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Sufentanil

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Identification
Molecular formula
C22H30ClN3O2
CAS number
56030-54-7
IUPAC name
1-(2-chlorophenyl)-N-methyl-N-sec-butyl-isoquinoline-3-carboxamide
State
State

At room temperature, sufentanil is typically encountered as a solid.

Melting point (Celsius)
104.50
Melting point (Kelvin)
377.65
Boiling point (Celsius)
298.40
Boiling point (Kelvin)
571.55
General information
Molecular weight
387.90g/mol
Molar mass
387.8960g/mol
Density
1.2550g/cm3
Appearence

Sufentanil is a white to off-white crystalline solid and is highly lipophilic.

Comment on solubility

Solubility of 1-(2-chlorophenyl)-N-methyl-N-sec-butyl-isoquinoline-3-carboxamide

The solubility of the compound 1-(2-chlorophenyl)-N-methyl-N-sec-butyl-isoquinoline-3-carboxamide with the formula C22H30ClN3O2 can be influenced by several factors:

  • Polarity: This compound features both hydrophobic and polar functional groups, which can affect its ability to dissolve in various solvents.
  • Temperature: Generally, increased temperature may enhance the solubility of organic compounds, but the specific effect must be determined experimentally.
  • Solvent Type: The solubility is expected to be higher in organic solvents such as ethanol or dimethyl sulfoxide (DMSO) compared to water, due to the hydrophobic isopropyl and isoquinoline portions.

It is crucial to remember that the solubility of such organic compounds often exhibits a significant variation based on the solvent and the conditions under which the measurements are taken. As stated in solubility theory, "like dissolves like"; therefore, the non-polar characteristics will favor solubility in non-polar environments.

Researchers should prepare to conduct solubility tests in various conditions to fully understand the behavior of this compound in different environments.

Interesting facts

Interesting Facts about 1-(2-chlorophenyl)-N-methyl-N-sec-butyl-isoquinoline-3-carboxamide

This compound, recognized by its complex name, is part of a class of chemicals known as isoquinoline derivatives, which are renowned for their diversity in biological activities. Here are some fascinating insights into this compound:

  • Pharmacological Interest: Isoquinoline derivatives have garnered significant interest in medicinal chemistry due to their potential as therapeutic agents. They exhibit various biological properties such as anti-inflammatory, analgesic, and anticancer effects.
  • Structural Complexity: The unique structure of this compound, featuring a chlorophenyl group, a methyl group, and a sec-butyl group, indicates a high level of structural diversity that can influence its interaction with biological targets.
  • Targeted Action: Compounds like this one are often explored for their ability to interact with specific receptors or enzymes in the body, leading to the development of drug candidates with targeted actions.
  • Research Applications: Ongoing research may focus on evaluating the compound's efficacy and safety profiles, aiming to understand its mechanism of action in biological systems.
  • Potential Side Effects: As with many pharmacologically active compounds, studying side effects and toxicological profiles is crucial for chemical safety and efficacy before they are considered for therapeutic use.

In conclusion, 1-(2-chlorophenyl)-N-methyl-N-sec-butyl-isoquinoline-3-carboxamide stands as a prime example of the intricate relationship between chemical structure and biological activity, making it a subject of interest for both chemists and pharmacologists alike.

Synonyms
PK 11195
85532-75-8
PK11195
PK-11195
1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
RP 52028
UNII-YNF83VN1RL
BRN 4264456
DTXSID7041097
CHEBI:73290
N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide
YNF83VN1RL
85340-56-3
DTXCID5021097
N-sec-butyl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide
3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-
RP-52028
PK11195,(R)-(-)-
N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide
N-(sec-Butyl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide
(R)-PK11195
N-METHYL-N-(1-METHYLPROPYL)-1-(2-CHLOROPHENYL)ISOQUINOLINE-3-CARBOXAMIDE
SMR000058427
SR-01000076240
205934-46-9
Biomol-NT_000287
(3H)PK11195
(13C)PK11195
C21H21ClN2O
Lopac0_000198
MLS000028483
MLS006010699
CHEMBL15313
SCHEMBL117124
BPBio1_001278
CHEMBL481537
GTPL8703
BDBM22032
HMS2234C05
HMS3260H17
HMS3266H15
HMS3372J02
HMS3411O10
HMS3675O10
HMS3870J13
EX-A2448
FIA93446
Tox21_300620
Tox21_500198
1-(2-chlorophenyl)-N-methyl-N-(sec-butyl)isoquinoline-3-carboxamide
HB0922
MFCD00069334
PDSP1_000637
PDSP2_000632
AKOS024458600
CCG-204293
LP00198
SDCCGSBI-0050186.P002
NCGC00015205-03
NCGC00015205-04
NCGC00015205-05
NCGC00015205-06
NCGC00015205-07
NCGC00015205-08
NCGC00015205-14
NCGC00024720-02
NCGC00024720-03
NCGC00024720-04
NCGC00254354-01
NCGC00260883-01
[3H]PK 11195
BM166506
DA-66759
HY-19567
MS-25479
CAS-85532-75-8
CS-0015789
EU-0100198
NS00015611
PK-11195; RP-52028
C 0424
E98630
1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)
Q7119490
SR-01000076240-1
SR-01000076240-3
BRD-A41451487-001-01-3
BRD-A41451487-001-04-7
BRD-A41451487-001-11-2
1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic acid sec-butyl-methyl-amide
N-Methyl-N-(1-methylpropyl)-1-(2-chlorophenyl)isoquinoline-3-carboxamide;RP 52028