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Histidylproline

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Identification
Molecular formula
C15H21N5O5
CAS number
1145-32-0
IUPAC name
1-[3-(1H-imidazol-5-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carboxylic acid
State
State

At room temperature, Histidylproline is typically in a solid state. It is stable under normal conditions but should be kept away from strong oxidizing agents and excessive moisture, as it is slightly hygroscopic.

Melting point (Celsius)
184.00
Melting point (Kelvin)
457.15
Boiling point (Celsius)
264.00
Boiling point (Kelvin)
537.15
General information
Molecular weight
374.36g/mol
Molar mass
374.3830g/mol
Density
1.4300g/cm3
Appearence

Histidylproline appears as a white to off-white crystalline powder. It is usually odorless and stable under standard conditions. The substance is hygroscopic and should be handled in a closed container to prevent absorption of moisture from the atmosphere.

Comment on solubility

Solubility of 1-[3-(1H-imidazol-5-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carboxylic acid (C15H21N5O5)

The solubility of this complex organic compound is an intriguing subject, particularly due to its multifaceted structure. Several factors influence its solubility, which can exhibit varying behaviors in different solvents. Here's a breakdown of key points regarding its solubility:

  • Polarity: With multiple functional groups such as imidazole and carboxylic acid, the polarity of the molecule significantly affects solubility in polar solvents like water.
  • Hydrogen bonding: The presence of hydrogen bond donors and acceptors may enhance solubility in aqueous solutions, as these interactions facilitate better dissolution.
  • pH dependency: Given the acidic nature of the carboxylic group, the solubility can vary with pH. In alkaline conditions, deprotonation may occur, which could enhance solubility further.
  • Solvent choices: The compound may show better solubility in organic solvents such as dimethyl sulfoxide (DMSO) or methanol compared to water, primarily due to its nonpolar regions.

In conclusion, while the solubility of 1-[3-(1H-imidazol-5-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carboxylic acid can be predicted based on its functional groups, empirical testing in various conditions will yield a clearer understanding of its solubility characteristics.

Interesting facts

Interesting Facts about 1-[3-(1H-imidazol-5-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carboxylic acid

This intriguing compound is a derivative of both imidazole and pyrrolidine, which places it within an exciting class of molecules that have garnered considerable attention in medicinal chemistry. Here are some fascinating aspects of this compound:

  • Pharmacological Potential: Compounds like this one have shown promise in the development of novel therapeutics. The presence of the imidazole ring often indicates activity against diseases related to inflammation and infection.
  • Structural Complexity: The incorporation of multiple functional groups, including a carboxylic acid and an oxopyrrolidine moiety, provides a rich tapestry of reactivity and interaction possibilities, enabling research into various biochemical pathways.
  • Role in Drug Design: The unique structure allows scientists to explore its potential as a bioactive molecule, influencing areas such as enzyme inhibition or receptor activity.
  • Synthetic Challenges: The synthesis of such complex compounds often involves multistep procedures with careful optimization to achieve desired yields and purity.
  • Research Applications: This compound can serve as a crucial building block in the synthesis of larger biomolecules, making it a valuable asset in chemical biology.

In conclusion, 1-[3-(1H-imidazol-5-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carboxylic acid exemplifies the exciting potential that exists within synthetic organic chemistry. The ongoing exploration of its properties may pave the way for groundbreaking developments in pharmaceuticals and therapeutic interventions.

Synonyms
Pglu-his-pro
24769-58-2
Trh-OH
PGlu-3-methyl-His-Pro-NH2
A-42872
TRH (free acid) Pyr-His-Pro-OH
BCP23913
AKOS040759127
FT109399
1-[3-(1H-imidazol-4-yl)-2-[(5-oxopyrrolidin-2-yl)formamido]propanoyl]pyrrolidine-2-carboxylic acid