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Vancomycin

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Identification
Molecular formula
C66H75Cl2N9O24
CAS number
1404-90-6
IUPAC name
1-[7-(2-amino-2-oxo-ethyl)-10-(3-amino-3-oxo-propyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-sec-butyl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxo-ethyl)carbamoyl]-3-methyl-butyl]pyrrolidine-2-carboxamide
State
State

Vancomycin is solid at room temperature. It is usually supplied in a stable solid crystalline form that can be reconstituted into a solution for injection.

Melting point (Celsius)
216.00
Melting point (Kelvin)
489.15
Boiling point (Celsius)
770.00
Boiling point (Kelvin)
1 043.15
General information
Molecular weight
1449.26g/mol
Molar mass
1 449.2550g/mol
Density
1.3000g/cm3
Appearence

Vancomycin typically appears as a white to off-white crystalline powder. It is often provided in powder form for reconstitution into a solution for intravenous administration. The powder can be hygroscopic and should be handled with care to avoid moisture exposure.

Comment on solubility

Solubility of 1-[7-(2-amino-2-oxo-ethyl)-10-(3-amino-3-oxo-propyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-sec-butyl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxo-ethyl)carbamoyl]-3-methyl-butyl]pyrrolidine-2-carboxamide

The solubility of the compound named 1-[7-(2-amino-2-oxo-ethyl)-10-(3-amino-3-oxo-propyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-sec-butyl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxo-ethyl)carbamoyl]-3-methyl-butyl]pyrrolidine-2-carboxamide is influenced by its complex structure and the presence of multiple functional groups.

Given the various substituents present, we can deduce several factors regarding its solubility:

  • Hydrophilicity: The presence of amino and hydroxy groups may enhance the compound’s solubility in polar solvents, such as water, due to hydrogen bonding.
  • Hydrophobic regions: The sec-butyl group and multiple carbonyl functionalities may lead to hydrophobic interactions, potentially reducing solubility in highly polar environments.
  • pH dependence: The solubility may vary significantly with changes in pH, particularly due to the presence of both amino and carboxamide groups which can ionize.
  • Solvent interactions: Solubility in organic solvents, particularly those with similar polarities to the compound, could be favorable, while solubility in non-polar solvents is likely to be poor.

Overall, while the compound is expected to exhibit solubility in a range of polar solvents, the intricate balance of hydrophilic and hydrophobic characteristics leads to a complex solubility profile. As stated, "solubility is key to exploring the biological activity of such intricate molecules," making further studies essential for comprehensive understanding.

Interesting facts

Interesting Facts about 1-[7-(2-amino-2-oxo-ethyl)-10-(3-amino-3-oxo-propyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-sec-butyl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxo-ethyl)carbamoyl]-3-methyl-butyl]pyrrolidine-2-carboxamide

This compound, due to its complex structure, falls into the category of polyfunctional molecules that possess a remarkable potential in pharmaceutical applications. Here are some fascinating insights:

  • Structural Complexity: The compound contains multiple functional groups, which may enhance its reactivity and interaction with biological targets. The presence of amino and carbamoyl groups is often linked to increased solubility and bioactivity.
  • Potential Applications: Given its unique design, this compound could serve as a drug candidate for treating various diseases, particularly in the field of cancer therapy. The cyclic and polyfunctional architectures are enticing for developing targeted delivery systems.
  • Mechanisms of Action: Compounds with similar structures often engage in multiple mechanisms of action, such as enzyme inhibition, which could be beneficial in developing therapies aimed at specific targets within cancer cells.
  • Research Implications: Scientists are continuously exploring the properties of such intricate molecules, as they can lead to breakthroughs in understanding biochemical pathways and improving drug design methodologies.

The synthesis and study of this compound demonstrate the intersection of chemistry and pharmaceutical science, illustrating how complex organic molecules can pave the way for innovative therapies. Furthermore, the study of such compounds highlights the importance of multidisciplinary approaches in tackling intricate biochemical challenges.

Synonyms
113-78-0
SCHEMBL38443
SCHEMBL20456238
DTXSID00861739
D07228
1-{7-(2-Amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-(butan-2-yl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl}prolylleucylglycinamide