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Berbamine Hydrochloride

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Identification
Molecular formula
C20H22ClNO4
CAS number
6020-18-4
IUPAC name
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline;hydrochloride
State
State

At room temperature, Berbamine hydrochloride is in a solid state. It is commonly found in a powder form, which is typical for many pharmaceutical compounds, making it suitable for precise measuring and formulation for therapeutic use.

Melting point (Celsius)
198.00
Melting point (Kelvin)
471.15
Boiling point (Celsius)
470.00
Boiling point (Kelvin)
743.15
General information
Molecular weight
413.86g/mol
Molar mass
413.8570g/mol
Density
1.2803g/cm3
Appearence

Berbamine hydrochloride typically appears as a white to off-white crystalline powder. It is known for its crystalline structure, which contributes to its solid form at room temperature.

Comment on solubility

Solubility of 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline;hydrochloride

The solubility of 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline; hydrochloride (C20H22ClNO4) is influenced by various factors, and understanding these can be crucial for practical applications.

This compound is expected to demonstrate:

  • Moderate solubility in water: Due to the presence of the hydrochloride, the compound is more soluble than its base form in aqueous solutions.
  • Enhanced solubility in organic solvents: Compounds such as this often exhibit better solubility in solvents like ethanol, methanol, or DMSO (Dimethyl sulfoxide) due to their organic character.

In terms of specific solubility properties:

  1. pH-dependent behavior: The solubility may vary based on the pH of the solution, which can affect the protonation state of the amine group.
  2. Temperature effects: Generally, increased temperature can lead to higher solubility for many organic compounds.

Overall, the solubility characteristics are essential for determining the bioavailability and efficacy of this compound in various chemical and pharmaceutical applications. Thus, it is advisable to conduct experiments to establish precise solubility data under varying conditions.

Interesting facts

Interesting Facts about 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline; hydrochloride

This unique compound belongs to the isoquinoline class of alkaloids, which are known for their diverse biological activities. Here are some captivating insights about this compound:

  • Biological Significance: Isoquinolines have been the focus of numerous studies due to their potential medicinal properties, including anticancer, analgesic, and antimicrobial effects. This particular compound may share similar benefits.
  • Synthetic Versatility: The compound features multiple functional groups, making it an excellent candidate for further modifications. Organic chemists often explore derivatives to enhance activity or reduce side effects.
  • Research Applications: Owing to its unique structure, this compound is of interest in drug discovery. Its derivatives could lead to the development of new pharmacophores for treating various diseases.
  • Mechanisms of Action: Isoquinoline derivatives are thought to interact with neurotransmitter systems. Understanding how this compound and its derivatives affect serotonin or dopamine levels can provide insights into their neuropharmacological potential.

In the words of a prominent chemist: "The beauty of isoquinoline derivatives lies not only in their structures but also in their profound impacts on human health."
This underscores the importance of continued research into compounds like 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline; hydrochloride, as they hold promise for innovative therapeutic solutions.

