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1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole

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Identification
Molecular formula
C19H18ClN3
CAS number
.
IUPAC name
1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole
State
State

At room temperature, this compound is typically observed as a solid, consistent with its relatively high melting point.

Melting point (Celsius)
185.00
Melting point (Kelvin)
458.00
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.00
General information
Molecular weight
350.83g/mol
Molar mass
350.8330g/mol
Density
1.2300g/cm3
Appearence

This compound appears as a white to off-white crystalline powder. Its visual appearance is consistent with many benzimidazole derivatives, which tend to form crystalline structures.

Comment on solubility

Solubility of 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole

The solubility of 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole, with the chemical formula C19H18ClN3, plays a crucial role in determining its application and behavior in various environments. Understanding its solubility can provide insights into its pharmacokinetics and overall performance.

Key Factors Influencing Solubility:

  • Polarity: The presence of the chlorophenyl and pyrrolidinyl groups suggests that this compound may exhibit a balance of hydrophilic and hydrophobic characteristics, affecting its solubility in different solvents.
  • Temperature: Solubility can increase with temperature; thus, examining the temperature-dependence is essential for predicting its behavior in practical use.
  • pH of Solution: The solubility of such compounds can also be influenced by the pH, particularly due to the ionizable functional groups that may become protonated or deprotonated.

General Observations:

Common observations indicate that:

  • This compound may have limited solubility in water, common with many organic compounds having large hydrophobic portions.
  • Its solubility is likely enhanced in organic solvents such as ethanol, DMSO, or DMF, making these solvents preferable for preparative and analytical applications.

In conclusion, the solubility of 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole depending on varying factors results in diverse behaviors across different mediums. Evaluating  this property thoroughly is essential for optimizing its usage in various chemical and pharmaceutical applications.

Interesting facts

Compound Overview: 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole

This intriguing compound, known for its potential biological activities, combines elements of both aromatic and aliphatic organic chemistry in a fascinating way. The structure consists of a benzimidazole core, which is known for its diverse applications, especially in pharmacology.

Key Features

  • Aromatic Component: The presence of a 4-chlorophenyl group enhances the electron-withdrawing nature of the molecule, contributing to its stability and reactivity.
  • Pyrrolidine Ring: This five-membered nitrogen-containing ring is significant in medicinal chemistry, often linked to the activity of psychoactive substances and pharmaceuticals.
  • Medicinal Potential: Compounds like this one are often studied for their properties in treating various conditions, including neurological disorders and as potential anti-cancer agents.
  • Synthesis and Modification: The synthetic pathways involving this compound can lead to a wide variety of derivatives, each with unique properties, expanding the scope of its application.

As noted by chemists, "The merging of different functional groups within a single compound often reveals new pharmacological profiles that can be exploited in drug development." This compound exemplifies such an approach, highlighting the intricate dance between structure and activity in organic chemistry.

Moreover, the exploration of its interactions with biological systems is a significant area of research, making it a compound of interest for future investigations in both the laboratory and clinical settings. The journey from synthesis to potential therapeutic use is one that embodies the very essence of chemical discovery.

Synonyms
Clemizole
442-52-4
Clemizol
Histacur
Histakool
1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole
Clemizolum
Lergopenin
1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole
Depocural
1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole
1-p-Chlorobenzyl-2-(1-pyrrolidinylmethyl)benzimidazole
NSC 46261
NSC-46261
AL-20 FREE BASE
CHEBI:52140
T97CB3796L
AL 20 [AS HYDROCHLORIDE]
1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-
Benzimidazole, 1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-
1H-Benzimidazole, 1-((4-chlorophenyl)methyl)-2-(1-pyrrolidinylmethyl)-
Clemizolo
1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole
C19H20ClN3
Clemizolo [DCIT]
Clemizole [INN:BAN]
NCGC00015243-02
Clemizol [INN-Spanish]
Clemizolum [INN-Latin]
CAS-1163-36-6
UNII-T97CB3796L
EINECS 207-133-5
MFCD00051434
Clemizole (free base)
CLEMIZOLE [INN]
Clemizole (free base)?
CLEMIZOLE [MI]
Prestwick0_000227
Prestwick1_000227
Prestwick2_000227
Prestwick3_000227
Lopac-C-5040
CLEMIZOLE [WHO-DD]
Lopac0_000284
Oprea1_226569
SCHEMBL29938
BSPBio_000273
SPBio_002194
BPBio1_000301
CHEMBL1407943
DTXSID0046939
BDBM85747
GTPL10285
AAA44252
BCP07894
NSC_2782
NSC46261
1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole
s6410
AKOS001631429
CCG-106577
CS-1481
SDCCGSBI-0050272.P003
NCGC00015243-01
NCGC00015243-03
NCGC00015243-04
NCGC00015243-05
NCGC00015243-06
NCGC00015243-07
NCGC00015243-11
NCGC00015243-20
NCGC00015243-21
NCGC00024376-03
AS-56130
CAS_442-52-4
DA-51956
HY-30234
SBI-0050272.P002
NS00005706
L000853
Q5131527
SR-01000000057-6
SR-01000000057-9
BRD-K04704168-003-03-6
BRD-K04704168-003-11-9
BRD-K04704168-003-14-3
F0902-3266
1-(4-CHLOROBENZYL)-2-PYRROLIDINOMETHYL-BENZIMIDAZOLE
Pyrrolidine, 1-[(1-p-chlorobenzyl-2-benzimidazolyl)methyl]-
1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole #
1-[(4-Chlorophenyl)methyl]-2-(pyrrolidinylmethyl)-1H-benzimidazole
GX0