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Propranolol

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Identification
Molecular formula
C16H21NO2
CAS number
525-66-6
IUPAC name
1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)propan-2-ol
State
State

At room temperature, propranolol is in solid state.

Melting point (Celsius)
96.00
Melting point (Kelvin)
369.15
Boiling point (Celsius)
117.00
Boiling point (Kelvin)
390.15
General information
Molecular weight
295.40g/mol
Molar mass
295.3970g/mol
Density
1.1228g/cm3
Appearence

Propranolol is a white to off-white crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility of 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)propan-2-ol

The solubility of the compound 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)propan-2-ol (C16H21NO2) can be characterized by several important factors:

  • Polarity: This compound exhibits a moderate level of polarity due to the presence of various functional groups, which may influence its ability to dissolve in different solvents.
  • Solvent Compatibility: Generally, compounds with similar polarities tend to be more soluble in one another. As a result:
    • It may be more soluble in polar solvents such as water or alcohol.
    • It could have limited solubility in non-polar solvents like hexane or toluene.
  • Temperature Dependence: The solubility of this compound may also change with temperature. Higher temperatures often increase solubility for many organic compounds, allowing for:
    • Greater molecular motion.
    • Enhanced interactions with solvent molecules.
  • Crystal Structure: The crystalline nature of the compound can further influence solubility.

In summary, the solubility of this compound is influenced by a combination of its molecular structure, polarity, solvent interactions, temperature, and crystal formation. Understanding these factors is essential for applications in pharmaceutical formulations and chemical processes.

Interesting facts

Interesting Facts about 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)propan-2-ol

This compound belongs to a fascinating class of chemicals known as beta-blockers, which are widely researched for their ability to manage hypertension and various cardiovascular conditions. Below are some interesting aspects of this compound:

  • Structure: The unique combination of a phenoxy and isopropylamino group lends the compound a specific mode of action that can affect heart rate and vascular resistance.
  • Cyclopropyl group: The presence of the cyclopropylmethoxy group adds strain to the molecular structure, which can enhance the pharmacological activity by influencing receptor binding.
  • Mechanism of Action: Like other beta-blockers, it works by blocking beta-adrenergic receptors, leading to reduced heart rate and workload on the heart. This action is crucial in treating conditions such as anxiety and tachycardia.
  • Potential therapeutic applications: Besides hypertension, this compound might be investigated for its benefits in treating migraine, anxiety, and even in improving performance in certain athletic endeavors due to its calming effect on the heart.
  • Innovative research: Scientists are continually exploring new derivatives and analogs of such compounds that might lead to improved efficacy and reduced side effects.

As you delve deeper into the world of organic and medicinal chemistry, consider how the intricacies of each compound's structure can lead to profound impacts on health and wellness. The journey of discovery in each molecule tells a story of innovation and potential.

Synonyms
betaxolol
63659-18-7
Betaxololum
Betoptic
Kerlone
Betaxololum [INN-Latin]
Betaxolol S
UNII-O0ZR1R6RZ2
O0ZR1R6RZ2
Betaxolol (INN)
1-(4-(2-(Cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol
CHEBI:3082
DTXSID2022674
ALO-140102 FREE BASE
SL-7521210 FREE BASE
SL 75212
1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol
2-Propanol, 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-
DTXCID102674
KERLEDEX
NCGC00015159-06
BETAXOLOL [INN]
Betaxololum (INN-Latin)
1-(isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanol
Betaxolol [INN:BAN]
SL-75212-10
Dextrobetaxolol
1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)propan-2-ol
1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol
Betaxolol (TN)
CAS-63659-18-7
(R)-Betaxolol; (+)-Betaxolol
betaxololo
1-(isopropylamino)-3-(p-(cyclopropylmethoxyethyl)phenoxy)-2-propanol
1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-(propan-2-ylamino)propan-2-ol
2-Propanol, 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-
(+/-)-Betaxolol; 1-Isopropylamino-3-[4-(2-cyclopropylmethoxy-ethyl)phenoxy]-2-propanol; Betaxolol; Betoptic S; 2-Propanol, 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-
Betaxolol (Betoptic)
Betaxolol (Standard)
BETAXOLOL [MI]
Prestwick0_000382
Prestwick1_000382
Prestwick2_000382
Prestwick3_000382
BETAXOLOL [VANDF]
CHEMBL423
BETAXOLOL [WHO-DD]
Lopac0_000193
SCHEMBL23530
BSPBio_000563
GTPL549
108008-51-1
SPBio_002484
BPBio1_000621
HY-B0381R
C07AB05
S01ED02
HMS2089I07
HMS3655P17
HMS3884L05
HY-B0381
Tox21_110091
BDBM50405521
s2091
(R)-1-[4-(2-Cyclopropylmethoxy-ethyl)-phenoxy]-3-isopropylamino-propan-2-ol
AKOS015841671
Tox21_110091_1
AC-1115
CCG-204288
DB00195
SDCCGSBI-0050181.P002
1-[(4-{2-[(cyclopropylmethyl)oxy]ethyl}phenyl)oxy]-3-[(1-methylethyl)amino]propan-2-ol
MRF-0000336
NCGC00015159-04
NCGC00015159-05
NCGC00015159-08
NCGC00015159-09
NCGC00015159-11
NCGC00015159-13
NCGC00015159-14
NCGC00015159-23
NCGC00024863-03
NCGC00024863-04
AS-14125
Cobalt,[(1,2,5,6-h)-1,5-cyclooctadiene][(1,2,3,4,5-h)-1-(trifluoroacetyl)-2,4-cyclopentadien-1-yl]-
FB160758
NS00006058
SW196917-5
C06849
C75987
D07526
SBI-0050181.0001
EN300-18552812
L000125
Q794162
BRD-A02759312-001-02-5
BRD-A02759312-001-03-3
BRD-A02759312-003-03-9
BRD-A02759312-003-11-2
BRD-A02759312-003-23-7
BRD-A02759312-003-24-5
BRD-A02759312-003-25-2
(+/-)-1-(Isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanol
(.+/-.)-1-[p-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)-2-propanol
1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-propanol
1-(4-[2-(Cyclopropylmethoxy)ethyl]phenoxy)-3-(isopropylamino)-2-propanol #
1-[4-(2-(Cyclopropylmethyloxy)ethyl]-phenoxy]-3-[(1-methylethyl)amino]-2-propanol
1-{4-[2-(Cyclopropylmethoxy)ethyl]phenoxy}-3-[(propan-2-yl)amino]propan-2-ol