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Nicotinamide adenine dinucleotide phosphate

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Identification
Molecular formula
C21H28N7O17P3
CAS number
53-59-8
IUPAC name
1-[5-[[[[5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-3,4-dihydroxy-tetrahydrofuran-2-yl]pyridin-1-ium-3-carboximidothioic acid
State
State

At room temperature, Nicotinamide adenine dinucleotide phosphate is typically in the form of a solid powder. It is generally stored in a dry and dark place to maintain its stability.

Melting point (Celsius)
110.00
Melting point (Kelvin)
383.15
Boiling point (Celsius)
133.00
Boiling point (Kelvin)
406.15
General information
Molecular weight
743.41g/mol
Molar mass
743.4050g/mol
Density
0.6000g/cm3
Appearence

Nicotinamide adenine dinucleotide phosphate (NADP+) appears as a white to off-white, crystalline powder. It is hygroscopic and sensitive to light and moisture.

Comment on solubility

Solubility of 1-[5-[[[[5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-3,4-dihydroxy-tetrahydrofuran-2-yl]pyridin-1-ium-3-carboximidothioic acid

The solubility characteristics of this intricate compound, C21H28N7O17P3, can be quite complex due to its multifunctional structure and various polar functional groups. Here are some key points to consider:

  • Hydrophilicity: The presence of multiple hydroxyl (–OH) groups and phosphonic acid moieties strongly suggests that this compound may exhibit significant solubility in polar solvents, most notably water.
  • Hydrophobic interactions: Despite its hydrophilic characteristics, certain regions of the molecule may introduce hydrophobicity, impacting overall solubility profiles.
  • pH Sensitivity: The compound may display variable solubility depending on pH, as several functional groups can ionize, enhancing solubility in certain pH ranges.
  • Complex Formation: This compound might also engage in complexation with cations or other molecular entities, which can impact its effective solubility in biological or chemical environments.

In conclusion, while hydrophilicity is expected due to the polar groups, the exact solubility can be influenced by numerous factors such as solvent type, temperature, and ionic strength, making extensive empirical testing important to ascertain precise solubility metrics.

Interesting facts

Interesting Facts about 1-[5-[[[[5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-3,4-dihydroxy-tetrahydrofuran-2-yl]pyridin-1-ium-3-carboximidothioic acid

This complex organic compound is a fascinating example of the intricacies of biochemical interactions and molecular design. Here are some engaging facts about this compound:

  • Nucleotide Analogue: This compound contains functional groups that closely relate to nucleic acids, and as such, it can mimic structure and function within biological systems.
  • Multi-Functional Properties: Its structure suggests it may have applications in drug design or as a therapeutic agent, particularly due to the presence of biological moieties such as purines and phosphoryl groups.
  • Potential in Gene Therapy: Compounds with similar structures are often investigated for their roles in gene therapy, where they may help deliver genetic material into cells more efficiently.
  • Phosphoryl Groups: The numerous phosphoryl groups in its structure are critical for energy transfer processes within cells and can have various roles in signaling pathways.
  • Inhibition Studies: The compound could serve as a potent inhibitor for certain enzymes involved in metabolism, particularly those connected with nucleotide synthesis.
  • Structural Complexity: The level of complexity in this compound highlights the incredible diversity of organic compounds, demonstrating that even small changes in structure can lead to significant differences in properties and functions.

As a scientist or a chemistry student, exploring the chemistry behind such complex molecules can lead to groundbreaking discoveries and innovations in the field of biochemistry and medicinal chemistry. In studying these compounds, we gain deeper insights into how molecular architecture influences biological activity.