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Zidovudine

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Identification
Molecular formula
C10H13N5O4
CAS number
30516-87-1
IUPAC name
1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3,5-dimethyl-pyrimidine-2,4-dione
State
State

At room temperature, Zidovudine is in a solid state. It is typically prepared as a granular or crystalline powder.

Melting point (Celsius)
123.00
Melting point (Kelvin)
396.15
Boiling point (Celsius)
633.00
Boiling point (Kelvin)
906.15
General information
Molecular weight
267.24g/mol
Molar mass
267.2410g/mol
Density
1.6200g/cm3
Appearence

Zidovudine appears as a white to off-white crystalline powder. It is odorless and usually appears in solid form. The powder is soluble in water to some extent, which makes it usable for various pharmaceutical applications.

Comment on solubility

Solubility of 1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3,5-dimethyl-pyrimidine-2,4-dione

The solubility of the compound 1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3,5-dimethyl-pyrimidine-2,4-dione, with the chemical formula C10H13N5O4, is an intriguing topic due to its complex structure.

Key Factors Influencing Solubility

Several factors can influence the solubility of this compound:

  • Molecular Structure: The presence of polar functional groups, such as hydroxyl (-OH) and carbonyl (C=O), suggests a potential for good solubility in polar solvents.
  • Hydration Effects: The compound's ability to form hydrogen bonds can enhance its interaction with water, contributing to higher solubility in aqueous solutions.
  • pH Levels: As the compound contains nitrogen atoms, its solubility may vary with pH, which could affect ionization and thereby influence its aqueous solubility.

It is essential to also consider:

  • The potential solubility in organic solvents, which could differ from its solubility in water due to differences in polarity.
  • The possible crystallinity of the substance, which can affect how readily it dissolves.

In summary, while the presence of hydroxyl and carbonyl groups hints that 1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3,5-dimethyl-pyrimidine-2,4-dione may exhibit notable solubility characteristics, the actual solubility will depend heavily on environmental conditions and the choice of solvent.

Interesting facts

Interesting Facts about 1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3,5-dimethyl-pyrimidine-2,4-dione

This compound, often referred to for its complex structure, presents a fascinating intersection of organic chemistry and biochemistry. Here are some intriguing highlights:

  • Structural Complexity: The compound features a unique pyrimidine ring combined with a tetrahydrofuran moiety. This structural intricacy allows for a variety of chemical interactions and biological activities.
  • Biological Relevance: Compounds with similar structures have been studied for potential pharmaceutical applications, particularly in nucleic acid metabolism and in the development of new antimicrobial agents.
  • Hydroxyl Groups: With multiple hydroxyl groups in its structure, this compound likely displays increased polarity, which can influence its solubility and reactivity in biological systems.
  • Synthetic Pathways: The synthesis of such complex molecules typically involves multi-step reactions, showcasing the skills and creativity required in organic synthesis. Understanding these pathways is essential for any aspiring chemist.
  • Research Potential: Ongoing research into the derivatives of this compound could pave the way for breakthroughs in drug design and development, particularly targeting diseases where metabolism plays a crucial role.

As a student or chemist, recognizing the implications of such compounds in both synthetic and natural contexts can uncover new avenues for exploration in medicinal chemistry and materials science.

Synonyms
CBMicro_022212
Oprea1_866416
JCVDICFLPGDHAT-UHFFFAOYSA-N
CCG-9390
NSC750726
BIM-0022228.P001
SR-01000210782
SR-01000210782-1