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Chlorphenamine

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Identification
Molecular formula
C16H19ClNO
CAS number
113-92-8
IUPAC name
1-(2-chlorophenyl)-3-(dimethylamino)-1-phenyl-propan-1-ol
State
State

At room temperature, Chlorphenamine is a solid. It is primarily available in the form of tablets, but can also be found as an injectable and other formulations for medical use.

Melting point (Celsius)
130.00
Melting point (Kelvin)
403.15
Boiling point (Celsius)
387.80
Boiling point (Kelvin)
660.95
General information
Molecular weight
274.79g/mol
Molar mass
274.7880g/mol
Density
1.0815g/cm3
Appearence

Chlorphenamine is a white to off-white solid, typically in the form of a crystalline powder. It is commonly used in oral tablet or capsule formulations.

Comment on solubility

Solubility of 1-(2-chlorophenyl)-3-(dimethylamino)-1-phenyl-propan-1-ol

The compound 1-(2-chlorophenyl)-3-(dimethylamino)-1-phenyl-propan-1-ol, with the chemical formula C16H19ClNO, exhibits intriguing solubility characteristics influenced by its molecular structure.

Here are some key considerations regarding its solubility:

  • Polar vs. Nonpolar Solvents: This compound contains both hydrophobic aromatic rings and a hydrophilic alcohol group. As a result, it tends to be soluble in a variety of solvents.
  • Water Solubility: The presence of the alcohol group may suggest some degree of solubility in water, although the chlorophenyl substituent may hinder this to an extent.
  • Organic Solvents: It is likely more soluble in organic solvents such as ethanol, dichloromethane, or acetone due to its nonpolar characteristics.

As a general rule, compounds with similar polarity tend to dissolve well in each other, which is often summarized by the phrase "like dissolves like." Thus, one might observe:

  1. High solubility in nonpolar solvents.
  2. Moderate solubility in polar organic solvents.
  3. Limited solubility in water.

It is essential to consider that temperature, pH, and the presence of other ions can further influence solubility. Ultimately, understanding the solubility of this compound is crucial for its various applications in pharmaceuticals and chemical synthesis.

Interesting facts

Interesting Facts about 1-(2-chlorophenyl)-3-(dimethylamino)-1-phenyl-propan-1-ol

This intriguing compound, known for its complex structure, has garnered attention in the field of chemistry due to its diverse applications and properties. Here are some captivating points about this compound:

  • Pharmaceutical Relevance: The compound is often studied for its potential applications in medicinal chemistry. Its structure can be adapted to create novel therapeutic agents.
  • Chirality: The presence of several chiral centers within its molecular framework leads to interesting stereochemistry, affecting how the compound interacts with biological systems.
  • Reactivity: The chlorophenyl group enhances reactivity, making it a valuable intermediate in organic synthesis. Chemists utilize this property to develop derivatives that could possess improved pharmacological effects.
  • Dimethylamino Group: The dimethylamino moiety is known for imparting basic properties, which expands the chemical reactivity and enables it to serve as a signaling molecule in various reactions.
  • Research Potential: Due to its multifaceted nature, the compound is often a subject of research in fields like medicinal chemistry, organic synthesis, and material science.

As noted by many researchers in the field, the ability to modify such compounds can lead to significant advancements in drug development. As one scientist put it, "The synthesis of compounds like 1-(2-chlorophenyl)-3-(dimethylamino)-1-phenyl-propan-1-ol opens doors to understanding not just chemistry but the intricate dance between structure and function in biology."

This compound exemplifies how chemical intricacies can lead to vast opportunities in research and application, making it a fascinating subject for both chemists and pharmaceutical scientists alike.

Synonyms
Clofedanol
CHLOPHEDIANOL
791-35-5
Chlofedanol
Tussistop
Dencyl
Clophedianol base
Clofedano
Calmotusin
Ulo base
Antitussin
Clofedanolum
Clofedianolo
Clofedianolo [Italian]
SL 501 base
Clofedanolum [INN-Latin]
Abehol
1-(2-chlorophenyl)-3-(dimethylamino)-1-phenylpropan-1-ol
Clofedanol [INN:BAN]
1-Phenyl-1-(o-chlorophenyl)-3-dimethylaminopropanol
Antitussin (TN)
alpha-(Dimethylaminoethyl)-o-chlorobenzhydrol
Clofedanol (INN)
2-Chloro-alpha-(2-(dimethylamino)ethyl)benzhydrol
NSC 113595
EINECS 212-340-9
NSC-113595
BRN 2813922
DTXSID4022789
42C50P12AP
2-Cloro-alpha-(2-dimetilaminoetil)-benzidrolo [Italian]
CLOFEDANOL [INN]
1-(2-Chlorophenyl)-3-(dimethylamino)-1-phenyl-1-propanol
2-Cloro-alpha-(2-dimetilaminoetil)-benzidrolo
CHLOPHEDIANOL [MI]
CLOFEDANOL [WHO-DD]
1-(2-Chlorophenyl)-1-phenyl-3-dimethylaminopropanol
Benzenemethanol, 2-chloro-.alpha.-[2-(dimethylamino)ethyl]-.alpha.-phenyl-
CHLOPHEDIANOL [VANDF]
MLS002706537
DTXCID602789
CHEBI:135207
.alpha.-(Dimethylaminoethyl)-o-chlorobenzhydrol
2-Chloro-.alpha.-(2-dimethylaminoethyl)benzhydrol
Benzenemethanol, 2-chloro-alpha-(2-(dimethylamino)ethyl)-alpha-phenyl-
Benzhydrol, 2-chloro-alpha-(2-(dimethylamino)ethyl)-
baltix
(+/-)-Chlophedianol
Clofedanolum (INN-Latin)
Calmotusin; Chlophedianol; Clofedanol; NSC 113595
Benzhydrol, 2-chloro-.alpha.-[2-(dimethylamino)ethyl]-
1-O-CHLOROPHENYL-1-PHENYL-3-DIMETHYLAMINO-1-PROPANOL
Benzenemethanol, 2-chloro-alpha-(2-(dimethylamino)ethyl)-alpha-phenyl- (9CI)
Benzhydrol, 2-chloro-.alpha.-(2-(dimethylamino)ethyl)-
clofedanolo
UNII-42C50P12AP
2-Chloro-alpha-(2-dimethylaminoethyl)benzhydrol
NCGC00181096-01
SCHEMBL29734
GTPL7324
CHEMBL1201313
R05DB10
HY-A0161
Tox21_112712
EX-A10959
NSC113595
AKOS015962243
Benzenemethanol, 2-chloro-alpha-(2-(dimethylamino)ethyl)-alpha-phenyl-(9CI)
DB04837
511-13-7 pound not791-35-5
AC-16003
CAS-791-35-5
SMR001573941
NS00006805
D07721
SBI-0654214.0001
2-Cloro-.alpha.-(2-dimetilaminoetil)-benzidrolo
EN300-18567728
Q2964078
BRD-A15687940-001-05-6
(S)-1-(2-chlorophenyl)-3-(dimethylamino)-1-phenylpropan-1-ol
1-(2-Chlorophenyl)-3-(dimethylamino)-1-phenyl-1-propanol #
DL-1-Phenyl-1-(2-chlor-phenyl)-3-dimethylamino-propanol-(1)
BENZENEMETHANOL, 2-CHLORO-.ALPHA.-(2-(DIMETHYLAMINO)ETHYL)- .ALPHA.-PHENYL
BENZENEMETHANOL, 2-CHLORO-.ALPHA.-(2-(DIMETHYLAMINO)ETHYL)-.ALPHA.-PHENYL
BENZENEMETHANOL, 2-CHLORO-ALPHA-(2-(DIMETHYLAMINO)ETHYL)-ALPHA-PHENYL