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Clotrimazole

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Identification
Molecular formula
C22H17ClN2
CAS number
23593-75-1
IUPAC name
1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
State
State

At room temperature, clotrimazole is a solid powder. It is not extremely volatile, owing to its higher molecular mass and solid state, which contribute to its stable presence in powder form at ambient conditions.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.00
Boiling point (Celsius)
575.40
Boiling point (Kelvin)
848.60
General information
Molecular weight
344.84g/mol
Molar mass
344.8440g/mol
Density
1.2320g/cm3
Appearence

Clotrimazole typically appears as a white or pale cream-colored crystalline powder. It is usually odorless and has a bitter taste.

Comment on solubility

Solubility of 1-[(2-chlorophenyl)-diphenyl-methyl]imidazole (C22H17ClN2)

The solubility of 1-[(2-chlorophenyl)-diphenyl-methyl]imidazole is an important characteristic that can influence its application and usage in various chemical processes. This compound, due to its complex structure featuring both aromatic systems and a halogen, demonstrates unique solubility traits:

  • Solvent Dependence: The solubility of this imidazole derivative is largely dependent on the solvent used. It is expected to dissolve well in organic solvents, such as acetone or ethanol, due to its non-polar characteristics from the aromatic rings.
  • Water Solubility: Given its hydrophobic nature, it is anticipated that 1-[(2-chlorophenyl)-diphenyl-methyl]imidazole has limited solubility in water. Hydrophobicity often results in poor water solubility for compounds with high molecular weights and extensive aromatic character.
  • pH Effect: The solubility might change with varying pH levels, especially if any ionizable functional groups are present in related derivatives. However, the specific pH response of this compound requires further investigation.
  • Temperature Influence: As with many organic compounds, an increase in temperature can lead to improved solubility, making it crucial to consider thermal conditions when dissolving this compound.

In summary, the solubility profile of 1-[(2-chlorophenyl)-diphenyl-methyl]imidazole highlights the importance of solvent choice, temperature, and potential pH influences. As we explore the practical applications of this compound, understanding its solubility will be pivotal in its effective utilization in various chemical environments.

Interesting facts

Interesting Facts About 1-[(2-Chlorophenyl)-diphenyl-methyl]imidazole

1-[(2-chlorophenyl)-diphenyl-methyl]imidazole is a fascinating compound that showcases both synthetic and biological significance. Here are some noteworthy points about this compound:

  • Structure and Composition: This compound is an imidazole derivative, featuring an imidazole ring that is essential in many biological systems and pharmaceuticals. Its structure can also exhibit diverse interactions due to the presence of halogen and aromatic groups.
  • Pharmaceutical Relevance: Compounds containing imidazole rings are often found in a variety of medicinal applications, including antifungal agents, antihistamines, and other therapeutic drugs. The chlorophenyl group can contribute to the biological activity of the compound, making it a point of interest in drug discovery.
  • Mechanisms of Action: The unique structure of 1-[(2-chlorophenyl)-diphenyl-methyl]imidazole allows it to interact with specific enzymes or receptors, highlighting the importance of structural biology in understanding how modifications can enhance efficacy and selectivity in pharmaceutical agents.
  • Synthetic Pathways: The synthesis of imidazole derivatives can involve various methods, including multi-step reactions. This compound serves as an example of how chemists can derive complex molecules from simpler precursors, making it a useful model in organic chemistry education.
  • Research Potential: Current research may explore the compound's potential for novel applications in drug development, although further studies would be required to fully understand its properties and effects.

In summary, 1-[(2-chlorophenyl)-diphenyl-methyl]imidazole not only represents a unique chemical structure but also embodies the intricate connection between chemistry and biology. Continuous exploration of such compounds may lead to significant advancements in medicine and synthetic chemistry.

Synonyms
clotrimazole
23593-75-1
Lotrimin
Canesten
Mycelex
Clotrimazol
Mycosporin
Empecid
Mykosporin
Gyne lotrimin
Chlotrimazole
Trimysten
Gyne-Lotrimin
Mycelex G
Rimazole
Gynix
Mono-baycuten
Mycelex Troches
1-(o-Chlorotrityl)imidazole
Pedisafe
Mycelex 7
Tibatin
Lotrimin AF Cream
Lotrimin Af
Trivagizole 3
Desamix F
Mycelex-G
1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole
Mycelex OTC
Clotrimazolum
Gyne-Lotrimin 3
Canestine
Monobaycuten
Mycelex-7
Canifug
(Chlorotrityl)imidazole
Fem Care
Mycofug
BAY 5097
BAY b 5097
Mycelex-7 Combination Pack
Canestene
Clomatin
Cutistad
Lotrimax
Lotrimin AF Jock-Itch Cream
Stiemazol
Esparol
Mycelax
Nalbix
Gino-Lotremine
Gyne-Lotrimin Combination Pack
Pan-Fungex
1-(o-Chloro-alpha,alpha-diphenylbenzyl)imidazole
Gyne-Lotrimin 3 Combination Pack
Bay-B 5097
clotrimeizol
Trivagizole
Jidesheng
1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole
1-(o-Chlorophenyldiphenylmethyl)imidazole
(2-Chlorophenyl)diphenyl-1-imidazolylmethane
NSC 257473
1H-Imidazole, 1-[(2-chlorophenyl)diphenylmethyl]-
Diphenyl(2-chlorophenyl)(1-imidazolyl)methane
Diphenyl-(2-chlorophenyl)-1-imidazolylmethane
FB 5097
Lotrimin (TN)
1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole
Mycelex (TN)
Clotrimazol [INN-Spanish]
Clotrimazolum [INN-Latin]
DRG-0072
chlortrimazole
1-[(2-chlorophenyl)-diphenylmethyl]imidazole
GNF-Pf-3499
CCRIS 6245
B 5097
HSDB 3266
Bis-phenyl-(2-chlorophenyl)(1-imidazoyl)methane
1H-Imidazole, 1-((2-chlorophenyl)diphenylmethyl)-
Mycelex: MycosporinRimazole
Methane, bis-phenyl-(2-chlorophenyl)-1-imidazolyl-
EINECS 245-764-8
Bay b 9057
MFCD00057220
NSC257473
1-(2-chlorotrityl)imidazole
Bisphenyl-(2-chlorphenyl)-1-imidazolyl-methan
Prestwick_120
NSC-257473
UNII-G07GZ97H65
BRN 0622318
CHEBI:3764
1-[(2-chlorophenyl)(diphenyl)methyl]-1H-imidazole
DTXSID7029871
G07GZ97H65
1-((o-Chloro-phenyl)diphenylmethyl)imidazole
BAY-5097
Bis-fenil-(2-clorofenil)-1-imidazolil-metano
Lopac-C-6019
SVT-15652
CHEMBL104
MLS000028502
DTXCID009871
Klotrimazole
1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
5-23-04-00291 (Beilstein Handbook Reference)
Imidazole, 1-(o-chloro-alpha,alpha-diphenylbenzyl)-
1-(o-Chloro-.alpha.,.alpha.-diphenylbenzyl)imidazole
LOTRISONE COMPONENT CLOTRIMAZOLE
Clotrimazole [USAN:USP:INN:BAN:JAN]
NCGC00015251-02
Clotrimaderm
SMR000058306
FemCare
Lotrimin Lotion
Canesten Cream
CAS-23593-75-1
Clotrimazole 100 microg/mL in Acetonitrile
Lotrimin Cream
Mycelex Cream
Myclo Cream
Myclo-Gyne
Clotrimazol (INN-Spanish)
Clotrimazolum (INN-Latin)
Neo-Zol Cream
Bis-phenyl-(2-chlorophenyl)-1-imidazoyl)methane
Mycelex Twin Pack
CLOTRIMAZOLE (MART.)
CLOTRIMAZOLE [MART.]
Lotrimin AF Lotion
CLOTRIMAZOLE (USP-RS)
CLOTRIMAZOLE [USP-RS]
