Skip to main content

Thymidine

ADVERTISEMENT
Identification
Molecular formula
C10H14N2O5
CAS number
50-89-5
IUPAC name
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
State
State

At room temperature, thymidine is a solid. It is stable and typically stored in a cool, dry place to maintain its integrity.

Melting point (Celsius)
185.00
Melting point (Kelvin)
458.20
Boiling point (Celsius)
275.50
Boiling point (Kelvin)
548.70
General information
Molecular weight
242.23g/mol
Molar mass
242.2290g/mol
Density
1.4570g/cm3
Appearence

Thymidine appears as a white crystalline powder. It is typically odorless and is often handled under controlled conditions to prevent contamination from moisture or other substances.

Comment on solubility

Solubility of 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione

The solubility of a chemical compound can greatly influence its potential applications in various fields, particularly in pharmaceuticals and biochemistry. For the compound with the formula C10H14N2O5, the solubility characteristics can be summarized as follows:

  • Polarity: Presence of multiple functional groups, including the hydroxyl (-OH) groups, suggests that this compound may exhibit relatively high polarity, which typically enhances solubility in polar solvents such as water.
  • Solvent Compatibility: In addition to water, this compound may also be soluble in other polar organic solvents like methanol and ethanol, allowing for versatility in use.
  • Temperature Effects: Solubility can be temperature dependent, and it is anticipated that the solubility in solvents increases with rising temperatures.
  • Hydrogen Bonding: The presence of hydroxyl groups allows for hydrogen bonding, which can significantly affect solubility, potentially enabling better interaction with aqueous environments.

In summary, while the exact solubility values can vary, one should expect that this compound possesses a good degree of solubility in polar solvents, making it a versatile candidate for various chemical and biological applications. As with many chemical substances, practical solubility tests in multiple solvents will provide clearer insights into its behavior.

Interesting facts

Interesting Facts about 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione

This intriguing compound serves as a fascinating example within the realm of organic chemistry, displaying a complex structure with significant biological implications. It is a versatile chemical primarily known for its role as a building block in the synthesis of various pharmaceuticals, particularly in the field of medicinal chemistry.

Key Characteristics and Applications:

  • Structural Complexity: The compound features a unique arrangement that includes both a pyrimidine and a tetrahydrofuran ring, contributing to its functional diversity.
  • Biological Activity: Research indicates that compounds of this type may exhibit antitumor properties, making them potential candidates for cancer treatment.
  • Synthesis: It can be derived through several synthetic pathways, showcasing the ingenuity of chemists in molecular design.
  • Research Potential: Ongoing studies are focused on its mechanisms of action, exploring how modifications to this structure can enhance its therapeutic efficacy.

Notably, the stereochemistry of this compound, indicated by its specific (R,S) configurations, plays a crucial role in determining its activity and interaction with biological targets. As a result, understanding these stereochemical aspects can lead to advancements in drug development.

In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This quote resonates with the ongoing exploration of compounds like this, where diverse structural modifications could yield a plethora of new, biologically active substances.

With its multifaceted nature and significant implications for human health, this compound exemplifies the intersection of chemistry and medicine, embodying the pursuit of knowledge and discovery in the ever-evolving world of chemical science.

