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Tamoxifen

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Identification
Molecular formula
C26H29NO2
CAS number
10540-29-1
IUPAC name
1-[4-[2-(diethylamino)ethoxy]phenyl]-2-(4-methoxyphenyl)-1-phenyl-ethanol
State
State

At room temperature, tamoxifen is a solid.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
563.41
Boiling point (Kelvin)
836.56
General information
Molecular weight
371.52g/mol
Molar mass
563.4090g/mol
Density
1.0664g/cm3
Appearence

Tamoxifen typically appears as a white crystalline powder.

Comment on solubility

Solubility of 1-[4-[2-(diethylamino)ethoxy]phenyl]-2-(4-methoxyphenyl)-1-phenyl-ethanol (C26H29NO2)

The solubility of the compound 1-[4-[2-(diethylamino)ethoxy]phenyl]-2-(4-methoxyphenyl)-1-phenyl-ethanol is influenced by various factors due to its complex structure. Here are some key points to consider:

  • Polar vs. Nonpolar Nature: Given the presence of both hydrophilic (e.g., the ethanol group and diethylamino group) and hydrophobic (e.g., methoxy and phenyl groups) components in its structure, this compound may exhibit moderate solubility in polar solvents such as ethanol or methanol.
  • Solvent Interaction: Solubility can significantly vary depending on the solvent used. For polar solvents, solubility is often enhanced due to the formation of hydrogen bonds, particularly between the hydroxyl group and water molecules.
  • Temperature Effects: As with many organic compounds, increasing temperature can improve solubility, facilitating greater interaction with solvent molecules.
  • pH Sensitivity: The compound's solubility may also be affected by the pH of the solution, especially if the compound can ionize under certain conditions.

In summary, the solubility of C26H29NO2 is not a straightforward matter and is greatly influenced by the solvent choice, temperature, and pH. Understanding these factors is crucial for effectively utilizing this compound in various applications.

Interesting facts

Interesting Facts about 1-[4-[2-(diethylamino)ethoxy]phenyl]-2-(4-methoxyphenyl)-1-phenyl-ethanol

This compound is an intriguing example of a synthetic molecule, falling under the category of pharmaceuticals that have drawn significant scientific interest. Below are some key points that highlight its unique properties and applications:

  • Complex Structure: The molecular design features multiple aromatic rings and functional groups, making it a versatile compound in medicinal chemistry.
  • Pharmacological Potential: Compounds with similar structures are often investigated for their potential in treating various conditions, including neurological disorders and cancer therapies. The diethylamino group, in particular, may enhance its pharmacokinetic properties.
  • Design Strategy: The incorporation of the diethylamino group is a deliberate choice. It can increase solubility and improve receptor binding, which is crucial in drug design.
  • Research Opportunities: The cut between different fragment functionalities opens doors to research in fields like drug discovery and development of targeted therapies.

The synthetic route to producing such compounds is nuanced, emphasizing the importance of reaction conditions and reagents. As chemists, we often explore various synthetic methodologies to optimize yield and purity during synthesis.

Furthermore, this compound exemplifies a trend in the industry: the use of structure-activity relationship (SAR) studies to refine compounds for maximum efficacy. As a result, studying molecules like this not only advances our understanding of chemical behavior but also shapes the future of pharmaceutical innovation.

In summary, 1-[4-[2-(diethylamino)ethoxy]phenyl]-2-(4-methoxyphenyl)-1-phenyl-ethanol serves as a reminder of the intricate tapestry of chemical synthesis and its potential to impact human health. The exploration of such compounds continues to inspire scientists and students alike in the quest for new therapeutic agents.

Synonyms
ETHAMOXYTRIPHETOL
Ethanoxytriphetol
67-98-1
MER 25
MER-25
NSC 19857
(p-2-Diethylaminoethoxyphenyl)-1-phenyl-2-p-anisylethanol
BRN 2017765
UNII-2ND166F554
AI3-50793
NSC19857
NSC-19857
2ND166F554
1-(p-2-Diethylaminoethoxyphenyl)-1-phenyl-2-p-anisylethanol
DTXSID6020806
CHEBI:34748
1-(4-(2-Diethylaminoethoxy)phenyl)-1-phenyl-2-(p-anisyl)ethanol
1-[4-(2-Diethylaminoethoxy)phenyl]-1-phenyl-2-(p-anisyl)ethanol
1-(p-(2-(Diethylamino)ethoxy)phenyl)-1-phenyl-2-(p-methoxyphenyl)ethanol
NSC 19857;MER 25
Benzeneethanol, alpha-(4-(2-(diethylamino)ethoxy)phenyl)-4-methoxy-alpha-phenyl-
Ethanol, 1-(p-(2-(diethylamino)ethoxy)phenyl)-2-(p-methoxyphenyl)-1-phenyl-
1-[4-[2-(diethylamino)ethoxy]phenyl]-2-(4-methoxyphenyl)-1-phenylethanol
4-Methoxy-alpha-[4-[2-(diethylamino)ethoxy]phenyl]-alpha-phenylbenzeneethanol
1-(P-(2-DIETHYLAMINOETHOXY)PHENYL)-2-(P-METHOXYPHENYL)-1-PHENYLETHANOL
BENZENEETHANOL, .ALPHA.-(4-(2-(DIETHYLAMINO)ETHOXY)PHENYL)-4-METHOXY-.ALPHA.-PHENYL-
1-(4-(2-(Diethylamino)ethoxy)phenyl)-2-(4-methoxyphenyl)-1-phenylethanol
1-[p-[2-(Diethylamino)ethoxy]phenyl]-1-phenyl-2-(p-methoxyphenyl)ethanol
4-Methoxy-alpha-(4-(2-(diethylamino)ethoxy)phenyl)-alpha-phenylbenzeneethanol
Benzeneethanol, .alpha.-[4-[2-(diethylamino)ethoxy]phenyl]-4-methoxy-.alpha.-phenyl-
Ethanol, 1-[p-[2-(diethylamino)ethoxy]phenyl]-2-(p-methoxyphenyl)-1-phenyl-
CHEMBL47647
DTXCID60806
SCHEMBL330094
AKOS030584230
WLN: 2N2&2OR DXQR&1R DO1
1-(4-{[2-(diethylamino)ethyl]oxy}phenyl)-2-[4-(methyloxy)phenyl]-1-phenylethanol
DA-61574
NCI60_001651
PD011679
HY-118633
CS-0067656
Q25091482
{1-[4-(2-Diethylaminoethoxy)phenyl]-1-phenyl-2-(p-anisyl)ethanol}
1-[4-(2-diethylaminoethyloxy)phenyl]-2-(4-methoxyphenyl)-1-phenyl-ethanol
1-{4-[2-(diethylamino)-ethoxy]phenyl}-2-(4-methoxyphenyl)-1-phenylethanol
{1-[p-[2-(Diethylamino)ethoxy]phenyl]-1-phenyl-2-(p-methoxyphenyl)e} thanol
alpha-[4-[2-(Diethylamino)ethoxy]phenyl]-4-methoxy-alpha-phenylbenzeneethanol
Benzeneethanol, {.alpha.-[4-[2-(diethylamino)ethoxy]phenyl]-4-methoxy-.alpha.-pheny} l-
Ethanol, {1-[p-[2-(diethylamino)ethoxy]phenyl]-2-(p-methoxyphenyl)-1-phenyl-}