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Clotrimazole

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Identification
Molecular formula
C22H17Cl3N2O
CAS number
23593-75-1
IUPAC name
1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
State
State

Clotrimazole is solid at room temperature.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.15
Boiling point (Celsius)
561.60
Boiling point (Kelvin)
834.80
General information
Molecular weight
344.84g/mol
Molar mass
344.8370g/mol
Density
1.2440g/cm3
Appearence

Clotrimazole appears as a white to pale yellow crystalline powder.

Comment on solubility

Solubility of 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole

The solubility of the compound 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole (C22H17Cl3N2O) can be understood through several key factors:

  • Polarity: The presence of chlorine atoms enhances the polarity of the molecule, potentially affecting its interactions with solvents.
  • Functional Groups: The imidazole ring and methoxy group can exhibit varying solubility behavior in polar and nonpolar solvents.
  • Crystallinity: Crystalline compounds generally exhibit lower solubility compared to amorphous forms, which can dissolve more readily.
  • Temperature Effects: Increased temperature often enhances solubility, allowing more compound to dissolve in a given solvent.

In general, compounds that contain both polar and nonpolar regions often show variable solubility depending on the solvent used. For instance, this compound may demonstrate better solubility in polar aprotic solvents, while having limited solubility in nonpolar solvents. It is crucial to test solubility under various conditions to determine the most effective solvent system for this compound.

As stated in solubility principles, “like dissolves like,” emphasizing the importance of understanding the interaction between the solute (this compound) and the solvent. Therefore, exploring the solubility of this compound can provide insights into its potential applications and behavior in various chemical environments.

Interesting facts

Interesting Facts about 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole

This compound is notable for its structure and activity, making it a subject of interest in both medicinal chemistry and pharmacology. Here are some fascinating aspects of this chemical:

  • Diverse Applications: Compounds like this one, which feature imidazole rings, are often studied for their antimicrobial and antifungal properties. They may play significant roles in the development of new therapeutic agents.
  • Chlorophenyl Groups: The presence of chlorophenyl groups in its structure can enhance the lipophilicity of the compound, which may affect its ability to penetrate biological membranes. This is crucial for its potential efficacy as a drug.
  • Intriguing Mechanism: The imidazole moiety is well-regarded for its biological activity. It can interact with biological systems in unique ways, potentially acting on multiple targets within the body.
  • Research Impact: This compound is part of ongoing research endeavors, particularly in the fields of cancer therapy and infectious disease treatment, drawing attention from various scientific communities.
  • Structure-Activity Relationship (SAR): Studies focusing on its structural elements offer insights into the compound's pharmacological effects, highlighting the significance of specific substituents on biological activity.

In conclusion, 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole is not just a simple chemical entity but a complex compound with numerous implications in science and medicine. As researchers continue to explore its properties, we may uncover even more exciting possibilities for its use in therapeutic applications.

Synonyms
econazole
27220-47-9
Ecostatin
Econazolum
Econazol
(+-)-Econazole
1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
Spectazole
UNII-6Z1Y2V4A7M
NSC 187789
NSC-187789
6Z1Y2V4A7M
CCRIS 9032
Econazol [INN-Spanish]
EINECS 248-341-6
BRN 0964150
(+/-)-ECONAZOLE
1-(2-((4-Chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-
DTXSID2029872
CHEBI:82873
SQ 13050
1-{2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
NSC187789
(+/-)-Econazol
1-(2,4-Dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole
Econazol (INN-Spanish)
1-{2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
ECONAZOLE (MART.)
ECONAZOLE [MART.]
ECONAZOLE (EP MONOGRAPH)
ECONAZOLE [EP MONOGRAPH]
Ekonazole
Imidazole, 1,2,4-dichloro-beta-(p-chlorobenzyl)oxyphenethyl-
1-(2,4-Dichloro-.beta.-((p-chlorobenzyl)oxy)phenethyl)imidazole
1-[2,4-Dichloro-.beta.-[(p-chlorobenzyl)oxy]phenethyl]imidazole
R-14827
1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
Imidazole, 1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)-
1H-Imidazole, 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-
Econazole [USAN]
MICONAZOLE IMPURITY B (EP IMPURITY)
MICONAZOLE IMPURITY B [EP IMPURITY]
Econazole (USAN/INN)
NCGC00018258-03
econazolo
Econazole [USAN:INN:BAN]
rac-econazole
1-(2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
1-[2-(4-Chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
(RS)-econazole
()-Econazol
MFCD00800993
Econazole (Standard)
Spectrum_001223
ECONAZOLE [INN]
ECONAZOLE [MI]
(.+/-.)-Econazole
Prestwick0_000304
Prestwick1_000304
Prestwick2_000304
Prestwick3_000304
Spectrum2_001439
Spectrum3_001467
Spectrum4_000446
Spectrum5_001033
ECONAZOLE [VANDF]
CHEMBL808
ECONAZOLE [WHO-DD]
SCHEMBL34498
BSPBio_000268
BSPBio_002993
KBioGR_000832
KBioSS_001703
cid_68589
DivK1c_000113
SPBio_001578
SPBio_002487
BPBio1_000296
CHEBI:4754
DTXCID409872
GTPL2446
BDBM31773
HY-B0885R
KBio1_000113
KBio2_001703
KBio2_004271
KBio2_006839
KBio3_002493
D01AC03
G01AF05
NINDS_000113
HY-B0885
s5492
STL483402
AKOS015889868
1H-Imidazole,4-dichlorophenyl)ethyl]-
CCG-268426
DB01127
FC33390
IDI1_000113
NCGC00018258-02
NCGC00018258-05
NCGC00018258-06
NCGC00018258-07
NCGC00018258-09
AS-13862
MFCD00058160 (.HNO3)
NCI60_001564
NCI60_001947
SBI-0051682.P002
DB-047186
AB00053611
NS00005601
C08068
D03936
F14858
AB00053611-20
AB00053611_21
AB00053611_22
EN300-7371061
68797-31-9 (.HNO3)
AA-504/31991001
Q417141
MICONAZOLE NITRATE IMPURITY B [EP IMPURITY]
BRD-A51820102-008-05-7
BRD-A51820102-008-16-4
BRD-A51820102-008-27-1
BRD-A51820102-008-28-9
Imidazole,4-dichloro-.beta.-[(p-chlorobenzyl)oxy]phenethyl]-
1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole
1-[2-(4-chloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
4-Chlorobenzyl 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl ether
Imidazole, 1-(2,4-dichloro-.beta.-((p-chlorobenzyl)oxy)phenethyl)-
rac-1-(2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
1-[(2RS)-2-[(4-Chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
248-341-6