Interesting facts
Interesting Facts about 1-(azepan-1-yl)-3-(p-tolylsulfonyl)urea
1-(azepan-1-yl)-3-(p-tolylsulfonyl)urea is a fascinating compound in the realm of medicinal chemistry and organic synthesis. Here are some key points about this intriguing molecule:
- Pharmacological Potential: Compounds like 1-(azepan-1-yl)-3-(p-tolylsulfonyl)urea have garnered attention for their potential use in drug discovery. The presence of the sulfonyl group can enhance the bioactivity and metabolic stability of the compound, making it a candidate for therapeutic applications.
- Structure-Activity Relationship: Understanding the structural components of this molecule can lead to insights into its biological activity. The azepan ring contributes to the compound's conformational flexibility, which is essential for interacting with biological targets.
- Research Applications: The unique structure of this compound allows it to be a useful tool in synthesizing potential inhibitors for various enzymes and receptors. Researchers often modify similar compounds to enhance their effectiveness or reduce side effects.
- Derivatives and Variants: The versatility of the urea functional group in organic chemistry enables the creation of various derivatives, each with unique properties. This adaptability allows chemists to tailor compounds to achieve desired biological responses.
- Environmental Impact: Evaluating the environmental effects of synthetic compounds is crucial. Understanding the degradation pathways and bioaccumulation potential of such molecules aids in assessing their ecological safety.
In conclusion, 1-(azepan-1-yl)-3-(p-tolylsulfonyl)urea represents a vibrant area of study in chemical research, illustrating the bridge between structure and function in medicinal chemistry. The ongoing exploration of such compounds may pave the way for novel therapeutic strategies in treating various diseases.
Synonyms
tolazamide
1156-19-0
Tolinase
Norglycin
Tolanase
Tolazolamide
Diabewas
Tolazamida
Tolazamidum
1-(Hexahydro-1-azepinyl)-3-p-tolylsulfonylurea
N-(p-Toluenesulfonyl)-N'-hexamethyleniminourea
NSC-70762
1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea
NCI-C03327
U-17835
4-(p-Tolylsulfonyl)-1,1-hexamethylenesemicarbazide
CCRIS 591
U 17835
Tolazamidum [INN-Latin]
Benzenesulfonamide, N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methyl-
Tolazamida [INN-Spanish]
1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
EINECS 214-588-3
Urea, 1-(hexahydroazepin-1-yl)-3-p-tolylsulfonyl-
BRN 1323565
HSDB 3192
Urea, 1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)-
UNII-9LT1BRO48Q
9LT1BRO48Q
NSC 70762
CHEBI:9613
DTXSID3021358
N-(azepan-1-ylcarbamoyl)-4-methylbenzenesulfonamide
AI3-50826
Benzenesulfonamide, N-(((hexahydro-1H-azepin-1-yl)amino)carbonyl)-4-methyl-
NSC70762
N-(((Hexahydro-1H-azepin-1-yl)-amino)carbonyl)-4-methylbenzenesulfonamide
MLS000028534
DTXCID401358
N-[(azepan-1-ylamino)carbonyl]-4-methylbenzenesulfonamide
5-20-04-00062 (Beilstein Handbook Reference)
Benzenesulfonamide, N-(((hexahydro-1H-azepin-1-yl)-amino)carbonyl)-4-methyl-
Tolazamide [USAN:USP:INN:BAN:JAN]
1-(Hexahydro-1H-azepin-1-yl)-3-(p-toluenesulfonyl)urea
NCGC00016009-10
SMR000058290
CAS-1156-19-0
Tolazamidum (INN-Latin)
Tolazamida (INN-Spanish)
N-(((hexahydro-1H-azepin-1-yl)amino)carbonyl)-4-methylbenzenesulfonamide
TOLAZAMIDE (MART.)
TOLAZAMIDE [MART.]
