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Berbamine

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Identification
Molecular formula
C37H40N2O6
CAS number
478-61-5
IUPAC name
1-[(3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl)methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol
State
State
Berbamine is typically a solid at room temperature, appearing in a crystalline form. It is stable under normal conditions and must be handled with care in a laboratory setting.
Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
494.20
Boiling point (Kelvin)
767.35
General information
Molecular weight
592.73g/mol
Molar mass
592.7250g/mol
Density
1.2400g/cm3
Appearence
Berbamine appears as an off-white to pale yellow crystalline powder. It is not very soluble in water but dissolves in ethanol and other organic solvents. The compound is naturally occurring and is found primarily in various plant species, particularly within the Berberidaceae family.
Comment on solubility

Solubility of 1-[(3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl)methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol

The solubility of the compound with the chemical formula C37H40N2O6 is an interesting topic, as it embodies a variety of factors contributing to its behavior in different solvents. Its complex structure, containing multiple methoxy groups and aromatic systems, can significantly affect its solubility characteristics.

Factors Influencing Solubility

Several key factors can determine the solubility of this compound:

  • Molecular Structure: The presence of polar functional groups, such as methoxy (-OCH3) groups, can improve solubility in polar solvents.
  • Hydrophobic Regions: The large hydrophobic aromatic and aliphatic portions may contribute to decreased solubility in water.
  • Temperature: Increased temperature typically increases solubility for many organic compounds, and this may apply here as well.
  • Solvent Type: Solubility can vary greatly between organic solvents such as ethanol, methanol, or dichloromethane. It is essential to consider the solvent's polarity and ability to stabilize the solute.

Potential Solubility Outcomes

Given its structure, one might anticipate the following solubility behaviors:

  • This compound may be poorly soluble in water due to its non-polar characteristics.
  • In contrast, it could exhibit higher solubility in organic solvents with similar polarities.
  • Alterations in pH or the presence of co-solvents may significantly influence its dissolution properties.

In summary, the solubility of the compound is expected to be intriguing, in that it likely possesses a dual nature that can switch between hydrophobic and hydrophilic characteristics depending on environmental conditions.

Interesting facts

Interesting Facts about 1-[(3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl)methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol

This compound is a fascinating example of molecular creativity within the realm of organic chemistry. It belongs to a class of compounds that are known for their potential therapeutic properties. Here are some key points to consider:

  • Diverse Structure: The complex structure features a combination of benzoquinolizine and tetrahydroisoquinoline frameworks. This dual structure could help in understanding various biological mechanisms.
  • Potential Applications: Compounds of this category often exhibit a wide array of biological activities, such as anti-inflammatory, analgesic, and neuroprotective effects. Researchers are continually exploring their potential as pharmaceuticals.
  • Natural Inspirations: Many such compounds are synthesized based on natural products. The intricate scaffolding and substitutions may mimic structures found in nature and could lead to significant discoveries.
  • Research Importance: The ongoing studies of compounds like this one are crucial for drug discovery. They can elucidate pathways of action and identify new therapeutic targets.

Moreover, scientists are intrigued by how small alterations in the structure can result in vastly different biological properties. This emphasizes the importance of structure-activity relationships (SAR) in medicinal chemistry. Understanding these relationships can revolutionize drug design, leading to more effective treatments.

In summary, this compound represents a small but significant piece of the puzzle in the vast landscape of chemical compounds, showcasing the endless possibilities that arise from organic synthesis and its implications in medicine.

Synonyms
Desmethylemetine
1-[(3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl)methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol
SCHEMBL13912580
DTXSID00862004
CHEBI:181712
AKOS037514580
(R)-1-(((2S,3R,11bS)-3-Ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl)methyl)-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol
10159-64-5