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1-[(2-chlorophenyl)methyl]-2,3-dimethylguanidine

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Identification
Molecular formula
C11H15ClN2
CAS number
174818-18-9
IUPAC name
1-[(2-chlorophenyl)methyl]-2,3-dimethyl-guanidine
State
State

At room temperature, this compound is typically found in a solid state. The solid form is stable under normal conditions of storage and handling.

Melting point (Celsius)
75.00
Melting point (Kelvin)
348.15
Boiling point (Celsius)
335.00
Boiling point (Kelvin)
608.15
General information
Molecular weight
211.70g/mol
Molar mass
211.7040g/mol
Density
1.1567g/cm3
Appearence

The compound 1-[(2-chlorophenyl)methyl]-2,3-dimethylguanidine appears as a colorless to pale yellow crystalline solid. It may have a slight odor depending on its purity and storage conditions.

Comment on solubility

Solubility of 1-[(2-chlorophenyl)methyl]-2,3-dimethyl-guanidine (C11H15ClN2)

The solubility of 1-[(2-chlorophenyl)methyl]-2,3-dimethyl-guanidine can be influenced by various factors including its molecular structure, polarity, and the presence of functional groups. Here are some key points to consider:

  • Polar vs Nonpolar: The presence of the -Cl (chlorine) and amino groups can enhance polarity, potentially increasing solubility in polar solvents.
  • Organic Solvent Compatibility: Compounds like this guanidine derivative generally show good solubility in common organic solvents such as ethanol and dimethyl sulfoxide (DMSO).
  • Aqueous Solubility: Aqueous solubility can be limited due to the hydrophobic characteristics introduced by the chlorophenyl group. This often results in low solubility in water.
  • Temperature Effects: Increasing temperature may enhance solubility for some compounds, particularly if they are not highly soluble at room temperature.

As such, when assessing the solubility of C11H15ClN2, it is recommended to consider the solvent environment and conditions, as the compound's unique structure plays a significant role in its interaction with solvents.

Interesting facts

Interesting Facts About 1-[(2-chlorophenyl)methyl]-2,3-dimethyl-guanidine

1-[(2-chlorophenyl)methyl]-2,3-dimethyl-guanidine is a fascinating compound that falls into the category of guanidine derivatives. Here are some key points to consider:

  • Pharmaceutical Applications: This compound has been studied for its potential use in various pharmaceutical applications, particularly as a part of medicinal chemistry research aimed at developing new therapeutic agents.
  • Structural Features:
    • The presence of the chlorophenyl group enhances its biological activity, making it a subject of interest for researchers.
    • The dimethyl substitution at positions 2 and 3 contributes to the compound's unique reactivity and interaction with biological targets.
  • Mechanism of Action: The guanidine moiety is known for its properties as a *strong base* and can participate in various reactions, making this compound a versatile intermediate in organic synthesis.
  • Research Potential: Ongoing studies are exploring how modifications to this scaffold can lead to improved efficacy and reduced side effects in drug candidates.
  • Biological Activity: Initial research suggests that compounds of similar structure exhibit *antimicrobial* and *antidiabetic* properties, showcasing the diverse biological activities associated with guanidine derivatives.

As a chemistry student or researcher, understanding compounds like 1-[(2-chlorophenyl)methyl]-2,3-dimethyl-guanidine is crucial not only for grasping fundamental concepts in organic chemistry but also for appreciating the intricate relationship between chemical structure and biological activity. As stated by renowned chemist Linus Pauling, “The best way to have a good idea is to have lots of ideas.” Engaging with such compounds can ignite new thoughts and innovations in the field of drug design.

Synonyms
51-13-8
Guanidine, 1-(o-chlorobenzyl)-2,3-dimethyl-
BW 392C60
1-[(2-chlorophenyl)methyl]-2,3-dimethylguanidine
Chlorobethanidine
Chlorobetanidine
SCHEMBL973274
CHEMBL4941091
NIOSH/ME9300000
DTXSID00198996
Guanidine, N-((2-chlorophenyl)methyl)-N',N''-dimethyl-
2-(o-Chlorobenzyl)-1,3-dimethylguanidine
ME93000000
Guanidine, 2-(o-chlorobenzyl)-1,3-dimethyl-