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Flunarizine

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Identification
Molecular formula
C26H26F2N2O3
CAS number
52468-60-7
IUPAC name
1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-piperidine-4-carboxylic acid
State
State

At room temperature, Flunarizine is a solid.

Melting point (Celsius)
242.00
Melting point (Kelvin)
515.15
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.15
General information
Molecular weight
474.59g/mol
Molar mass
474.5860g/mol
Density
1.2110g/cm3
Appearence

Flunarizine appears as an off-white to white crystalline powder.

Comment on solubility

Solubility of 1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-piperidine-4-carboxylic acid

The solubility of the compound C26H26F2N2O3 can be influenced by a variety of factors due to its complex structure. Here are some key points to consider:

  • Polarity: The presence of functional groups such as the carboxylic acid and cyano can contribute to its polar characteristics, which may enhance solubility in polar solvents.
  • Solvent Interactions: This compound might show varying solubility profiles in different solvents:
    • Water: Its solubility in water could be limited due to hydrophobic components.
    • Organic Solvents: It may demonstrate better solubility in organic solvents like ethanol or dimethyl sulfoxide (DMSO).
  • Temperature Effects: Increased temperatures typically promote solubility. Thus, heating the solvent can improve the dissolution of this compound.
  • pH Sensitivity: The solubility of the carboxylic acid group may be affected by the pH of the solution, as deprotonation leads to increased solubility in more basic conditions.

In conclusion, while there is no definitive statement regarding the solubility of this compound without empirical data, its solubility is likely influenced by polarity, solvent interactions, temperature, and pH. Understanding these factors is crucial for applications in formulations and the pharmaceutical industry.

Interesting facts

Interesting Facts about 1-[4-Cyano-4-(4-Fluorophenyl)Cyclohexyl]-3-Methyl-4-Phenyl-Piperidine-4-Carboxylic Acid

This complex organic compound belongs to a class of molecules known as piperidine derivatives, which are known for their diverse applications in medicinal chemistry. One of the most notable characteristics of this compound is its intricate molecular structure, which allows it to interact in specific ways with biological systems. Here are some intriguing aspects:

  • Diverse Applications: Piperidine derivatives are prevalent in pharmaceuticals, often used in the development of neuroactive drugs due to their ability to cross the blood-brain barrier.
  • Functional Groups: This compound features multiple functional groups, including a cyano group and a carboxylic acid, which contribute to its chemical reactivity and potential as a building block for further synthesis.
  • Fluorinated Phenyl Ring: The presence of fluorine not only modifies the electronic properties of the compound but can also enhance metabolic stability, often leading to prolonged effects in therapeutic applications.
  • Potential Mechanisms: Research suggests that compounds similar to this may interact with neurotransmitter receptors, potentially influencing mood and cognition.
  • Synthesis Challenge: The synthesis of such a complex molecule typically involves multiple steps and careful control of conditions, making it a rewarding challenge for synthetic chemists.

In summary, 1-[4-Cyano-4-(4-Fluorophenyl)Cyclohexyl]-3-Methyl-4-Phenyl-Piperidine-4-Carboxylic Acid is not just a remarkable chemical compound, but it also represents the intersection of organic chemistry and pharmacology. As highlighted by a chemist's insight, "The beauty of organic compounds lies not only in their structure but in their transformative potential within living organisms."

Synonyms
Cabastine
Cabastina
1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylic acid
SCHEMBL728714
SCHEMBL728716
CHEMBL2218900
BDBM85844
CAS_54385
NSC_54385
DB-056367
L001260