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Zidovudine

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Identification
Molecular formula
C10H13N5O4
CAS number
30516-87-1
IUPAC name
1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
State
State

Zidovudine is in a solid state at room temperature.

Melting point (Celsius)
123.00
Melting point (Kelvin)
396.15
Boiling point (Celsius)
596.10
Boiling point (Kelvin)
869.30
General information
Molecular weight
267.25g/mol
Molar mass
267.2450g/mol
Density
1.5849g/cm3
Appearence

Zidovudine appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione

This compound, with the formula C10H13N5O4, exhibits a variable solubility profile depending on the solvent used. Understanding its solubility is crucial for applications in pharmaceuticals and chemical synthesis.

Factors Influencing Solubility

Several factors can affect the solubility of this compound, including:

  • Polarity of Solvent: The presence of polar hydroxymethyl and carbonyl groups suggests that the compound may dissolve well in polar solvents such as water and methanol.
  • Temperature: Higher temperatures typically increase solubility for many organic compounds, allowing for better dissolution.
  • pH of Solution: The ionization of functional groups can affect solubility, where acidic or basic conditions may enhance dissolution.

Predicted Solubility

Based on its structural features, one might expect the following:

  • Soluble in water: Due to the presence of hydroxyl and amino groups.
  • Moderately soluble in organic solvents: This may include solvents like ethanol or DMSO due to its organic nature.
  • Limited solubility in non-polar solvents: Such as hexane and other aliphatic hydrocarbons.

In summary, the solubility of 1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione is influenced by the solvent's characteristics and environmental conditions, underlining the necessity for careful consideration during experimental application. Testing in various solvents is recommended to determine the optimal conditions for effective use.

Interesting facts

Interesting Facts about 1-[5-(Hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione

This intriguing compound is a member of the pyrimidine family, known for its diverse applications in medicinal chemistry. Pyrimidines are key building blocks in the synthesis of nucleotides, which comprise the structural backbone of DNA and RNA. Here are some noteworthy aspects of this specific compound:

  • Structural Diversity: The presence of a hydroxymethyl group and a tetrahydrofuran ring contributes to its structural complexity, potentially influencing its biological activity.
  • Pharmacological Potential: Compounds featuring pyrimidine derivatives often exhibit varied pharmacological properties, including antitumor, antiviral, and anti-inflammatory effects. Research into this compound might reveal novel therapeutic uses.
  • Synthetic Routes: The synthesis of this compound often involves advanced organic chemistry techniques, including cyclization reactions and functional group modifications. Such procedures showcase the innovative approaches chemists employ to create complex molecules.
  • Research Applications: Due to its unique structure, this compound is of interest in drug design studies. Scientists continue to explore how modifications to its framework can enhance selectivity and potency against specific biological targets.

In the words of Nobel Prize-winning chemist Ahmed Zewail, "Chemistry is not about molecules; it's about molecules interacting, changing, and creating." This compound exemplifies the dynamic nature of chemical research and its potential to impact various fields.

As we delve deeper into the study of 1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione, we uncover the endless possibilities that lie within complex chemical structures, paving the way for innovations in medicine and beyond.

Synonyms
1-(5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
892223-43-7
1-[5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
NSC617596
ChemDiv3_005698
MLS001195889
CHEMBL23970
SCHEMBL762579
DTXSID80863170
HMS1489C22
HMS2866A15
CCG-24684
AKOS015842611
NSC-617596
1-[5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
IDI1_023608
NCGC00096106-01
PD150967
SMR000558761
SY066870
3 inverted exclamation mark -Deoxythymidine
DB-225710
EU-0083580
SR-01000086413
SR-01000086413-1
1-[5-(Hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
1-(5-(hydroxymethyl)-tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione