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1-[(3,4-dichlorophenyl)methyl]indazole-3-carboxylic acid

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Identification
Molecular formula
C16H10Cl2N2O2
CAS number
844499-71-4
IUPAC name
1-[(3,4-dichlorophenyl)methyl]indazole-3-carboxylic acid
State
State

The compound exists as a solid at room temperature and atmospheric pressure. Its solid form is typically more stable, allowing for convenient handling and storage in laboratory settings.

Melting point (Celsius)
287.00
Melting point (Kelvin)
560.00
Boiling point (Celsius)
450.00
Boiling point (Kelvin)
723.00
General information
Molecular weight
346.17g/mol
Molar mass
346.1690g/mol
Density
1.4680g/cm3
Appearence

The compound typically appears as a crystalline solid and can have color variations ranging from white to off-white or light tan, often depending on its purity and specific crystalline formation.

Comment on solubility

Solubility of 1-[(3,4-dichlorophenyl)methyl]indazole-3-carboxylic acid

The compound 1-[(3,4-dichlorophenyl)methyl]indazole-3-carboxylic acid, with the chemical formula C16H10Cl2N2O2, displays unique solubility characteristics that are influenced by its chemical structure.

General Solubility Insights:

  • The presence of the indazole ring often facilitates limited solubility in polar solvents.
  • Due to the carboxylic acid functional group, it can interact with water molecules through hydrogen bonding, enhancing solubility under certain conditions.
  • However, the presence of the chlorinated phenyl moiety may lead to increased non-polar characteristics, potentially reducing solubility in aqueous media.

As a result, the solubility of this compound may vary significantly based on:

  • Temperature: Higher temperatures often increase solubility.
  • Solvent Type: Polar solvents may enhance solubility, while non-polar solvents could be less effective.
  • pH Levels: The protonation state of the carboxylic acid group can also influence its solubility profile.

In summary, while 1-[(3,4-dichlorophenyl)methyl]indazole-3-carboxylic acid can show improved solubility in polar environments, its overall behavior is a nuanced balance of various molecular interactions and environmental factors.

Interesting facts

Interesting Facts about 1-[(3,4-dichlorophenyl)methyl]indazole-3-carboxylic Acid

1-[(3,4-dichlorophenyl)methyl]indazole-3-carboxylic acid is a fascinating compound that belongs to the indazole family, which are known for their significant biological activities. Here are some intriguing aspects of this compound:

  • Structural Composition: Featuring an indazole core, this compound exhibits both aromatic and heterocyclic characteristics, contributing to its unique chemical behavior.
  • Chlorine Substituents: The presence of chlorines in the phenyl group enhances the compound's lipophilicity, which influences its interaction with biological membranes.
  • Pharmacological Potential: Indazole derivatives have been studied for their potential use in various therapeutic areas, including anti-inflammatory, analgesic, and anticancer activities. This particular compound may exhibit similar promising effects.
  • Synthesis Interest: The multistep synthetic routes often employed to produce this compound showcase the ingenuity of modern synthetic organic chemistry, involving methods like Friedel-Crafts acylation and substitution reactions.
  • Research Impact: Compounds like 1-[(3,4-dichlorophenyl)methyl]indazole-3-carboxylic acid serve as vital tools in medicinal chemistry, allowing researchers to explore structure-activity relationships that dictate biological functions.

In summary, 1-[(3,4-dichlorophenyl)methyl]indazole-3-carboxylic acid is more than just a chemical structure; it embodies the intersection of chemical creativity and biological exploration. As Dr. Marie Curie once said, "Nothing in life is to be feared, it is only to be understood." Each discovery in the field brings us closer to new therapies and a better understanding of nature's complexities.

Synonyms
50264-68-1
1H-Indazole-3-carboxylic acid, 1-(3,4-dichlorobenzyl)-
1-(3,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid
1-[(3,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
BRN 0893050
1-[(3,4-dichlorophenyl)methyl]indazole-3-carboxylic acid
Spectrum3_001854
BSPBio_003268
82E87GTV6D
CHEMBL3276579
SCHEMBL14584216
CHEBI:93699
KBio3_002769
DTXSID30198262
AKOS012405714
NCGC00095232-01
NCGC00095232-02
DB-147147
BRD-K96670504-001-01-9
Q27165396
1-[(3,4-dichlorophenyl)methyl]-3-indazolecarboxylic acid
1H-Indazole-3-carboxylic acid, 1-[(3,4-dichlorophenyl)methyl]-