CLOTRIMAZOLE (EP IMPURITY)
CLOTRIMAZOLE [EP IMPURITY]
CLOTRIMAZOLE (EP MONOGRAPH)
CLOTRIMAZOLE (USP IMPURITY)
CLOTRIMAZOLE [EP MONOGRAPH]
CLOTRIMAZOLE [USP IMPURITY]
Canesten 1-Day Therapy
Canesten 3-Day Therapy
Canesten 6-Day Therapy
CLOTRIMAZOLE (USP MONOGRAPH)
CLOTRIMAZOLE [USP MONOGRAPH]
Clotrimazole (USAN:USP:INN:BAN:JAN)
Canesten 1-Day Cream Combi-Pak
Canesten Combi-Pak 1-Day Therapy
Canesten Combi-Pak 3-Day Therapy
SR-01000075771
1-((2-chlorophenyl)(diphenyl)methyl)-1H-imidazole
clortrimazole
clotrimazolo
Coltrimazole
Alevazol
Femmesil
Footlogix
Fortinia
Lakesia
Pedesil
Ringworm
Otomax
SilkaRingworm
UpandUp
HEBAntifungal
Mycelex Troche
Ringworm Cream
Clotrima Top
Fungistat Max
KrogerJock Itch
TM-Clotrimazole
Cura Hongo
TopCareAntifungal
Athlete s Foot
Fortinia OF
Gyne-Lotrimin3
Micotrin AC
Clotrimazole 1%
CVS Clotrimazole
DermatinAntifungal
FungicureIntensive
Mycozyl AC
ringworm treatment
Votriza-AL
Equate Jock Itch
Rexall Jock Itch
Clotrimaderm Cream
Drs. Clotrimazole
Dynarex Antifungal
Fungazoil Advanced
Major Clotrimazole
WalgreensJock Itch
Anti-Fungal Cream
Clotrimazole,(S)
Publixathletic foot
UpandUpClotrimazole
meijerAthletes Foot
Shoprite Antifungal
Athlete s FootAfac
Jock ItchAntifungal
Clotrimazole topical
Hua Tuo Xian Gao
Aspiera Anti-fungal
CAREONEClotrimazole
Cura HongoAntifungal
Cvshealth Antifungal
Zapotol Clotrimazole
meijerClotrimazole 3
PRO-EXAnti Fungal
CANESTENV
CLOT
ClotrimazoleJock Itch
Fungicure Liquid Gel
Oheal Ringworm Cream
Rexall Athletes Foot
Shopko Athletes Foot
Clotrimazole 1.0%
sunmarkClotrimazole 3
CAREALL Clotrimazole
lmnoop tinea treatment
PerfectHeal Antifungal
Topcare Athletes Foot
TopCareClotrimazole 3
Walgreens Clotrimazole
Bis-fenil-(2-clorofenil)-1-imidazolil-metano [Italian]
Bisphenyl-(2-chlorphenyl)-1-imidazolyl-methan [German]
Clotrimazoil Antifungal
Clotrimazole Antifungal
CVSAntifungal Ringworm
Foot Care Clotrimazole
lmnoop jock itch cream
Best ChoiceClotrimazole
CLOTRIMAZOL DUAL
JOCK-EZE
PedesilMaximum Strength
WinCo Foods Antifungal
Clotrimazole Cream 1%
KrogerATHLETES FOOT
Spectrum_001343
WalgreensClotrimazole 3
CPD000058306
PRO-EX
AKIN ANTI-FUNGAL
Clotrimazole (Canesten)
Clotrimazole (Standard)
Our FamilyAthletes Foot
Signature CareJock Itch
up and up athletes foot
ClotrimazoleAthletes Foot
Terrasil Tinea Treatment
Astonea Clotrimazole 1%
TerrasilMed ANTIFUNGAL
Good Sense Athletes Foot
Prestwick0_000267
Prestwick1_000267
Prestwick2_000267
Prestwick3_000267
Spectrum2_000128
Spectrum3_000359
Spectrum4_000295
Spectrum5_000781
CLOTRIMAZOLE [MI]
Healthy Accents Antifungal
lmnoop athletes foot Cream
Manuka Honey Eczema Cream
CLOTRIMAZOLE [INN]
CLOTRIMAZOLE [JAN]
SUNMARK CLOTRIMAZOLE
Dr Sheffield Athletes Foot
Quality Choice Clotrimazole
Rite Aidantifungal ringworm
Terrasil Ringworm Treatment
C 6019
CLOTRIMAZOLE [USAN]
CVS PharmacyClotrimazole 3
iShancare ringworm treatment
NCIMech_000609
Western FamilyAthletes Foot
cid_2812
SCHEMBL3850
Terrasil Tinea TreatmentMAX
Family Wellness Clotrimazole
Forticept Antifungal Cooling
CLOTRIMAZOLE [VANDF]
Lucky SuperSoftAthletes Foot
BIDD:PXR0036
ishancare jock itch treatment
Lopac0_000315
Quality Choice Athletes Foot
Terrasil Jock-Itch Treatment
Up and Up Jock Itch Relief
BSPBio_000114
BSPBio_002057
Clotrimazole 1%Athletes Foot
ishancare athletes foot Cream
KBioGR_000850
KBioSS_001823
Forticept Antifungal Foot Gel
MLS000758243
MLS001423972
BIDD:GT0450
Budpak Antifungal Clotrimazole
CLOTRIMAZOLE [WHO-DD]
DivK1c_000665
GOODSENSE ATHLETES FOOT
Meijer Clotrimazole Antifungal
SPECTRUM1500200
BAY b5097
BAYb 5097
Exchange Select Atheletes foot
Fastrin Anti-Fungal Skin Care
ishancare anti-fungal treatment
lmnoop serious antifungal cream
Smooth Gator Fungus Eliminator
SPBio_000176
SPBio_002333
Terrasil Anti-fungal Treatment
Terrasil Ringworm TreatmentMAX
Atopalm Clotrimazole Antifungal
AU KAH CHUEN ANTIFUNGAL
Clotrimazole Transdermal Liquid
Meijer Athletes Foot Cream AF
Veltrim 1% Dermatologic Cream
BPBio1_000126
Forticept Antifungal Foot Cream
GTPL2330
Leader Clotrimazole Anti-fungal
Jock ItchClotrimazole Antifungal
component of Otomax (Salt/Mix)
CVS ClotrimazoleMaximum Strength
Gyne-Lotrimin3 Combination Pack
Oheal Manuka Honey Eczema Cream
SIMPLY VITAL Antifungal Cream
Terrasil Jock-Itch TreatmentMAX
BDBM31774
Clotrimazole (JP18/USP/INN)
HMS502B07
KBio1_000665
KBio2_001823
KBio2_004391
KBio2_006959
KBio3_001277
Soundbody Clotrimazole Antifungal
Terrasil Rapid-clear Anti-fungal
Walgreens Clotrimazole Antifungal
A01AB18
Blossom Pharmaceuticals Antifungal
CLOTRIMAZOLE [GREEN BOOK]
Clotrimazole 1% Antifungal Cream
D01AC01
G01AF02
Imidazole, 1-(o-chloro-.alpha.,.alpha.-diphenylbenzyl)-
Athletes Foot AntifungalAntifungal
component of Lotrimax (Salt/Mix)
Good Neighbor PharmacyClotrimazole
Jock Itch Cream with Clotrimazole
NINDS_000665
Terrasil Anti-Fungal TreatmentMAX
Thera plus Antifungal Clotrimazole
CLOTRIMAZOLE [ORANGE BOOK]
Good Sense Athletes Footantifungal
HMS1568F16
HMS1920O21
HMS2051E11
HMS2091G10
HMS2095F16
HMS2235E20
HMS3260P12
HMS3369I03
HMS3393E11
HMS3655I09
HMS3712F16
Pharmakon1600-01500200
HUA TUO XIAN GAO ANTIFUNGAL
Imidazole,.alpha.-diphenylbenzyl)-
Rugby Clotrimazole Antifungal Cream
Terrasil Foot and Nail Anti-fungal
Aardora Anti-FungalMaximum Strength
BCP02150
Clotrimazole for peak identification
First Aid Research Antifungal .5oz
KXB07641
MSK21152
RUGBY ANTIFUNGAL CLOTRIMAZOLE
Tox21_110111
Tox21_300415
Tox21_500315
Astonea Clotrimazole 1%Athletes Foot
Athlete Foot Cream with Clotrimazole
CCG-35563
Good Neighbor PharmacyClotrimazole 3
HY-10882R
NSC756700
s1606
STK700023
AKOS005607024
Fungicure Manicure Pedicure Liquid Gel
Tox21_110111_1
1MED Clotrimazole 1% Antifungal Cream
Clotrimazole Topical Solution USP, 1%
CS-1926
CVS PharmacyITCH RELIEF ANTIFUNGAL
DB00257
FC20523
footlogix intensive carediabetic formula
LP00315
NC00035
NSC-756700
SB17418
SDCCGSBI-0050303.P005
Fungicure Manicure Pedicure Anti Fungal
IDI1_000665
LEADER ATHLETES FOOT CLOTRIMAZOLE
MRF-0000070
QTL1_000024
APTRIMAZOLE1.0% ANTIFUNGAL CREAM
Clotrimazole 1% Topical Antifungal Cream
First Aid Research Antifungal Cream 1oz
NCGC00015251-01
NCGC00015251-03
NCGC00015251-04
NCGC00015251-05
NCGC00015251-06
NCGC00015251-07
NCGC00015251-08
NCGC00015251-09
NCGC00015251-10
NCGC00015251-11
NCGC00015251-12
NCGC00015251-13
NCGC00015251-14
NCGC00015251-27
NCGC00093761-01
NCGC00093761-02
NCGC00093761-03
NCGC00093761-04
NCGC00093761-05
NCGC00093761-06
NCGC00254538-01
NCGC00261000-01
117829-71-7
1ST21152
AS-13816
CLOTRIMAZOLE COMPONENT OF LOTRISONE
HY-10882
OcculusSkin Hydrating Topical Foam CLO-1
SY051361
Terrasil Tinea Treatment Maximum Strength
SBI-0050303.P004
Terrasil Antifungal Cream Maximum Strength
DB-046195
1-[(2-Chlorophenyl)diphenylmethyl]imidazole
AB00051951
C2867
EU-0100315
NS00000282
SW196431-5
Terrasil JockItch Treatment Maximum Strength
Botanimedix TineaRX Antifungal Drying Emulsion
Terrasil Jock Itch Treatment Maximum Strength
C06922
D00282
Terrasil Athletes Foot AntiFungal Treatment Max
1-(.alpha.-(2-Chlorophenyl)benzhydryl)imidazole
1-[(2-chlorophenyl)-di(phenyl)methyl]imidazole
AB00051951-14
AB00051951_15
AB00051951_16
Clotrimazole, VETRANAL(TM), analytical standard
EN300-7409200
A816789
Q413546
Terrasil Foot and Nail Anti-FungalMaximum Strength
1H-Imidazole, 1-[(2-chlorophenyl)-diphenylmethyl]
SR-01000075771-1
SR-01000075771-6
SR-01000075771-8
1-[(2-Chloro-phenyl)-diphenyl-methyl]-1H-imidazole
BRD-K15916496-001-14-7
BRD-K15916496-001-26-1
BRD-K15916496-001-27-9
SR-01000075771-10
3ACDFDF8-38E3-4368-85D0-BDF8AE1E6591
Clotrimazole, British Pharmacopoeia (BP) Reference Standard
Clotrimazole, European Pharmacopoeia (EP) Reference Standard
OcculusSKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM
Clotrimazole, United States Pharmacopeia (USP) Reference Standard
1-[(2-Chlorophenyl)-diphenyl-methyl]-1H-imidazole;FB-5097;Bay B 5097
1-(o-Chlorotrityl)imidazole;1-(o-Chloro-alpha,alpha-diphenylbenzyl)imidazole
Clotrimazole for peak identification, European Pharmacopoeia (EP) Reference Standard
Clotrimazole, Pharmaceutical Secondary Standard; Certified Reference Material
245-764-8