Synonyms
PAPAVERINE HYDROCHLORIDE
61-25-6
Cardoverina
Artegodan
Cardiospan
Papaversan
Delapav
Dilaves
Dispamil
Drapavel
Durapav
Dynovas
Forpavin
Pameion
Papacon
Papalease
Pavacen
Pavatest
Paverolan
Paveron
Pavnell
Alapav
Myobid
Vasal
Papaverine Hcl
Pavabid
Ro-Papav
Vaso-Pav
Cepaverin
Pavagrant
Therapav
Cerebid
Optenyl
Pavacap
Pavakey
Pavased
Dipav
Lapav
Papaverinium chloride
Papanerin-hcl
1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride
Spasmo-Nit
Papavarine chlorhydrate
Pap-Kaps-150
Papaverine chlorohydrate
PAP H
Cerespan
vasorin
Papaverine monohydrochloride
Chlorhydrate de papaverine
Papaverine (hydrochloride)
NCI-C56359
CCRIS 3804
6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride
Papaverine, HCl
EINECS 200-502-1
NSC 35443
NSC-35443
UNII-23473EC6BQ
DTXSID9025825
23473EC6BQ
Papaverini hydrochloridum
Isoquinoline, 6,7-dimethoxy-1-veratryl-, hydrochloride
MLS000028497
DTXCID705825
Papaverine.HCl
6,7,3',4'-Tetramethoxy-1-benzylisoquinoline hydrochloride
Papaverine hydrochloride [USP:JAN]
Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-, hydrochloride
MFCD00012745
SMR000058283
NSC35443
Papanerin-HCl [German]
Papaverine hydrochloride (USP:JAN)
PAPAVERINE HYDROCHLORIDE (MART.)
PAPAVERINE HYDROCHLORIDE [MART.]
PAPAVERINE HYDROCHLORIDE (USP-RS)
PAPAVERINE HYDROCHLORIDE [USP-RS]
PAPAVERINE HYDROCHLORIDE (EP MONOGRAPH)
PAPAVERINE HYDROCHLORIDE (USP MONOGRAPH)
PAPAVERINE HYDROCHLORIDE [EP MONOGRAPH]
PAPAVERINE HYDROCHLORIDE [USP MONOGRAPH]
CAS-61-25-6
SR-01000003098
Chlorhydrate de papaverine [French]
NCGC00015810-02
Pamelon
Papaverine hydrochloride [JAN]
Qua bid
Prestwick_376
Pavabid (TN)
component of Copavin
Artegodan; Cepaverin
Papavarine hydrochloride
Papaverine, hydrochloride
Hydrochloride, Papaverine
Opera_ID_1617
REGID_for_CID_6084
MLS001148655
MLS002222208
PAPAVERINE CHLORHYDRATE
CHEMBL98123
SCHEMBL121268
SPECTRUM1500459
Papaverine hydrochloride, powder
HMS1569F08
HMS1920F06
Pharmakon1600-01500459
Tox21_110226
Tox21_500957
CCG-40065
HY-18077A
NSC757256
PAPAVERINE HYDROCHLORIDE [MI]
Papaverine hydrochloride (JP18/USP)
AKOS005111070
Tox21_110226_1
CS-5015
FP26758
LP00957
NSC-757256
PAPAVERINE HYDROCHLORIDE [HSDB]
PAPAVERINE HYDROCHLORIDE [VANDF]
NCGC00015810-12
NCGC00094258-01
NCGC00094258-02
NCGC00094258-03
NCGC00094258-04
NCGC00094258-05
NCGC00094258-06
NCGC00261642-01
PAPAVERINE HYDROCHLORIDE [WHO-DD]
PAPAVERINE HYDROCHLORIDE [WHO-IP]
AS-13262
1-(3,7-dimethoxyisoquinoline hydrochloride
DB-053821
EU-0100957
NS00078975
P0016
6,7-DIMETHOXY-1-VERATRYL HYDROCHLORIDE
D02218
D86684
P 3510
PAPAVERINI HYDROCHLORIDUM [WHO-IP LATIN]
Isoquinoline,7-dimethoxy-1-veratryl-, hydrochloride
Papaverine.HCl, 1mg/ml in Methanol (as free base)
SR-01000003098-2
SR-01000003098-4
SR-01000003098-9
WLN: T66 CNJ B1R CO1 DO1& HO1 IO1 &GH
Q27253713
SR-01000003098-11
6,3',4'-Tetramethoxy-1-benzylisoquinoline hydrochloride
6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline monohydrochloride
Isoquinoline,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, hydrochloride
Papaverine hydrochloride, British Pharmacopoeia (BP) Reference Standard
Papaverine hydrochloride, European Pharmacopoeia (EP) Reference Standard
1-((3,4-DIMETHOXYPHENYL)METHYL)-6,7-DIMETHOXYISOQUINOLINE HYDROCHLORIDE
Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-, hydrochloride (1:1)
Papaverine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Papaverine hydrochloride, United States Pharmacopeia (USP) Reference Standard
200-502-1