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Cetirizine

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Identification
Molecular formula
C21H25ClN2
CAS number
83881-51-0
IUPAC name
1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-piperazine
State
State
Cetirizine is generally found in the form of a solid at room temperature.
Melting point (Celsius)
111.00
Melting point (Kelvin)
384.15
Boiling point (Celsius)
487.30
Boiling point (Kelvin)
760.45
General information
Molecular weight
388.89g/mol
Molar mass
388.8850g/mol
Density
1.0500g/cm3
Appearence

Cetirizine is typically found as white or slightly yellow crystalline powder.

Comment on solubility

Solubility of 1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-piperazine

The compound 1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-piperazine, with the chemical formula C21H25ClN2, exhibits interesting solubility characteristics that are essential for its practical applications. Understanding its solubility can be broken down into several key aspects:

  • Solvent Affinity: This compound is likely to be soluble in organic solvents due to its hydrophobic aromatic rings and the presence of a chlorine atom which can enhance its interaction with non-polar media.
  • Water Solubility: The solubility in water is expected to be low. The presence of large hydrophobic groups suggests a preference for organic solvents over aqueous solutions.
  • Concentration Dependence: As with many organic compounds, its solubility may vary significantly with concentration. A decrease in solubility may occur at higher concentrations, leading to precipitation.
  • Temperature Influence: Typically, increasing the temperature can enhance solubility for many organic compounds; therefore, elevated temperatures might improve the solubility of this piperazine derivative.

In summary, while the solubility profile of 1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-piperazine indicates that it is more suited for organic environments, it is crucial to perform specific solubility tests in various solvents to accurately determine its behaviour in practical scenarios. The insights gained from these tests will undoubtedly provide a deeper understanding of its potential uses in various chemical contexts.

Interesting facts

Interesting Facts about 1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-piperazine

1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-piperazine, often referred to as a specialized organic compound, belongs to the class of piperazine derivatives. Compounds like these play significant roles in medicinal chemistry due to their diverse biological activities. Here are some intriguing aspects of this compound:

  • Pharmacological Potential: Piperazines are often explored for their potential pharmaceutical applications, including as antidepressants, antipsychotics, and anti-anxiety medications.
  • Structural Significance: The presence of the 4-chlorophenyl and phenyl-methyl groups suggest that this compound may exhibit unique interactions within biological systems, resulting from its carefully designed structure.
  • CHLORO Group Influence: The chlorine atom in the chemical structure may enhance the compound's lipophilicity, potentially improving its ability to cross biological membranes.
  • Research Interest: Compounds of this nature are often targets for drug development and can serve as lead compounds in the synthesis of more complex molecules.

Scientists often quote the late chemist Paul Ehrlich, who stated, “Chemistry is a science of observation and experimentation, but the knowledge gained is only as good as our ability to utilize it.” This message holds true in the study of compounds like 1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-piperazine, where continued exploration can lead to groundbreaking therapeutic discoveries.

In summary, the study of piperazine derivatives such as this compound is essential in the quest for new medications and the understanding of the intricate interactions involved in drug design. Through collaborative research and innovation, the potential benefits of such compounds are indeed vast and promising.

Synonyms
chlorcyclizine
82-93-9
Chlorcycline
Alergicide
Perazyl
Trihistan
Chlorocycline
Chlorocyclizine
Histantine
Di-paralen
Diparalene
Histachlorazene
Compound 47-282
Clorciclizina
Piparalene
Chlorcyclizinum
Clorciclizinio
1-(4-Chlorobenzhydryl)-4-methylpiperazine
N-Methyl-N'-(4-chlorobenzhydryl)piperazine
NSC 25246
Chlorcyclizine free base
HSDB 3217
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine
EINECS 201-446-0
UNII-M26C4IP44P
NSC-25246
Chlorcyclizinum [INN-Latin]
Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-methyl-
Clorciclizinio [INN-Spanish]
BRN 0272719
M26C4IP44P
COMPD 47-282
1-(p-Chloro-alpha-phenylbenzyl)-4-methylpiperazine
1-((4-Chlorophenyl)phenylmethyl)-4-methylpiperazine
1-[(4-Chlorophenyl)phenylmethyl]-4-methylpiperazine
Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-methyl-
CHEMBL22150
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-methyl-
DTXSID9048011
NSC25246
82-93-9 (FREE BASE)
1-((4-chlorophenyl)(phenyl)methyl)-4-methylpiperazine
1-(p-Chloro-.alpha.-phenylbenzyl)-4-methylpiperazine
Chlorcyclizinum (INN-Latin)
Clorciclizinio (INN-Spanish)
chlorocyclizin
Clorciclizina [DCIT]
Piperazine, 1-(p-chloro-.alpha.-phenylbenzyl)-4-methyl-
Chlorcyclizine [INN:BAN]
1-[(4-Chlorophenyl)(phenyl)methyl]-4-methylpiperazine
Chlorcyclizin
Clorciclicina
Prestwick0_000706
Prestwick1_000706
Prestwick2_000706
Prestwick3_000706
CHLORCYCLIZINE [MI]
SCHEMBL4383
CHLORCYCLIZINE [INN]
Oprea1_854942
BSPBio_000891
CHLORCYCLIZINE [HSDB]
CHLORCYCLIZINE [VANDF]
DivK1c_000210
SPBio_002812
BPBio1_000981
CHLORCYCLIZINE [WHO-DD]
DTXCID5027988
CHEBI:94402
KBio1_000210
Piperazine, 1-(((4-chlorophenyl)phenyl)methyl)-4-methyl-
R06AE04
NINDS_000210
Chlorcyclizine, >=98% (HPLC)
BDBM50329371
MFCD00056036
PDSP1_000150
PDSP2_000149
AKOS015962157
DB08936
WLN: T6N DNTJ AYR&R DG& D1
IDI1_000210
NCGC00179384-01
NCGC00179384-10
AC-15952
TS-10037
SBI-0206679.P002
AB00053788
NS00000648
piperazine, 1-(4-chlorobenzhydryl)-4-methyl-
AB00053788_09
EN300-7478704
Q2393323
BRD-A57133233-003-03-7
BRD-A57133233-003-06-0
BRD-A57133233-003-11-0
1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-piperazine
1-[(4-Chloro-phenyl)-phenyl-methyl]-4-methyl-piperazine
PIPERAZINE, 1-((4-CHLOROPHENYL)PHENYLMETHYL)-4-METHYL)-
201-446-0