TOLAZAMIDE (USP-RS)
TOLAZAMIDE [USP-RS]
1-(((((4-Methylphenyl)sulfonyl)amino)carbonyl)amino)azepane
1-(4-Methylphenylsulfonyl)-3-(hexahydro-1H-azepin-1-yl)urea
TOLAZAMIDE (USP MONOGRAPH)
TOLAZAMIDE [USP MONOGRAPH]
N-[[(Hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methylbenzenesulfonamide
Tolazamide (USAN:USP:INN:BAN:JAN)
Tolinase (TN)
TOLBUTAMIDE IMPURITY C (EP IMPURITY)
TOLBUTAMIDE IMPURITY C [EP IMPURITY]
SR-01000003105
1-[(Azepan-1-ylamino)carbonyl]-4-methylbenzenesulfonamide
Tolazamid
1-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]azepane
Ronase
N-{[(hexahydro-1H-azepin-1-yl)-amino]carbonyl}-4-methylbenzenesulfonamide
Prestwick_865
Tolazamide (Standard)
Spectrum_001269
TOLAZAMIDE [MI]
TOLAZAMIDE [INN]
TOLAZAMIDE [JAN]
Opera_ID_1740
Prestwick0_000554
Prestwick1_000554
Prestwick2_000554
Prestwick3_000554
Spectrum2_001449
Spectrum3_001473
Spectrum4_000240
Spectrum5_001204
Lopac-T-2408
TOLAZAMIDE [HSDB]
TOLAZAMIDE [USAN]
TOLAZAMIDE [VANDF]
CHEMBL817
T 2408
3-azepan-1-yl-1-(4-methylphenyl)sulfonyl-urea
NCIOpen2_008361
TOLAZAMIDE [WHO-DD]
CBiol_001918
Lopac0_001195
Oprea1_061180
SCHEMBL34417
BSPBio_000627
BSPBio_001505
BSPBio_003025
KBioGR_000225
KBioGR_000939
KBioSS_000225
KBioSS_001749
Tolazamide (JAN/USP/INN)
1-(azepan-1-yl)-3-(4-methylbenzenesulfonyl)urea
MLS001076161
DivK1c_000212
SPECTRUM1501201
SPBio_001317
SPBio_002548
BPBio1_000691
GTPL6847
NCI-CO3327
WLN: T7NTJ AMVMSWR D1
TOLAZAMIDE [ORANGE BOOK]
BCBcMAP01_000061
HMS500K14
HY-B0920R
KBio1_000212
KBio2_000225
KBio2_001749
KBio2_002793
KBio2_004317
KBio2_005361
KBio2_006885
KBio3_000449
KBio3_000450
KBio3_002525
A10BB05
NINDS_000212
Bio1_000204
Bio1_000693
Bio1_001182
Bio2_000225
Bio2_000705
HMS1361L07
HMS1569P09
HMS1791L07
HMS1921P19
HMS1989L07
HMS2089L10
HMS2092L09
HMS2096P09
HMS2232L21
HMS3259O18
HMS3263P11
HMS3369L04
HMS3402L07
HMS3713P09
Pharmakon1600-01501201
BCP23550
HY-B0920
Tox21_110281
Tox21_201507
Tox21_300416
Tox21_501195
CCG-39178
MFCD00083504
NSC758149
AKOS015913823
Tox21_110281_1
DB00839
FT61359
KS-1438
LP01195
NC00590
NSC-758149
SDCCGSBI-0051162.P004
Benzenesulfonamide, {N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methyl-}
IDI1_000212
IDI1_033975
NCGC00016009-01
NCGC00016009-02
NCGC00016009-03
NCGC00016009-04
NCGC00016009-05
NCGC00016009-06
NCGC00016009-07
NCGC00016009-08
NCGC00016009-09
NCGC00016009-11
NCGC00016009-12
NCGC00016009-13
NCGC00016009-14
NCGC00016009-15
NCGC00016009-16
NCGC00016009-17
NCGC00016009-19
NCGC00016009-24
NCGC00023701-03
NCGC00023701-04
NCGC00023701-05
NCGC00023701-06
NCGC00023701-07
NCGC00023701-08
NCGC00023701-09
NCGC00023701-10
NCGC00254501-01
NCGC00259058-01
NCGC00261880-01
DA-68249
1-(azepan-1-yl)-3-(p-tolylsulfonyl)urea
SBI-0051162.P003
AB00052247
EU-0101195
NS00007143
SW196991-3
C71499
D00379
AB00052247-15
AB00052247_16
AB00052247_17
A921617
1-(azepan-1-yl)-3-[(4-methylbenzene)sulfonyl]urea
Q7814101
SR-01000003105-2
SR-01000003105-4
SR-01000003105-5
SR-01000003105-8
BRD-K32164935-001-06-8
BRD-K32164935-001-17-5
BRD-K32164935-001-28-2
BRD-K32164935-001-29-0
BRD-K32164935-001-30-8
BRD-K32164935-001-31-6
F2173-1137
Z1575267190
1-[(([(4-Methylphenyl)sulfonyl]amino)carbonyl)amino]azepane #
Tolazamide, United States Pharmacopeia (USP) Reference Standard
Benzenesulfonamide, N-[[(hexahydro-1-azepinyl)amino]carbonyl]-4-methyl-
BENZENESULFONAMIDE, N,((HEXAHYDRO-1H-AZEPIN-1-YL)AMINO)CARBONYL)-4-METHYL-
214-588-3
N-[[(Hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methylbenzenesulfonamide;N-(p-Toluenesulfonyl)-N'-hexa-methyleniminourea;1-(4-Methyl phenylsulfonyl)-3-(hexahydro-1H-azepin-1-yl)urea;Norglycin;U 17835
Solubility of 1-(azepan-1-yl)-3-(p-tolylsulfonyl)urea (C15H22N2O3S)
The solubility of 1-(azepan-1-yl)-3-(p-tolylsulfonyl)urea is an intriguing aspect of this compound that can significantly affect its applications in various fields. Here are some key points to consider:
In essence, the solubility of 1-(azepan-1-yl)-3-(p-tolylsulfonyl)urea can be expected to be quite favorable in polar solvents, which opens up possibilities for its use in pharmaceutical and chemical applications where aqueous solubility is key. Understanding the solubility characteristics is crucial for optimizing its utility in formulations and reactions.