Interesting facts
Interesting Facts about 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenyl-methyl]piperazine
This intriguing compound belongs to the piperazine family, which is well-known for its versatility in medicinal chemistry. Here are some significant aspects of this compound:
- Structure Highlights: The compound features a central piperazine ring, a characteristic of many pharmaceutical agents. The substituents, including a tert-butylphenyl and a chlorophenyl group, contribute to its diverse chemical behavior.
- Pharmaceutical Potential: Compounds similar to this one often demonstrate various biological activities, making them vital in the development of new therapeutic agents.
- Synthetic Pathways: The synthesis of this compound can engage various reaction mechanisms, including nucleophilic substitutions and coupling reactions, which showcases the creativity involved in organic synthesis.
- Research Applications: As a piperazine derivative, it is a template for exploring modifications that can enhance selective binding to specific receptors in biological systems.
- Real-World Relevance: Understanding such compounds can lead to advancements in treating a range of conditions including anxiety and depression, given the role of piperazine derivatives in neuropharmacology.
The study of compounds like 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenyl-methyl]piperazine not only contributes to our knowledge of organic chemistry but also highlights the intricate link between structure and activity in drug design. As scientists continue to explore this compound, they may uncover new therapeutic pathways and applications.
Synonyms
Buclizine
82-95-1
Histabuticine
Histabutizine
Histabutyzine
Buclifen
Aphilan-R base
Buclizina
Buclizinum
Vibazine
Buclizinum [INN-Latin]
Buclizina [INN-Spanish]
Buclizine [INN:BAN]
Buclizine (INN)
AH 2526
Aphilan R
Vibazine hydrochloride
1-(p-tert-Butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazine
EINECS 201-448-1
1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine
BRN 0349567
CHEBI:3205
Buclizine, (+)-
Buclizine, (-)-
Histabutyzine hydrochloride
Histabutyzine dihydrochloride
BUCLIZINE [INN]
BUCLIZINE [MI]
BUCLIZINE [VANDF]
component of Softran
0C94V6X681
BUCLIZINE [WHO-DD]
Buclizine, hydrochloride
component of Bucladin-S
UFN4445AF2
Hitabutyzyne
DTXSID0022694
1-(4-tert-Butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine
1178B2VD9B
4-23-00-00082 (Beilstein Handbook Reference)
1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)(phenyl)methyl]piperazine
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-
Posdel
Buclizinum (INN-Latin)
1-(p-tert-Butylbenzyl)-4-(p-chloro-.alpha.-phenylbenzyl)piperazine
NSC25141
Buclizina (INN-Spanish)
1-(4-Tert-butylbenzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine
PIPERAZINE, 1-(p-tert-BUTYLBENZYL)-4-(p-CHLORO-alpha-PHENYLBENZYL)-
Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)-
Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)-, (+)-
Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)-, (-)-
163837-51-2
163837-52-3
Buclina (TN)
UCB-4445
UNII-0C94V6X681
1-((4-tert-butylphenyl)methyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine
Bucladin (Salt/Mix)
Longifene (Salt/Mix)
1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenylmethyl]piperazine
UNII-UFN4445AF2
SCHEMBL27855
UCB-4445 (Salt/Mix)
UNII-1178B2VD9B
DTXCID702694
GTPL7134
CHEMBL1201271
R06AE01
1-(p-tert-Butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)piperazine
HY-A0128
MFCD00242701
1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenyl-methyl]piperazine
AKOS015962163
DB00354
1-[(4-chlorophenyl)(phenyl)methyl]-4-{[4-(1,1-dimethylethyl)phenyl]methyl}piperazine
Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)-(9CI)
NCGC00386387-01
NCGC00386387-02
NCGC00386387-03
AC-15954
BS-49162
DA-71800
NCI60_002006
CS-0017445
NS00008151
C07777
D07547
F15132
EN300-7414506
L000971
Q4859329
BRD-A91444184-300-01-9
1-(4-tert-Butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine #
Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-.alpha.-phenylbenzyl)-
1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)piperazine
201-448-1
Solubility of 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenyl-methyl]piperazine
The solubility of the compound 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenyl-methyl]piperazine can be influenced by various factors due to its complex structure. Typically, compounds containing bulky aromatic groups such as tert-butyl and chlorophenyl tend to display varied solubility characteristics. Here are some key points to consider:
In conclusion, while 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenyl-methyl]piperazine may have good solubility in various organic solvents, its solubility in water is expected to be quite limited. Therefore, it is essential to select appropriate solvents for practical applications and formulations involving this compound.