4'-Hydroxyacetophenone | Solubility of Things

Identification

Molecular formula

C₈H₈O₂

CAS number

99-93-4

IUPAC name

1-(4-hydroxyphenyl)ethanone

State

At room temperature, 4'-Hydroxyacetophenone is typically found in a solid crystalline form.

Melting point (Celsius)

109.00

Melting point (Kelvin)

382.15

Boiling point (Celsius)

285.00

Boiling point (Kelvin)

558.15

General information

Molecular weight

136.15g/mol

Molar mass

136.1490g/mol

Density

1.2260g/cm³

Appearence

4'-Hydroxyacetophenone appears as a crystalline solid with an off-white to pale yellow color. It may sometimes be available as a fine powder depending on the purity and form of the sample.

Comment on solubility

Solubility of 1-(4-hydroxyphenyl)ethanone

The solubility of 1-(4-hydroxyphenyl)ethanone in various solvents can provide insight into its chemical behavior and applications. This compound, with its hydroxy and ketone functional groups, demonstrates interesting solubility characteristics:

Solvents: It is typically soluble in polar solvents such as ethanol and methanol due to the presence of the hydroxy group which can form hydrogen bonds.
Limited Solubility: In nonpolar solvents like hexane, 1-(4-hydroxyphenyl)ethanone exhibits low solubility. This is attributed to the hydrophilic nature of the hydroxyl group contrasted with the hydrophobic parts of the molecule.
Temperature Dependence: Solubility can be affected by temperature; generally, increasing temperature enhances solubility in most solvents.

In summary, the solubility of 1-(4-hydroxyphenyl)ethanone can be summarized as:

Soluble in polar solvents
Insoluble or poorly soluble in nonpolar solvents
Increased solubility with increased temperature

Understanding these solubility properties is crucial for utilizing 1-(4-hydroxyphenyl)ethanone in various chemical and industrial applications.

Interesting facts

Interesting Facts About 1-(4-hydroxyphenyl)ethanone

1-(4-hydroxyphenyl)ethanone, also known as 4'-hydroxyacetophenone, is an intriguing compound with various applications in the world of chemistry and industry. Here are some fascinating points about this compound:

Natural Occurrence: This compound can be found in some plants and has been identified as a part of their natural products, playing a potential role in their defense mechanisms.
Versatility: 1-(4-hydroxyphenyl)ethanone is widely used as a precursor in organic synthesis, particularly in the production of pharmaceuticals and fine chemicals.
Antioxidant Properties: The hydroxyl group (-OH) in its structure contributes to its ability to scavenge free radicals, making it of interest in the development of products that require antioxidative capabilities.
Architectural Backbone: This compound serves as a building block in the synthesis of various larger molecules, which are used in medicinal chemistry and materials science.
Colorimetric Applications: Due to its ability to form colored complexes, 1-(4-hydroxyphenyl)ethanone finds its use in analytical chemistry for determining metal ion concentrations.

In summary, the unique properties and an array of applications make 1-(4-hydroxyphenyl)ethanone a compound of interest not only for chemists but also for those working across multiple scientific disciplines. Its structural features and functional versatility pave the way for continued exploration and innovation.

Synonyms

4'-Hydroxyacetophenone

99-93-4

4-Hydroxyacetophenone

1-(4-Hydroxyphenyl)ethanone

P-HYDROXYACETOPHENONE

4-Acetylphenol

Piceol

Ethanone, 1-(4-hydroxyphenyl)-

p-Acetylphenol

p-Hydroxyphenyl methyl ketone

para-Hydroxyacetophenone

p-Oxyacetophenone

Methyl p-hydroxyphenyl ketone

4-hydroxy acetophenone

Acetophenone, 4'-hydroxy-

Phenol, p-acetyl-

Acetophenone, p-hydroxy-

1-(4-Hydroxyphenyl)Ethan-1-One

(4-Hydroxyphenyl)ethan-1-one

USAF KF-15

4-Hydroksyacetofenol

HYDROXYACETOPHENONE, PARA

4-Acetophenol

4'-hydroxy acetophenone

NSC 3698

Methyl-p-hydroxyphenyl ketone

MFCD00002359

4-Hydroksyacetofenol [Polish]

1-(4-Hydroxy-phenyl)-ethanone

HYDROXYACETOPHENONE

G1L3HT4CMH

EINECS 202-802-8

DTXSID0029133

CHEBI:28032

Paracetamol Impurity E

AI3-12133

NSC-3698

4-Hydroxyphenyl Methyl Ketone

CHEMBL201083

DTXCID209133

FEMA NO. 4330

EC 202-802-8

4-HYDROXYACETOPHENONE [FHFI]

c0694

PARACETAMOL IMPURITY E [EP IMPURITY]

AC6

1-(4-Hydroxyphenyl)ethanone (4-Hydroxyacetophenone)

CAS-99-93-4

PARACETAMOL IMPURITY E (EP IMPURITY)

UNII-G1L3HT4CMH

pAcetylphenol

pOxyacetophenone

4Acetylphenol

Phenol, pacetyl

4Hydroksyacetofenol

hydroxyacetophenones

pHydroxyacetophenone

1-(4-Hydroxyphenyl)ethanone; Paracetamol Imp. E (EP); 4-Hydroxyacetophenone; Paracetamol Impurity E

p-Hydroxacetophenone

4'hydroxyacetophenone

parahydroxyacetophenone

4'-hyroxyacetophenone

p-hydroxy acetophenone

p-hydroxy-acetophenone

rho-hydroxyacetophenone

Acetophenone, phydroxy

4?-Hydroxyacetophenone

4''-hydroxyacetophenone

Acetaminophen Impurity E

Acetophenone, 4'hydroxy

4\'-Hydroxypropiophenone

(4-hydroxyphenyl)ethanone

acetophenone, 4-hydroxy-

1(4Hydroxyphenyl)ethanone

Methylphydroxyphenyl ketone

bmse000593

bmse000670

bmse010030

Methyl phydroxyphenyl ketone

pHydroxyphenyl methyl ketone

WLN: QR DV1

4-HAP

SCHEMBL40866

Ethanone, 1(4hydroxyphenyl)

BIDD:ER0242

1-(4-hydroxyphenyl) ethanone

1-(4-hydroxyphenyl)-ethanone

4'-Hydroxyacetophenone, 99%

278564_ALDRICH

CHEBI:24668

HY-Y0073R

1-(4-hydroxyphenyl)-1-ethanone

4-Hydroxyacetophenone (Standard)

HYDROXYACETOPHENONE [INCI]

NSC3698

2o48

Acetophenone, 4'-hydroxy-(8CI)

CS-D1120

HY-Y0073

STR01114

Tox21_200228

Tox21_303602

BDBM50177409

LT0047

STK397448

ZINC00330136

AKOS000118915

AC-6123

FH24301

NCGC00248570-01

NCGC00248570-02

NCGC00257375-01

NCGC00257782-01

261172-42-3

DA-49721

SY009665

4'-Hydroxyacetophenone, analytical standard

DB-269493

H0193

NS00003966

EN300-17800

4 inverted exclamation mark -Hydroxyacetophenone

AB00443569-03

AB-131/40179700

Q7190613

Z57040434

F0001-2341

1-(4-Hydroxyphenyl)ethanone;4-Acetophenol;4-Acetylphenol

2,5-CYCLOHEXADIEN-1-ONE, 4-(1-HYDROXYETHYLIDENE)-

202-802-8

4'-Hydroxyacetophenone (Acetaminophen Impurity E), Pharmaceutical Secondary Standards; Certified Reference Material