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Zidovudine

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Identification
Molecular formula
C10H13N5O4
CAS number
30516-87-1
IUPAC name
1-[4-(hydroxymethyl)-3,6-dioxabicyclo[3.1.0]hexan-2-yl]pyrimidine-2,4-dione
State
State

At room temperature, Zidovudine is generally a solid, specifically a powder.

Melting point (Celsius)
124.00
Melting point (Kelvin)
397.15
Boiling point (Celsius)
359.15
Boiling point (Kelvin)
632.30
General information
Molecular weight
267.24g/mol
Molar mass
267.2410g/mol
Density
1.4300g/cm3
Appearence

Zidovudine generally appears as a white to off-white crystalline powder when isolated. It is often ground finely and it is almost odorless.

Comment on solubility

Solubility of 1-[4-(hydroxymethyl)-3,6-dioxabicyclo[3.1.0]hexan-2-yl]pyrimidine-2,4-dione

The solubility of the compound 1-[4-(hydroxymethyl)-3,6-dioxabicyclo[3.1.0]hexan-2-yl]pyrimidine-2,4-dione, with the chemical formula C10H13N5O4, can be influenced by several factors, reflecting its unique structure. Here are some key points to consider:

  • Polarity: The presence of hydroxymethyl groups typically increases polarity, suggesting that this compound may exhibit higher solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with solvents can enhance solubility. Compounds with -OH groups often participate in hydrogen bonding, making them more soluble in aqueous environments.
  • Functional Groups: The pyrimidine and dioxabicyclic structures may introduce steric hindrance or additional intermolecular interactions, impacting solubility differently in various solvents.
  • pH Dependency: The solubility might also vary with pH, particularly if the compound can exist in ionized forms at different pH levels.

Therefore, predicting the exact solubility of this compound requires a thorough understanding of its interactions with solvents and conditions. In general, "the more functional groups available for interaction, the greater the potential for solubility." For researchers, exploring experimental solubility data in organic and aqueous solvents will provide valuable insights into its behavior in practical applications.

Interesting facts

Interesting Facts About 1-[4-(hydroxymethyl)-3,6-dioxabicyclo[3.1.0]hexan-2-yl]pyrimidine-2,4-dione

This intriguing compound is known for its unique structural features and potential applications in pharmaceutical chemistry. Here are some captivating aspects to consider:

  • Structural Complexity: The compound contains a bicyclic structure, which is not commonly found in many organic molecules. This bicyclic system offers unique reactivity and interacts differently with biological systems.
  • Functional Groups: It features multiple functional groups, including a pyrimidine ring and hydroxymethyl groups, which can enhance its solubility and reactivity under specific conditions. Such versatility often leads to enhanced biological activity.
  • Potential Applications: Compounds like this are of interest due to their potential use in various therapeutic areas, including antiviral and anticancer properties. Studying its interactions with biological targets could uncover valuable medicinal applications.
  • Research Importance: The exploration of similar compounds is crucial in drug design. The interplay between the bicyclic structure and the pyrimidine moiety opens avenues for creating targeted drugs with specific functionalities.
  • Synthetic Pathways: The synthesis of this compound may involve intricate multi-step reactions, providing insights into advanced synthetic techniques in organic chemistry.

Moreover, as scientists delve deeper into the study of compounds like 1-[4-(hydroxymethyl)-3,6-dioxabicyclo[3.1.0]hexan-2-yl]pyrimidine-2,4-dione, they not only expand the repository of chemical knowledge but also pave the way for innovation in therapeutic solutions.

Synonyms
14042-38-7
1-[(2R,4R)-2-(hydroxymethyl)-3,6-dioxabicyclo[3.1.0]hexan-4-yl]pyrimidine-2,4-dione
1-[4-(hydroxymethyl)-3,6-dioxabicyclo[3.1.0]hexan-2-yl]pyrimidine-2,4-dione
NSC88790
SCHEMBL26372495
DTXSID20930815
NSC-88790
NSC123849
NSC-123849
1-(2,3-Anhydropentofuranosyl)-4-hydroxypyrimidin-2(1H)-one