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Tinidazole

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Identification
Molecular formula
C8H13N3O4S
CAS number
19387-91-8
IUPAC name
1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole
State
State

At room temperature, Tinidazole is in a solid state. It is stable under normal environmental conditions.

Melting point (Celsius)
125.00
Melting point (Kelvin)
398.00
Boiling point (Celsius)
285.00
Boiling point (Kelvin)
558.00
General information
Molecular weight
247.27g/mol
Molar mass
247.2740g/mol
Density
1.6000g/cm3
Appearence

Tinidazole appears as a crystalline powder. It is usually off-white to pale yellow in color and is practically odorless.

Comment on solubility

Solubility of 1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole

The solubility of 1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole, with the chemical formula C8H13N3O4S, can be influenced by various factors due to its complex structure. Here are some key points regarding its solubility:

  • Polarity: The presence of the sulfonyl group and nitro group contributes to the overall polarity of the compound, potentially enhancing its solubility in polar solvents.
  • Solvent Interaction: It is expected to be more soluble in solvents like dimethyl sulfoxide (DMSO) or water than in nonpolar solvents.
  • Hydrogen Bonding: The -OH or -NH functionalities (if present in other structural isomers) may engage in hydrogen bonding, further promoting solubility in aqueous solutions.
  • Temperature Dependency: As with many organic compounds, solubility may increase with temperature, leading to enhanced dissolution rates.

The combination of these factors can create varying solubility characteristics that are critical for practical applications such as drug formulation and synthesis. A thorough understanding of its solubility profile is essential for optimizing its usage in both research and industry.

Interesting facts

Interesting Facts About 1-(2-Ethylsulfonylethyl)-2-methyl-5-nitro-imidazole

1-(2-Ethylsulfonylethyl)-2-methyl-5-nitro-imidazole, a compound within the imidazole family, presents a fascinating profile that is of great interest in both chemistry and pharmacology. Here are some key aspects to consider:

  • Structural Complexity: This compound features an imidazole ring, which is a five-membered ring consisting of three carbon atoms and two nitrogen atoms. Its unique nitrogen-containing heterocyclic structure contributes to a range of chemical reactivities.
  • Biological Activity: Imidazole derivatives are known to participate in various biological activities, making them pivotal in the fields of medicinal chemistry. This specific compound may exhibit properties similar to other nitroimidazole compounds, which are often employed as antimicrobial agents.
  • Sulfonyl Group Influence: The presence of the sulfonyl (−SO₂) group adjacent to the imidazole structure enhances the compound's solubility and may influence its interaction with biological molecules. This functional group is often associated with a variety of pharmacological activities.
  • Research Potential: Ongoing research is revealing the potential therapeutic roles of imidazole derivatives, including fungicidal and antiprotozoal effects. Their mechanisms of action often involve interference with essential cellular processes.
  • Applications in Therapy: Due to their broad spectrum of activity, compounds engineered from imidazole structures, including this one, are being explored for use in treating infections, particularly those caused by protozoa and anaerobic bacteria.

In conclusion, 1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole exemplifies the intriguing interplay between structure and function in organic chemistry. As researchers continue to explore its properties, the implications for drug development and therapeutic applications remain promising.

