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4-Iodo-2,5-dimethoxyamphetamine (DOI)

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Identification
Molecular formula
C13H20INO2
CAS number
50745-43-2
IUPAC name
1-(4-iodophenyl)-N-isopropyl-propan-2-amine
State
State

State at Room Temperature: Solid

At room temperature, DOI is typically a solid due to its crystalline structure, which contributes to its stability at standard conditions.

Melting point (Celsius)
194.00
Melting point (Kelvin)
467.15
Boiling point (Celsius)
306.50
Boiling point (Kelvin)
579.70
General information
Molecular weight
307.21g/mol
Molar mass
307.2120g/mol
Density
1.5120g/cm3
Appearence

Appearance: 4-Iodo-2,5-dimethoxyamphetamine is typically found in crystalline powder form, appearing as white to off-white crystals. The compound may also be synthesized and used in solution form for research purposes.

Comment on solubility

Solubility of 1-(4-iodophenyl)-N-isopropyl-propan-2-amine (C13H20INO2)

The solubility of 1-(4-iodophenyl)-N-isopropyl-propan-2-amine is an intriguing aspect that merits attention. This compound, featuring both polar and non-polar characteristics, tends to exhibit varying solubility behaviors depending on the medium. Here are some key points regarding its solubility:

  • Polar solvents: Compounds containing iodine and other polar functional groups generally show a degree of solubility in polar solvents, although the bulky isopropyl group may hinder complete dissolution.
  • Non-polar solvents: The hydrophobic nature of the aromatic phenyl group combined with the isopropyl moiety suggests that 1-(4-iodophenyl)-N-isopropyl-propan-2-amine is likely to be more soluble in non-polar solvents like hexane or toluene.
  • Water solubility: Due to the limited polarity, the solubility in water is generally expected to be low; it may be categorized as insoluble or very slightly soluble.

In summary, the solubility pattern of 1-(4-iodophenyl)-N-isopropyl-propan-2-amine can be summarized as:

  1. More soluble: Non-polar organic solvents
  2. Moderately soluble: Polar organic solvents
  3. Less soluble: Water

Understanding the solubility characteristics is crucial for applications involving this compound, guiding formulation processes and predicting behavior in various environments.

Interesting facts

Interesting Facts about 1-(4-Iodophenyl)-N-isopropyl-propan-2-amine

1-(4-Iodophenyl)-N-isopropyl-propan-2-amine, often referred to as a compound of interest in medicinal chemistry, stands out due to several compelling features:

  • Pharmacological Potential: This compound is part of a class of molecules that may have implications in developing new therapeutic agents, potentially targeting different neurological conditions.
  • Structural Insights: The presence of an iodo substituent (4-iodophenyl) on the phenyl ring may contribute to its unique properties, affecting both its reactivity and biological activity.
  • Synthesis Challenges: The synthesis of this compound may involve intricate multi-step processes, often requiring advanced techniques in organic chemistry.
  • Research Relevance: Compounds with similar structures are frequently studied for their interactions with neurotransmitter systems, highlighting their relevance in neuropharmacology.
  • Analytical Techniques: Scientists utilize various analytical techniques, such as NMR and mass spectrometry, to elucidate the structural properties and confirm the successful synthesis of such compounds.

This compound serves as an excellent example of how small changes in molecular structure can lead to significant variations in biological activity. As noted by renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." Research into compounds like 1-(4-Iodophenyl)-N-isopropyl-propan-2-amine continues to fuel innovation and discovery in the ever-evolving field of medicinal chemistry.

Synonyms
iofetamine
Iodine-123-IMP
N-Isopropyl-p-iodoamphetamine
82691-33-6
(+/-)-N-Isopropyl-4-iodoamphetamine
95896-48-3
1-(4-iodophenyl)-N-propan-2-ylpropan-2-amine
C2A5X08042
UNII-C2A5X08042
Iofetamine I 123
Benzeneethanamine, 4-iodo-alpha-methyl-N-(1-methylethyl)-
DTXSID3048443
Benzeneethanamine, 4-iodo-alpha-methyl-N-(1-methylethyl)-, (+/-)-
IOFETAMINE I 123 [MI]
BENZENEETHANAMINE, 4-IODO-.ALPHA.-METHYL-N-(1-METHYLETHYL)-, (+/-)-
N Isopropyl p iodoamphetamine
Lopac0_000694
SCHEMBL1534301
CHEMBL1201308
DTXCID9028417
ISEHJSHTIVKELA-UHFFFAOYSA-N
VDA89648
Tox21 111239
CCG-204779
SDCCGSBI-0050672.P002
NCGC00015533-02
NCGC00015533-03
NCGC00162226-01
1-(4-Iodophenyl)-N-(1-methylethyl)propan-2-amine
(2R)-1-(4-iodophenyl)-N-propan-2-ylpropan-2-amine
Q15409426