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Clonidine

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Identification
Molecular formula
C9H12ClN5
CAS number
4205-91-8
IUPAC name
1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-1,4-diazepane
State
State

Clonidine at room temperature is a solid.

Melting point (Celsius)
125.00
Melting point (Kelvin)
398.20
Boiling point (Celsius)
432.40
Boiling point (Kelvin)
705.60
General information
Molecular weight
252.77g/mol
Molar mass
226.6790g/mol
Density
1.2200g/cm3
Appearence

Clonidine is typically seen as a white crystalline powder.

Comment on solubility

Solubility of 1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-1,4-diazepane

The solubility of the compound 1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-1,4-diazepane (C9H12ClN5) is influenced by several factors related to its molecular structure and interactions with solvents. Understanding its solubility is crucial for assessing its potential applications in various chemical processes.

Factors Affecting Solubility:

  • Polarity: The presence of the polar chlorophenyl group may enhance the compound's ability to dissolve in polar solvents, but the overall nonpolar characteristics could limit solubility in water.
  • Molecular Weight: With a relatively high molecular weight, this compound may exhibit lower solubility compared to smaller, lighter molecules.
  • Hydrogen Bonding: The ability to form hydrogen bonds can also play a significant role in solubility, particularly in polar solvents like alcohols.
  • Temperature: Increasing temperature generally increases solubility; however, the specific impact can vary depending on the solvent used.

In summary, while 1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-1,4-diazepane may have some limited solubility in certain organic solvents, it is likely to be insoluble or poorly soluble in water due to its overall hydrophobic characteristics. Experimental data would be essential for providing precise solubility values in different solvents.

Interesting facts

Interesting Facts about 1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-1,4-diazepane

This compound is a fascinating member of the diazepane family, which is characterized by its unique five-membered ring structure containing two nitrogen atoms. Here are some noteworthy aspects:

  • Pharmacological Potential: Many compounds within the diazepane class are studied for their potential as therapeutic agents. This particular compound might also exhibit interesting biological activity, making it a candidate for further research in medicinal chemistry.
  • Chlorophenyl Group: The presence of the 4-chlorophenyl moiety not only contributes to the compound's overall structure but may also influence its electronic properties, potentially affecting its reactivity and interactions with biological targets.
  • Synthetic Route: The synthesis of 1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-1,4-diazepane could involve various methodologies, allowing for different synthetic strategies that might yield diverse derivatives, crucial for drug development.
  • Ring Flexibility: The diazepane ring imparts a certain degree of flexibility, which might affect how the compound interacts with protein targets, making it an interesting subject for conformational studies.
  • Research Applications: Investigating its potential uses in conditions like anxiety or as anti-depressants could open new avenues in therapeutic chemistry, as compounds that can interact with the central nervous system are of particular interest.

In summary, 1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-1,4-diazepane not only provides a compelling case study in structural chemistry but also offers avenues for pharmacological exploration. Future studies will undoubtedly help to unveil its full potential and enhance our understanding of diazepane derivatives.

Synonyms
Homochlorcyclizine
Curosajin
Homoclomine
Sankumin
Lysilan
Wicron
Homochlorocyclizine
Homodamon
848-53-3
Homorestar
Cromon S (base)
Homoginin (free base)
Homoclomin (free base)
Homochlogyl (free base)
Omoclorciclicina
(-)-Homochlorcyclizine
Homoclorociclizina
Homochlorcyclizinum
Omoclorciclicina [DCIT]
SA 97
Homochlorcyclizine [INN:BAN]
Homochlorcyclizinum [INN-Latin]
Homoclorciclizina
Homoclorociclizina [INN-Spanish]
1-[(4-chlorophenyl)-phenylmethyl]-4-methyl-1,4-diazepane
EINECS 212-699-1
N5MVC31W2N
NSC 25132
NSC-25132
N-(p-Chlorobenzhydryl)-N'-methylhomopiperazine
BRN 0279626
DTXSID9045635
(+)-Homochlorcyclizine
SA-97
Homochlorcyclizine (INN)
S8XST56UYL
Homochlorcyclizine, (+)-
Homochlorcyclizine, (-)-
6J3C5ABB9E
1H-1,4-Diazepine, 1-((4-chlorophenyl)phenylmethyl)hexahydro-4-methyl-
HOMOCHLORCYCLIZINE [MI]
HOMOCHLORCYCLIZINE [INN]
DTXCID7025635
(+/-)-HOMOCHLORCYCLIZINE
HOMOCHLORCYCLIZINE [WHO-DD]
5-23-03-00248 (Beilstein Handbook Reference)
142860-97-7
NCGC00018271-03
1-(p-Chloro-alpha-phenylbenzyl)hexahydro-4-methyl-1H-1,4-diazepine
1H-1,4-Diazepine, 1-(p-chloro-alpha-phenylbenzyl)hexahydro-4-methyl-
1H-1,4-DIAZEPINE, HEXAHYDRO-1-(p-CHLORO-alpha-PHENYLBENZYL)-4-METHYL-
Homochlorcyclizinum (INN-Latin)
Homoclorociclizina (INN-Spanish)
1-(P-CHLORO-.ALPHA.-PHENYLBENZYL)HEXAHYDRO-4-METHYL-1H-1,4-DIAZEPINE
1H-1,4-Diazepine, 1-[(4-chlorophenyl)phenylmethyl]hexahydro-4-methyl-
1-(4-CHLORODIPHENYLMETHYL)-4-METHYL-2,3,4,5,6,7-HEXAHYDRO-1,4-DIAZEPINE
1H-1,4-Diazepine, 1-((4-chlorophenyl)phenylmethyl)hexahydro-4-methyl-, (+)-
1H-1,4-Diazepine, 1-((4-chlorophenyl)phenylmethyl)hexahydro-4-methyl-, (-)-
142860-96-6
CAS-848-53-3
UNII-N5MVC31W2N
SR-01000000252
Prestwick0_000283
Prestwick1_000283
Prestwick2_000283
Prestwick3_000283
UNII-S8XST56UYL
1-((4-chlorophenyl)phenylmethyl)hexahydro-4-methyl-1H-1,4-diazepine
UNII-6J3C5ABB9E
SCHEMBL30402
BSPBio_000186
SPBio_002405
BPBio1_000206
CHEMBL1515447
BDBM77969
CHEBI:91588
cid_6602662
NSC25132
Tox21 110855
Tox21_110855
AKOS015962149
Tox21_110855_1
NCGC00018271-02
NCGC00018271-05
NCGC00018271-07
NCGC00089790-02
N-methyl-n'-p-chlorobenzhydryl homopiperazine
NS00038690
D08041
Q3882289
SR-01000000252-4
BRD-A22769835-300-03-2
BRD-A22769835-300-05-7
1H-1, 1-[(4-chlorophenyl)phenylmethyl]hexahydro-4-methyl-
1-[(4-Chlorophenyl)(phenyl)methyl]-4-methyl-1,4-diazepane
1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-1,4-diazepane
1H-1, 1-(p-chloro-.alpha.-phenylbenzyl)hexahydro-4-methyl-
1-[(4-chlorophenyl)-phenyl-methyl]-4-methyl-1,4-diazepane;hydrochloride
1-[(4-chlorophenyl)-phenylmethyl]-4-methyl-1,4-diazepane;hydrochloride
1H-1,4-Diazepine, 1-(p-chloro-alpha-phenylbenzyl)hexahydro-4-methyl-(8CI)
1H-1,4-Diazepine, 1-[(4-chlorophenyl)phenylmethyl]hexahydro-4-methyl-, dihydrochloride
212-699-1