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Thymidine

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Identification
Molecular formula
C10H14N2O5
CAS number
50-89-5
IUPAC name
1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
State
State

Under standard conditions (room temperature), thymidine is in a solid state. It is typically used in research and biochemical applications in its crystalline form.

Melting point (Celsius)
185.00
Melting point (Kelvin)
458.15
Boiling point (Celsius)
399.40
Boiling point (Kelvin)
672.55
General information
Molecular weight
242.23g/mol
Molar mass
242.2290g/mol
Density
1.5809g/cm3
Appearence

Thymidine appears as a white crystalline powder. It is an odorless compound that can appear in solid form under standard laboratory conditions.

Comment on solubility

Solubility of 1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione

The solubility of the compound 1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione (C10H14N2O5) can be attributed to its unique molecular structure and functional groups. Understanding its solubility characteristics is essential for applications in pharmaceuticals, biochemistry, and material science. Here are some key points regarding its solubility:

  • Polarity: The presence of hydroxyl groups (-OH) and the pyrimidine moiety suggests that this compound is relatively polar, which typically enhances solubility in polar solvents such as water.
  • Solvent Compatibility: It is likely to be more soluble in aqueous solutions compared to non-polar organic solvents. This is due to its capacity to form hydrogen bonds with water molecules.
  • Temperature Influence: Generally, increasing temperature may enhance solubility for many organic compounds, including this one, as higher temperatures can disrupt intermolecular forces.
  • pH Sensitivity: The solubility could also depend on the pH of the solution, particularly if any functional groups can protonate or deprotonate.

In conclusion, while specific solubility data for this compound may not be readily available, its structural features imply a level of solubility in polar solvents. The intricate interplay of functional groups and molecular interactions is essential to consider when assessing its behavior in various environments.

Interesting facts

Interesting Facts about 1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione

This intriguing compound is a member of the pyrimidine family, which plays a vital role in many biological processes. Pyrimidines are essential building blocks of nucleic acids, making them key players in genetics and molecular biology. Below are some engaging aspects of this compound:

  • Biological Significance: Compounds like this one can serve as precursors to nucleotides, the building blocks of DNA and RNA. This emphasizes the importance of studying such molecules for advancements in genetics and biochemistry.
  • Structure Complexity: The unique structural features, including a pyrimidine ring combined with a tetrahydrofuran moiety, showcase the fascinating diversity found in organic compounds. The presence of hydroxymethyl and hydroxy groups hints at potential reactivity and interaction in biological systems.
  • Potential Applications: Due to its structural characteristics, this compound could be valuable in pharmaceutical development. Compounds related to pyrimidines are often investigated for their antimicrobial, antitumor, and antiviral properties, suggesting a promising future for similar structures.
  • Research Opportunities: The complexity of this compound opens various avenues for research—such as synthetic pathways, reaction mechanisms, and its interactions within biological systems. Chemists and biologists alike can explore the implications of this compound in medicinal chemistry and material science.

In conclusion, 1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione presents a fascinating opportunity for investigation. Its unique structure and potential biological significance make it a compound worth deeper exploration.

Synonyms
L-Thymidine
1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
16053-52-4
1-(2-deoxypentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
NSC21548
5-Methyl-1-beta-L-ribofuranosyl-2,4(1H,3H)-pyrimidinedione
.beta.-D-Ribofuranoside, thymine-1 2-deoxy-
1-(2/'-deoxy-beta-threopentofuranosyl)thymine
(1-[2-Deoxy-beta-D-ribofuranosyl]-5-methyluracil)
SMR000279619
1-(2'-Deoxy-beta-threopentofuranosyl)thymine
Deoxythymidin
|A-L-Thymidine
[1',2',3',4',5'-13C5]thymidine
Thymidine;|A-Thymidine
1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
CHEMBL6497
SCHEMBL19895
MLS006011417
MLS006011930
DTXSID20936337
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-.alpha.-D-erythro-pentofuranosyl)-5-methyl-
CHEBI:188725
IQFYYKKMVGJFEH-UHFFFAOYSA-N
HMS1672M07
HMS3655I15
HMS3741O13
ALBB-021998
BCP11390
BCP22954
BBL001145
MFCD00066756
NSC526738
STK366766
AKOS000656383
AKOS016316039
PB32085
SB20806
NCGC00166148-01
DA-49261
DS-14352
NCI60_001800
SY005232
SY029169
EN300-73704
SBI-0053225.0001
BRD-A16497681-001-01-1
Thymine, 1-(2-deoxy-.alpha.-D-erythro-pentofuranosyl)-
Z1162463429
15230A97-46A3-403C-BBF9-1A77960B8DE2
1-(2-deoxypentofuranosyl)-4-hydroxy-5-methylpyrimidin-2(1H)-one
1-(2-Deoxypentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
2,3H)-Pyrimidinedione, 1-(2-deoxy-.beta.-D-ribofuranosyl)-5-methyl-
1-(2-Deoxy-|A-L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
2,3H)-Pyrimidinedione, 1-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-5-methyl-
2,4(1H,3H)-Pyrimidinedione,1-(2-deoxy-b-D-threo-pentofuranosyl)-5-methyl-
1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione