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Salbutamol

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Identification
Molecular formula
C13H21ClF3N5O3
CAS number
18559-94-9
IUPAC name
1-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol
State
State

At room temperature, Salbutamol exists as a solid, typically handled in powdered form. This compound is stable under standard conditions, making it suitable for pharmaceutical formulations.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.00
Boiling point (Celsius)
187.00
Boiling point (Kelvin)
460.00
General information
Molecular weight
239.66g/mol
Molar mass
239.6590g/mol
Density
0.8570g/cm3
Appearence

Salbutamol typically appears as a white to off-white powder. It is known for its crystalline form when purified, which aids in its identification and usage in medical applications.

Comment on solubility

Solubility of 1-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol

The solubility of the compound 1-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol (C13H21ClF3N5O3) can be quite intriguing due to its complex structure. Understanding its solubility can provide insights into its potential applications and interactions. Here are some key points to consider:

  • Polarity: The presence of a chlorinated aromatic ring and trifluoromethyl group adds notable polarity to the compound. This suggests a tendency toward solubility in polar solvents.
  • Hydrogen Bonding: The hydroxyl (-OH) group in the molecule can form hydrogen bonds with solvents, enhancing its solubility in polar solvents such as water and alcohols.
  • Long Chain Structure: The tert-butyl group may impart some hydrophobic character, which could limit solubility in highly polar solvents but may be more soluble in organic solvents.
  • Practical Observations: While exact solubility data may vary, one can observe that compounds with similar functional groups often exhibit diverse solubility profiles based on environmental conditions such as temperature and pH.

In summary, the solubility of this compound is likely to be influenced by a balance of polar and non-polar interactions, making it versatile in different solvent environments. As chemists often say, the solubility makes the world go 'round! Exploring its solubility can lead to exciting discoveries in both laboratory settings and practical applications.

Interesting facts

Interesting Facts about 1-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol

This compound, a fascinating chemical entity, holds significance in various fields, including pharmaceuticals and materials science. Its unique structure combines aromatic and aliphatic components, resulting in intriguing properties and applications.

Key Characteristics

  • Functional Diversity: This compound features both amino and hydroxyl groups, making it suitable for various chemical reactions and modifications.
  • Fluorine Influence: The presence of trifluoromethyl groups is known to enhance the bioactivity and metabolic stability of molecules, making it an attractive target in drug design.
  • Chlorine Substitution: The chlorine atom not only aids in chemical reactivity but also influences the solubility and lipophilicity of the compound, which are crucial for biological interactions.

Potential Applications

This compound can be explored for:

  • Pharmaceutical Development: Its structural features may contribute to the development of new therapeutic agents for treating various diseases.
  • Biological Research: Researchers can utilize this molecule to study mechanisms of action and drug-target interactions due to its complex design.
  • Material Science: The chemical's unique properties may be leveraged in creating innovative materials with specific functionalities, such as improved conductivity or stability.

Quotable Insight

A senior chemist once stated, "Understanding the subtleties of compound structures like this one can unlock doors to revolutionary applications!" This emphasizes the importance of detailed compound study in driving advancements in science and technology.

In conclusion, 1-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol presents a remarkable representation of how intricate chemical architecture can lead to broad implications in scientific research and practical applications.

Synonyms
Mabuterol
56341-08-3
Mabuterol [INN]
AMBUTEROL
Mabuterolum
PB 868Cl
Mabuterolum [INN-Latin]
1-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol
CCRIS 5288
UNII-R4K19W6S7Q
Mabuterol free base
1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)-2-(tert-butylamino)ethanol
R4K19W6S7Q
4-Amino-alpha-((tert-butylamino)methyl)-3-chloro-5-(trifluoromethyl)benzyl alcohol
MABUTEROL [MI]
MABUTEROL [MART.]
MABUTEROL [WHO-DD]
56707-24-5
DTXSID3048283
56341-08-3 (free base)
Mabuterolum (INN-Latin)
MABUTEROL (MART.)
Benzenemethanol, 4-amino-3-chloro-alpha-(((1,1-dimethylethyl)amino)methyl)-5-(trifluoromethyl)-
4-AMINO-.ALPHA.-((TERT-BUTYLAMINO)METHYL)-3-CHLORO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL
4-Amino-3-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)benzenemethanol
Benzenemethanol, 4-amino-3-chloro-.alpha.-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-
NCGC00181010-01
Benzenemethanol, 4-amino-3-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-; 4-Amino-3-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)benzenemethanol; (+/-)-Mabuterol; Ambuterol; PB 868Cl
SCHEMBL82440
CHEMBL86749
DTXCID4028258
CHEBI:135325
WZB81958
AKOS016010365
1ST1321
FA24968
HY-13338
Mabuterol 1000 microg/mL in Acetonitrile
DB-014845
DB-291262
CS-0003199
NS00000016
L013373
Q6721687
BRD-A13116749-003-01-6
1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl ]-2-(tert-butylamino)ethanol
Amino-3-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)benzenemethanol;4-Amino-a-[(tert-butylamino)methyl]-5-(triflu oromethyl)benzene-methanol;Ambuterol;Mabuterol