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Clotrimazole

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Identification
Molecular formula
C22H17Cl3N2S
CAS number
23593-75-1
IUPAC name
1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole
State
State

Clotrimazole is typically found as a solid at room temperature.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.15
Boiling point (Celsius)
525.20
Boiling point (Kelvin)
798.35
General information
Molecular weight
344.84g/mol
Molar mass
344.8440g/mol
Density
1.2290g/cm3
Appearence

Clotrimazole is a white to pale yellow crystalline powder. It is practically insoluble in water but soluble in chloroform and ethanol.

Comment on solubility

Solubility of 1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole

The solubility of 1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole (C22H17Cl3N2S) is an intriguing aspect to explore due to its complex structure and the presence of multiple functional groups. Here are some key considerations regarding its solubility:

  • Polarity: The compound contains a mix of polar and non-polar groups, which can influence its solubility in various solvents.
  • Solvent Compatibility: It is likely to exhibit moderate solubility in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), while having limited solubility in water due to its relatively large hydrophobic regions.
  • Effect of Substituents: The presence of chloride substituents may enhance interactions with certain solvents, potentially increasing solubility in specific conditions.
  • Temperature Dependence: Like many organic compounds, solubility may also increase with temperature, making it essential to consider thermal conditions in applications.

In conclusion, the solubility of this compound is affected by its complex structure. Understanding these factors is vital for its application in various fields, as solubility governs the compound's accessibility and efficacy in reactions or therapeutic uses. As with many chemical compounds, conducting solubility tests under controlled conditions may yield specific data that can aid in practical applications.

Interesting facts

Interesting Facts about 1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole

The compound 1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole presents a fascinating study in chemical diversity and potential applications:

  • Structure and Function: This compound features a complex imidazole ring, which is known for its ability to interact with biological systems. The imidazole structure is pivotal in many natural and synthetic products, influencing pharmacological activities.

  • Substituent Influence: The presence of multiple chloro groups and a methylsulfanyl moiety adds significant stability and potentially alters the compound's reactivity. These substituents could contribute to enhanced lipophilicity, affecting the bioavailability of the molecule in therapeutic contexts.

  • Biological Significance: Compounds containing imidazole derivatives are often investigated for their biological activity, including antimicrobial and antifungal properties. Their interactions with enzymes and receptors can lead to novel pharmacological agents.

  • Potential Applications: Due to its structure, this compound could be explored for use in pharmaceuticals targeting various diseases, or as a building block in complex organic synthesis, showcasing the versatility of imidazole derivatives.

  • Research and Innovation: As research in medicinal chemistry continues to advance, such compounds are prime candidates for design modifications aimed at improving efficacy and reducing toxicity.

In summary, 1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole embodies the intricate relationship between structure and function in chemical compounds. With ongoing studies, its applications could significantly impact the field of biomedical research and pharmaceuticals.

Synonyms
sulconazole
61318-90-9
Sulconazol
Sulconazolum
1-(2-((4-Chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
Sulconazolum [INN-Latin]
Sulconazol [INN-Spanish]
(+/-)-Sulconazole
1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole
UNII-5D9HAA5Q5S
5D9HAA5Q5S
DTXSID8044129
CHEBI:77776
Sulconazole (INN)
1-{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
(+-)-1-(2,4-Dichlor-beta-((4-chlorbenzyl)thio)phenethyl)imidazol
SULCONAZOLE [INN]
(+-)-1-(2,4-dichloro-beta-((p-chlorobenzyl)thio)phenethyl)imidazole
Sulconazol (INN-Spanish)
Sulconazolum (INN-Latin)
1-[2-(4-Chloro-benzylsulfanyl)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1H-Imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-, (+-)-
C18H15Cl3N2S
Sulconazole [INN:BAN]
1H-IMIDAZOLE, 1-(2-(((4-CHLOROPHENYL)METHYL)THIO)-2-(2,4-DICHLOROPHENYL)ETHYL)-
1H-IMIDAZOLE, 1-(2-(((4-CHLOROPHENYL)METHYL)THIO)-2-(2,4-DICHLOROPHENYL)ETHYL)-, (+/-)-
()-Sulconazole
1H-Imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-
Spectrum_001416
SULCONAZOLE [MI]
1-(beta-(4''-chlorobenzylthio)-2'4'-dichlorophenethyl)imidazole
Prestwick0_000810
Prestwick1_000810
Prestwick2_000810
Prestwick3_000810
Spectrum2_001422
Spectrum3_001457
Spectrum4_000436
Spectrum5_001155
SULCONAZOLE [VANDF]
CHEMBL1221
SCHEMBL34761
BSPBio_000679
BSPBio_002953
KBioGR_000792
KBioSS_001896
SULCONAZOLE [WHO-DD]
cid_65495
DivK1c_000220
SPBio_001524
SPBio_002600
BPBio1_000747
CHEBI:9325
DTXCID6024129
BDBM31770
HY-B1460B
KBio1_000220
KBio2_001896
KBio2_004464
KBio2_007032
KBio3_002453
D01AC09
AFNXATANNDIXLG-UHFFFAOYSA-N
NINDS_000220
AKOS015961204
DB06820
IDI1_000220
NCGC00018250-02
AC-13116
SBI-0051660.P002
DB-053840
7106B
AB00053607
CS-0013811
C08076
D08535
G66877
AB00053607_16
AB00053607_17
EN300-18563874
Q2392530
BRD-A70649075-008-05-0
BRD-A70649075-008-17-5
BRD-A70649075-008-29-0
BRD-A70649075-008-30-8
1-[2,4-dichloro-beta-(4-chlorobenzylthio)phenethyl]imidazole
(+-)-1-(2,4-dichloro-beta-((4-chlorobenzyl)thio)phenethyl)imidazole
1-(2-(4-chlorobenzylthio)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
1-(2-(((4-CHLOROPHENYL)METHYL)THIO)-2-(2,4-DICHLOROPHENYL)ETHYL)-1H-IMIDAZOLE
1-(2-{[(4-chlorophenyl)methyl]sulfanyl}-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
1H-Imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-(9CI)
rac-1-(2-((4-chlorobenzyl)sulfanyl)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole