
1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl](~2~H_8_)piperazine
NINDS_000043
Bio1_000044
Bio1_000533
Bio1_001022
Bio2_000061
Bio2_000541
120702-98-9
TCB76511
DB-052127
Q27163979