Skip to main content

1-[2-(trifluoromethyl)phenyl]imidazole

ADVERTISEMENT
Identification
Molecular formula
C10H7F3N2
CAS number
219864-88-1
IUPAC name
1-[2-(trifluoromethyl)phenyl]imidazole
State
State

At room temperature, 1-[2-(trifluoromethyl)phenyl]imidazole is in a solid state, typically found as a crystalline powder.

Melting point (Celsius)
52.00
Melting point (Kelvin)
325.15
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.00
General information
Molecular weight
198.17g/mol
Molar mass
198.1680g/mol
Density
1.3254g/cm3
Appearence

1-[2-(trifluoromethyl)phenyl]imidazole typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 1-[2-(trifluoromethyl)phenyl]imidazole (C10H7F3N2)

The solubility of 1-[2-(trifluoromethyl)phenyl]imidazole is influenced by its molecular structure and the presence of the highly electronegative trifluoromethyl group. The solubility exhibits unique characteristics that can be summarized as follows:

  • Polar vs Non-Polar Solvents: This compound is generally more soluble in polar solvents due to the ability of the imidazole ring to form hydrogen bonds with solvent molecules.
  • Temperature Influence: As with many organic compounds, an increase in temperature typically enhances solubility; thus, heating the solvent may aid in dissolving the compound.
  • Solubility Product: The presence of the trifluoromethyl group often influences the solubility product, making it less soluble in water compared to other, less substituted derivatives.
  • Hydrophobic Characteristics: The large size and electronegativity of fluorine atoms contribute to a degree of hydrophobicity, leading to limited solubility in aqueous solutions.

It is important to note that while predicting solubility can be complex, understanding the molecular interactions involved provides valuable insights into the compound's behavior in various environments. As stated, "like dissolves like," making the choice of solvent crucial when attempting to dissolve 1-[2-(trifluoromethyl)phenyl]imidazole.

Interesting facts

Interesting Facts About 1-[2-(trifluoromethyl)phenyl]imidazole

1-[2-(trifluoromethyl)phenyl]imidazole is a fascinating compound in the world of organic chemistry, attributed to its unique structure and multifunctional properties. Here are some intriguing insights:

  • Chemical Structure: The presence of the CF3 group significantly influences the compound's reactivity and properties, giving it unique characteristics that can be exploited in various applications.
  • Pharmaceutical Relevance: This compound is of particular interest in medicinal chemistry due to its potential role in drug development. The imidazole moiety is often found in various bioactive compounds, making it a valuable scaffold in pharmaceutical research.
  • Favorable Properties: The trifluoromethyl group is renowned for enhancing the metabolic stability of compounds. This can lead to improved efficacy and reduced degradation in biological systems.
  • Biological Activity: Compounds containing imidazole rings have been shown to exhibit a wide range of biological activities, including antifungal, anti-inflammatory, and enzyme inhibition. The presence of such a structure in this compound suggests potential therapeutic uses.
  • Industrial Applications: Beyond pharmaceuticals, it can also be utilized in agrochemicals and polymers, highlighting its versatility across different fields of study.

As a compound with a trifluoromethyl substituent and an imidazole core, 1-[2-(trifluoromethyl)phenyl]imidazole represents a bridge between classical organic compounds and modern synthetic applications. Its ability to influence biological pathways while offering diverse industrial applications makes it a compelling subject for ongoing research.

In summary, the exploration of this compound continues to reveal its significance within various fields, emphasizing the role of chemistry in advancing science and technology.

Synonyms
Trim
25371-96-4
1-(2-Trifluoromethylphenyl)imidazole
1-[2-(trifluoromethyl)phenyl]imidazole
1-(2-(Trifluoromethyl)phenyl)-1H-imidazole
1-TRIM
1-[2-(Trifluoromethyl)phenyl]-1H-imidazole
DTXSID9045217
MFCD00041206
CHEMBL277525
DTXCID7025217
1-[2-(trifluoromethyl)phenyl] imidazole
NCGC00016047-03
1H-Imidazole,1-[2-(trifluoromethyl)phenyl]-
1H-Imidazole, 1-(2-(trifluoromethyl)phenyl)-
CAS-25371-96-4
SR-01000076173
Tocris-0919
Lopac-T-7313
Lopac0_001200
BSPBio_001344
BSPBio_002476
KBioGR_000064
KBioSS_000064
MLS002153350
SPECTRUM1505102
GTPL4331
SCHEMBL1322071
KBio2_000064
KBio2_002632
KBio2_005200
KBio3_000127
KBio3_000128
CHEBI:109530
MCQMXTRZXRENNR-UHFFFAOYSA-N
Bio2_000064
Bio2_000544
HMS1361D06
HMS1791D06
HMS1989D06
HMS2231J13
HMS3263P21
HMS3267C09
HMS3373H08
HMS3402D06
HMS3411H10
HMS3675H10
Tox21_110289
Tox21_501200
BDBM50099401
1-(2-trifluoromethylphenyl) imidazole
AKOS015852668
Tox21_110289_1
2-(trifluoromethyl)phenyl-1H-imidazole
CCG-205274
LP01200
PS-7992
SDCCGSBI-0051167.P002
IDI1_033814
NCGC00016047-01
NCGC00016047-02
NCGC00016047-04
NCGC00016047-05
NCGC00016047-06
NCGC00016047-07
NCGC00016047-08
NCGC00016047-09
NCGC00016047-11
NCGC00016047-15
NCGC00024873-01
NCGC00024873-02
NCGC00024873-03
NCGC00024873-04
NCGC00024873-05
NCGC00024873-06
NCGC00024873-07
NCGC00261885-01
SMR001230755
1-(2-Trifluoromethyl-phenyl)-1H-imidazole
DB-018471
HY-101316
CS-0021141
EU-0101200
T2982
1-[2-(Trifluoromethyl)phenyl]-1H-imidazole #
T 7313
T72172
SR-01000076173-1
SR-01000076173-3
BRD-K36851334-001-03-0
BRD-K36851334-001-05-5
BRD-K36851334-001-11-3
BRD-K36851334-001-12-1
Q27089025
2-(1H-Imidazol-1-yl)benzotrifluoride, 1-(1H-Imidazol-1-yl)-2-(trifluoromethyl)benzene
636-734-9