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Propranolol Hydrochloride

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Identification
Molecular formula
C16H22ClNO2
CAS number
318-98-9
IUPAC name
1-(3,4-dichlorophenyl)-2-(isopropylamino)ethanol;hydrochloride
State
State

At room temperature, propranolol hydrochloride is typically in a solid state, appearing as a powder.

Melting point (Celsius)
162.00
Melting point (Kelvin)
435.15
Boiling point (Celsius)
215.00
Boiling point (Kelvin)
488.15
General information
Molecular weight
295.81g/mol
Molar mass
295.8050g/mol
Density
1.1660g/cm3
Appearence

Propranolol hydrochloride appears as a white, crystalline powder that is odorless. It readily dissolves in water and alcohol but is practically insoluble in ether and chloroform. The substance is known for its bitter taste.

Comment on solubility

Solubility of 1-(3,4-dichlorophenyl)-2-(isopropylamino)ethanol; hydrochloride

The solubility of 1-(3,4-dichlorophenyl)-2-(isopropylamino)ethanol; hydrochloride (C16H22ClNO2) is influenced by its molecular structure and functional groups. Here are some key points regarding its solubility:

  • Polar Characteristics: Being a hydrochloride salt, it is likely to exhibit good solubility in water due to the ionic nature that enhances solvation in polar solvents.
  • Compatibility with Organic Solvents: This compound may have limited solubility in non-polar organic solvents, which is common for many amine and phenolic derivatives.
  • Temperature Dependency: Solubility often increases with temperature; thus, warm conditions may improve the dissolution process.
  • pH Influence: The solubility of hydrochlorides can be affected by pH levels, as acidic conditions may maintain the compound in its soluble ionic form.

In conclusion, while 1-(3,4-dichlorophenyl)-2-(isopropylamino)ethanol; hydrochloride is expected to be soluble in aqueous environments, the presence of specific substituents could also dictate its behavior in varied solvent systems. Overall, understanding the solubility profile is crucial for applications in pharmaceuticals and chemistry.

Interesting facts

Interesting Facts about 1-(3,4-Dichlorophenyl)-2-(isopropylamino)ethanol Hydrochloride

This compound, commonly referred to as a hydrochloride salt, is positioned intriguingly within the realm of medicinal chemistry. Here are some remarkable insights:

  • Pharmacological Activity: This compound is known for its action as a selective serotonin reuptake inhibitor (SSRI), which is pivotal in the treatment of various mood disorders and conditions such as depression. SSRIs work by increasing the levels of serotonin, a neurotransmitter that contributes to feelings of well-being and happiness.
  • Structural Characteristics: The structure of 1-(3,4-dichlorophenyl)-2-(isopropylamino)ethanol features a dichlorophenyl group. This particular arrangement is essential for its pharmacological effects and demonstrates how subtle modifications to a molecular structure can significantly alter a compound's biological activity.
  • Targeting Specific Receptors: The unique characteristics of this molecule allow it to interact selectively with serotonin receptors, emphasizing the importance of receptor specificity in drug design. As a future chemist, understanding these interactions can lead to more effective medicines with fewer side effects.
  • Historical Context: The discovery and development of compounds like this have revolutionized mental health treatment since the late 20th century. Although this specific compound might not be widely known, its chemical framework highlights the evolution of antidepressants over the decades.

In summary, 1-(3,4-dichlorophenyl)-2-(isopropylamino)ethanol hydrochloride exemplifies the intricate relationship between chemistry and pharmacology. As scientists and students delve deeper into the study of such compounds, they uncover not just the mechanics of drug action but also the profound impact these substances have on society.

Synonyms
Dichloroisoproterenol hydrochloride
51-29-6
DCI hydrochloride
Compound 20522
Lilly 20522
1-(3',4'-Dichlorophenyl)-2-isopropylaminoethanol hydrochloride
Dichloroisoprenaline hydrochloride
Dichlorisoproterenol hydrochloride
Dichloroisoproterenol HCl
EINECS 200-088-2
NSC 72104
UNII-XD42620PS5
AI3-52113
XD42620PS5
NSC-72104
beta-Hydroxy-N-isopropyl-3,4-dichloro-phenethylamine hydrochloride
DTXSID401018909
Benzenemethanol, 3,4-dichloro-alpha-(((1-methylethyl)amino)methyl)-, hydrochloride
.beta.-Hydroxy-N-isopropyl-3,4-dichloro-phenethylamine hydrochloride
BENZYL ALCOHOL, 3,4-DICHLORO-alpha-((ISOPROPYLAMINO)METHYL)-, HYDROCHLORIDE
(+/-)-DICHLOROISOPROTERENOL HYDROCHLORIDE
BENZENEMETHANOL, 3,4-DICHLORO-.ALPHA.-(((1-METHYLETHYL)AMINO)METHYL)-, HYDROCHLORIDE (1:1)
1-(3,4-dichlorophenyl)-2-(propan-2-ylamino)ethanol hydrochloride
Benzenemethanol, 3,4-dichloro-alpha-[[(1-methylethyl)amino]methyl]-, hydrochloride (1:1)
BENZENEMETHANOL, 3,4-DICHLORO-ALPHA-(((1-METHYLETHYL)AMINO)METHYL)-, HYDROCHLORIDE (1:1)
WLN: GR BG DYQ1MY &GH
DTXCID901476924
NSC72104
3,4-Dichloro-alpha-((isopropylamino)methyl)benzyl alcohol hydrochloride
AKOS024325898
DB-051937
NS00041151
A828521
Q27293789
1-(3,4-Dichlorophenyl)-2-(isopropylamino)ethanol hydrochloride
1-(3,4-dichlorophenyl)-2-(propan-2-ylamino)ethanol;hydrochloride
Benzyl alcohol,4-dichloro-.alpha.-[(isopropylamino)methyl]-, hydrochloride
Benzenemethanol, 3,4-dichloro-alpha-(((1-methylethyl)amino)methyl)-, hydrochloride (9CI)
Benzenemethanol,4-dichloro-.alpha.-[[(1-methylethyl)amino]methyl]-, hydrochloride
200-088-2