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Bambuterol

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Identification
Molecular formula
C18H29Cl2N3O5
CAS number
81732-46-9
IUPAC name
1-(4-amino-3,5-dichloro-phenyl)-2-(tert-butylamino)ethanol
State
State

At room temperature, Bambuterol is found as a solid. This solid state makes it suitable for formulation into tablets for oral administration.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.15
Boiling point (Celsius)
310.80
Boiling point (Kelvin)
583.95
General information
Molecular weight
377.34g/mol
Molar mass
377.3370g/mol
Density
1.3400g/cm3
Appearence

Bambuterol typically appears as a white crystalline powder. It is tasteless and has no distinct odor. It is identifiable by its fine particulate nature and consistent powder-like texture.

Comment on solubility

Solubility of 1-(4-amino-3,5-dichloro-phenyl)-2-(tert-butylamino)ethanol

This compound, with the chemical formula C18H29Cl2N3O5, presents some intriguing characteristics in terms of solubility, which is influenced by its unique structure. Understanding the solubility can help in evaluating its behavior in various environments.

Solubility Insights:

  • Polarity: The presence of amine and hydroxyl functional groups typically indicates increased polarity, which can enhance solubility in aqueous environments.
  • Chlorine Atoms: The two chlorine substitutions might affect the compound's overall solubility profile, potentially reducing its solubility in some organic solvents compared to less halogenated analogs.
  • Hydrogen Bonding: The hydroxyl (-OH) group can engage in hydrogen bonding, further promoting solubility in polar solvents, particularly water.

In summary, the solubility of 1-(4-amino-3,5-dichloro-phenyl)-2-(tert-butylamino)ethanol is determined by a balance of its polar functional groups and the hydrophobic characteristics imparted by the tert-butyl group and chlorine atoms. As with many compounds, “like dissolves like” holds true, suggesting that this compound may be more soluble in polar solvents while exhibiting less solubility in nonpolar solvents. Further experimental determination would be necessary for precise solubility data.

Interesting facts

Interesting Facts about 1-(4-amino-3,5-dichloro-phenyl)-2-(tert-butylamino)ethanol

This compound, known for its intricate structure, is a fascinating subject of study in the field of chemistry due to its diverse applications and potential benefits. Here are some points to ponder:

  • Pharmaceutical Relevance: This compound has gained attention in medicinal chemistry, particularly for its potential role as a therapeutic agent. Compounds with similar structures are often explored for their efficacy in treating conditions such as hypertension and various neurological disorders.
  • Dichlorophenyl Moiety: The presence of the 3,5-dichloro substitution on the phenyl ring not only contributes to the compound's chemical properties but also enhances its biological activity, making it a key feature in drug design.
  • Tertiary Amino Group: The tert-butylamino group introduces steric hindrance, which can influence how the compound interacts with biological targets. This design choice is often utilized to improve selectivity and reduce side effects in pharmacological applications.
  • Research Potential: As scientists continuously search for novel compounds, this molecule represents a fruitful area of research, particularly in the development of new drugs. The balance of its amino groups and halogen substitutions suggests possible activities that warrant further investigation.

In summary, 1-(4-amino-3,5-dichloro-phenyl)-2-(tert-butylamino)ethanol is more than just a chemical structure; it embodies the intersection of chemistry, biology, and pharmacology, illustrating the intricate dance of atoms and the potential for life-changing applications. "Chemistry is not only about actions and reactions but also about possibilities and innovations."

Synonyms
clenbuterol
Planipart
37148-27-9
Clenbuterolum
Contraspasmin
dl-Clenbuterol
Clenbuterolum [INN-Latin]
NAB 365
Monores
(RS)-Clenbutero
(+-)-clenbuterol
(+/-)-clenbuterol
UNII-XTZ6AXU7KN
XTZ6AXU7KN
EINECS 253-366-0
4-Amino-3,5-dichloro-alpha-(((1,1-dimethylethyl)amino)methyl)benzenemethanol
Clenbuterol (INN)
1-(4-Amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol
BRN 1076467
DTXSID7022833
CHEBI:174690
EINECS 256-529-4
P 5369
NSC-758633
4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol
BENZENEMETHANOL, 4-AMINO-3,5-DICHLORO-alpha-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-
DTXCID902833
1-(4-Amino-3,5-dichloro-phenyl)-2-tert-butylamino-ethanol
Benzyl alcohol, 4-amino-alpha-((tert-butylamino)methyl)-3,5-dichloro-
NSC 758633
NCGC00163150-01
1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethan-1-ol
CLENBUTEROL [INN]
Clenbuterolum (INN-Latin)
1-(4-amino-3,5-dichlorophenyl)-2-[(1,1-dimethylethyl)amino]ethanol
4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcoho
4-Amino-alpha-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol
Contraspasmin (TN)
CAS-37148-27-9
Clenbuterol [INN:BAN]
clenbuterolo
Planipart [veterinary] (TN)
4-Amino-.alpha.-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol
Planipart (veterinary)
Spectrum_001564
Clenbuterol -Discontinued
CLENBUTEROL [MI]
Prestwick0_000345
Prestwick1_000345
Prestwick2_000345
Prestwick3_000345
Spectrum3_000975
Spectrum4_000743
Spectrum4_001099
Spectrum5_001497
SCHEMBL4722
BSPBio_000409
BSPBio_002609
CLENBUTEROL [WHO-DD]
KBioGR_001066
KBioGR_001518
KBioSS_002044
CHEMBL49080
DivK1c_000794
SPBio_002330
BPBio1_000451
BDBM27958
GTPL12582
KBio1_000794
KBio2_002044
KBio2_004612
KBio2_007180
KBio3_001829
See: C569998
R03AC14
R03CC13
NINDS_000794
HMS2089I15
ACA30603
Tox21_112016
AKOS007930151
Tox21_112016_1
DB01407
Benzenemethanol, 4-amino-3,5-dichloro-.alpha.-[[(1,1-dimethylethyl)amino]methyl]-
IDI1_000794
NCGC00163150-02
NCGC00163150-03
NCGC00163150-04
NCGC00163150-05
NCGC00163150-07
AC-10284
SBI-0051858.P002
AB00053680
NS00009664
D07713
AB00053680-12
AB00053680_13
(+/-)-Clenbuterol 100 microg/mL in Acetonitrile
EN300-25300193
Q223412
SR-01000721909-2
BRD-A75726477-003-04-9
BRD-A75726477-003-21-3
1-(4-Amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol #
4-Amino-3,5-dichloro-.alpha.-(((1,1-dimethylethyl)amino)methyl)benzenemethanol
Benzenemethanol,4-amino-3,5-dichloro-a-[[(1,1-dimethylethyl)amino]methyl]-,(as)-
253-366-0