Synonyms
thymidine
50-89-5
deoxythymidine
2'-Deoxythymidine
Thymidin
5-Methyldeoxyuridine
Beta-Thymidine
DThyd
5-Methyl-2'-deoxyuridine
5-Methyldeoxyurindine
Thymine-2-desoxyriboside
Thyminedeoxyriboside
Thymine-2-deoxyriboside
Thymine deoxyriboside
dThd
Uridine, 2'-deoxy-5-methyl-
Deoxyribothymidine
2'-thymidine
Doxribtimine
thymine 2'-deoxyriboside
1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2'-deoxy-5-methyluridine
AI3-52267
beta-D-Ribofuranoside, thymine-1 2-deoxy-
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
CCRIS 1283
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
157049-39-3
dT
Thymine 2-desoxyriboside
CHEBI:17748
UNII-VC2W18DGKR
2'deoxythymidine
deoxyribosylthymine
EINECS 200-070-4
MFCD00006537
NSC 21548
Thymidinedeoxyriboside
1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methyl-
DTXSID5023661
THYMIDINE [MI]
VC2W18DGKR
DOXRIBTIMINE [INN]
THYMIDINE [MART.]
THYMIDINE [WHO-DD]
THYMIDINE [WHO-IP]
2'-deoxy-5-methyl-Uridine
DTXCID703661
EC 200-070-4
1-(2-Deoxy-beta-D-ribofuranosyl)-5-methyluracil
NSC-21548
STAVUDINE IMPURITY C [WHO-IP]
thymine-1 2-deoxy-b-D-Ribofuranoside
[3H]-Thymidine
NCGC00142484-03
STAVUDINE IMPURITY C [EP IMPURITY]
ZIDOVUDINE IMPURITY E [EP IMPURITY]
thymine-1 2-deoxy-beta-delta-Ribofuranoside
THYMIDINE (MART.)
alpha-tritiated thymidine
146183-25-7
THM
1-(2-Deoxy-.beta.-D-ribofuranosyl)-5-methyluracil
1-(2-Deoxy-b-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione (Thymidine)
1-(2-Deoxy-beta-delta-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
157049-40-6
STAVUDINE IMPURITY C (EP IMPURITY)
ZIDOVUDINE IMPURITY E (EP IMPURITY)
1-(4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-methyl-pyrimidine-2,4-dione
4qsv
1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-methylpyrimidine-2,4-dione
5Methyldeoxyuridine
1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Thymine2deoxyriboside
Thymidine (Standard)
Thymine2desoxyriboside
5Methyl2'deoxyuridine
beta-Methyldeoxyuridine
1w2g
Thymidine, >=99%
BDBM1
THYMIDINE [INCI]
Thymidine (8CI,9CI)
Uridine, 2'deoxy5methyl
Doxribtimine (USAN/INN)
bmse000244
Epitope ID:138113
DOXRIBTIMINE [USAN]
STAVUDINE IMPURITY C
SCHEMBL19894
50-88-4
2'-dT
CHEMBL52609
GTPL4718
HY-N1150R
IMPURITY C [EP IMPURITY]
MT1621 (dT)
HY-N1150
STR05630
Thymidine, >=99.0% (HPLC)
Tox21_111560
betaDRibofuranoside, thymine1 2deoxy
HG1139
s4803
AKOS015895360
AC-1475
CCG-266886
CS-W019644
DB04485
NT02592
CAS-50-89-5
1(2DeoxybetaDribofuranosyl)5methyluracil
DEOXYTHYMIDINE; 2'-DEOXYTHYMIDINE
dT; 2-dT; Deoxythymidine; Doxribtimine
NCGC00142484-01
1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-furan-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
1-(2-Deoxy-beta-D-ribofuranosyl)thymine
1-[(4S,2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,3-dihydropyri midine-2,4-dione
BP-58693
Thymidine, Vetec(TM) reagent grade, 99%
DB-030432
NS00068173
T0233
MT-1621 COMPONENT 2'-DEOXYTHYMIDINE
1-(2-Deoxy-beta-ribofuranosyl)-5-methyluracil
C00214
D12466
EN300-378408
Q422464
SR-01000883981
SR-01000883981-1
BRD-K28309349-001-02-4
Q27124084
D7E43A69-265B-4DAA-BC8F-193FB357140F
Thymidine, powder, BioReagent, suitable for cell culture
Z1741976665
1(2DeoxybetaDerythropentofuranosyl)5methyl2,4(1H,3H)pyrimidinedione
2,4(1H,3H)Pyrimidinedione, 1(2deoxybetaDerythropentofuranosyl)5methyl
1-(2-Deoxy-b-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
1-(2-Deoxy-I2-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
1-(2-DEOXY-.BETA.-D-ERYTHRO-PENTOFURANOSYL)-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE [WHO-IP]
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
1211376-53-2