Synonyms
tinidazole
19387-91-8
Tindamax
Trimonase
Fasigyn
Tinidazol
Fasigin
Tricolam
1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitro-1H-imidazole
Simplotan
Sorquetan
Tinidazolum
Pletil
timidazole
Glongyn
Haisigyn
Protozol
Amtiba
1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole
1-[2-(Ethylsulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole
1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-
CP 12574
CCRIS 7621
CHEBI:63627
HSDB 7362
CP-12574
Tinidazol [INN-Spanish]
Tinidazolum [INN-Latin]
1-[2-(ethanesulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole
CP-12,574
EINECS 243-014-4
1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitroimidazole
NSC-758189
UNII-033KF7V46H
BRN 0618182
1H-Imidazole, 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-
DTXSID4023676
033KF7V46H
Ethyl (2-(2-methyl-5-nitro-1-imidazolyl)ethyl)sulfone
MLS000069717
DTXCID003676
148159-84-6
Bioshik
5-23-05-00067 (Beilstein Handbook Reference)
1-[2-(Ethylsulfonyl)ethyl]-2-methyl-5-nitroimidazole
NSC 758189
Tinidazole [USAN:USP:INN:BAN:JAN]
Imidazole, 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-
NCGC00016741-01
SMR000058194
Tinidazole 100 microg/mL in Acetonitrile
CAS-19387-91-8
Tinidazol (INN-Spanish)
Tinidazolum (INN-Latin)
TINIDAZOLE (MART.)
TINIDAZOLE [MART.]
TINIDAZOLE (USP-RS)
TINIDAZOLE [USP-RS]
TINIDAZOLE (EP MONOGRAPH)
TINIDAZOLE [EP MONOGRAPH]
TINIDAZOLE (USP MONOGRAPH)
TINIDAZOLE [USP MONOGRAPH]
IMIDAZOLE, 1-(2-(ETHYLSULFONYL)ETHYL)-2-METHYL-4-NITRO-
Tinidazole (USAN:USP:INN:BAN:JAN)
SR-01000000210
tinidazolo
Symplotan
Tindazole
Fasigyntrade mark
Tindamaxtrade mark
Tinidazole,(S)
Simplotantrade mark
Haisigyn (TN)
Tindamax (TN)
Prestwick_136
MFCD00057217
Tinidazole (Standard)
Spectrum_001266
Opera_ID_779
SpecPlus_000708
TINIDAZOLE [MI]
TINIDAZOLE [INN]
TINIDAZOLE [JAN]
Prestwick0_000766
Prestwick1_000766
Prestwick2_000766
Prestwick3_000766
Spectrum2_000648
Spectrum3_001512
Spectrum4_000230
Spectrum5_001715
TINIDAZOLE [HSDB]
TINIDAZOLE [USAN]
TINIDAZOLE [VANDF]
CHEMBL1220
TINIDAZOLE [WHO-DD]
Oprea1_342844
SCHEMBL21141
BSPBio_000812
BSPBio_003183
KBioGR_000899
KBioSS_001746
methyl-5-nitro-1H-imidazole
MLS001146883
MLS001424192
DivK1c_006804
SPECTRUM1502127
1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole
SPBio_000655
SPBio_002751
BPBio1_000894
Tinidazole (JP17/USP/INN)
1-(ethylsulfonyl)-2-(2-methyl-5-nitroimidazolyl)ethane
TINIDAZOLE [ORANGE BOOK]
GTPL12341
HY-B0177R
KBio1_001748
KBio2_001746
KBio2_004314
KBio2_006882
KBio3_002683
J01XD02
MSK5579
P01AB02
1-(2-(ethylsulfonyl)ethyl)-2-
HMS1570I14
HMS1921L06
HMS2052C09
HMS2090B14
HMS2092D14
HMS2097I14
HMS2231E23
HMS3374P07
HMS3394C09
HMS3652A08
HMS3714I14
Pharmakon1600-01502127
BCP20694
HY-B0177
Tox21 110586
Tox21_110586
BBL010767
BDBM50248360
CCG-39907
NSC758189
s4068
STK801761
AKOS000747070
Tox21_110586_1
AC-1618
CS-2055
DB00911
FT28285
KS-5180
MCULE 2580495783
NC00346
NCGC00016741-02
NCGC00016741-03
NCGC00016741-04
NCGC00016741-05
NCGC00016741-06
NCGC00016741-07
NCGC00016741-09
NCGC00022212-03
NCGC00022212-04
NCGC00022212-05
SBI-0052674.P002
AB00053176
NS00010248
SW196447-4
T3058
VU0239922-6
D01426
EN300-119371
Tinidazole, VETRANAL(TM), analytical standard
AB00053176-16
AB00053176_17
AB00053176_18
Q1321320
SR-01000000210-3
SR-01000000210-5
SR-01000000210-6
BRD-K89125793-001-05-4
BRD-K89125793-001-25-2
BRD-K89125793-001-26-0
BRD-K89125793-001-27-8
Z56763819
1-(2'-(ethylsulfonyl)-Ethyl]-2-Methyl-5-Nitroimidazole
Tinidazole, European Pharmacopoeia (EP) Reference Standard
Tinidazole, United States Pharmacopeia (USP) Reference Standard
1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-, radical ion(1-)
243-014-4
TIMTEC-BB SBB006917 TINIDAZOLE 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-1h-imidazol