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Metoprolol

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Identification
Molecular formula
C15H25NO3
CAS number
37350-58-6
IUPAC name
1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol
State
State

At room temperature, metoprolol is in a solid state.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.15
Boiling point (Celsius)
380.00
Boiling point (Kelvin)
653.15
General information
Molecular weight
267.36g/mol
Molar mass
267.3640g/mol
Density
1.6330g/cm3
Appearence

Metoprolol is typically seen as a white or off-white powder. It is crystalline in nature and does not have any significant odor.

Comment on solubility

Solubility of 1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol

The solubility of the compound designated as 1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol (C15H25NO3) can be characterized by several factors related to its molecular structure.

Factors Influencing Solubility

  • Polarity: The presence of hydroxyl (–OH) groups and methoxy (–OCH3) groups in the structure enhances the compound's ability to engage in hydrogen bonding.
  • Hydrophobic Character: The 3-methylphenoxy group contributes to the hydrophobic nature, potentially reducing solubility in polar solvents.
  • Solvent Choice: This compound is likely to be soluble in organic solvents and moderately soluble in alcohols, demonstrating the impact of solvent interactions.

As a general insight, compounds with significant hydrophobic regions can demonstrate lower solubility in water, while those with multiple polar functional groups are often more soluble in aqueous solutions. For 1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol, solubility can be maximized in environments where the solvent's polarity aligns with the polar characteristics of the molecule.

It is essential to consider the overall environment as many drugs and compounds behave differently when salts or alterations in their chemical structure are introduced.

Interesting facts

Interesting Facts about 1-[2-(3,4-Dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol

This compound is a notable member of the class of amines, which are characterized by the presence of one or more amine groups. It showcases fascinating characteristics and potential applications in various fields. Here are some compelling insights:

  • Pharmaceutical Potential: Many compounds that contain amine groups, like this one, are often investigated for their therapeutic effects. They can act as intermediates in developing drugs for various conditions, particularly those related to neurotransmitter activity.
  • Structural Complexity: The molecular structure includes multiple aromatic rings and functional groups, which can greatly influence its pharmacokinetic properties. Understanding this complexity is vital for predicting how the compound will behave in biological systems.
  • Chiral Centers: This compound features chiral centers, making it a candidate for stereochemical studies. The different enantiomers (mirror images) of a chiral compound can exhibit different biological activities, which is crucial in drug design.
  • Research Applications: Such compounds can serve as probes in studying biochemical pathways. They can help in the elucidation of mechanisms in neurotransmission due to the involvement of phenyl and methoxy functional groups.
  • Historical Context: Compounds of this nature have been developed over the years, with researchers often modifying their structures to improve efficacy and reduce side effects. This compound exemplifies the ongoing quest for improved pharmacological agents.

In summary, the study of 1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol goes beyond just its chemical structure; it taps into a broader narrative of medicinal chemistry and drug development. As the field continues to evolve, compounds like this will likely play a key role in the next generation of treatments.

Synonyms
Bevantolol
59170-23-9
Bevantololum
Bevantololum [INN-Latin]
Bevantolol [INN:BAN]
1-(3,4-Dimethoxyphenethylamino)-3-(m-tolyloxy)-2-propanol
(+-)-bevantolol
UNII-34ZXW6ZV21
1-((2-(3,4-Dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-2-propanol
NSC-132348
BRN 2769444
34ZXW6ZV21
1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol
CHEBI:238698
BEVANTOLOL [MI]
BEVANTOLOL [INN]
BEVANTOLOL [WHO-DD]
1-(3,4-dimethoxyphenethylamino)-3-m-tolyloxy-propan-2-ol
DTXSID70860597
1-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-3-m-tolyloxy-propan-2-ol
1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(3-methylphenoxy)propan-2-ol
NSC 132348
Bevantololum (INN-Latin)
2-Propanol, 1-((2-(3,4-dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-
(+/-)-1-((3,4-DIMETHOXYPHENETHYL)AMINO)-3-(M-TOLYLOXY)-2-PROPANOL
2-PROPANOL, 1-((2-(3,4-DIMETHOXYPHENYL)ETHYL)AMINO)-3-(3-METHYLPHENOXY)-, (+/-)-
1-((3,4-Dimethoxyphenethyl)amino)-3-(m-tolyloxy)propan-2-ol
(+/-)-Bevantolol; DL-Bevantolol; NSC 132348
1-(2-(3,4-Dimethoxy-phenyl)-ethylamino)-3-m-tolyloxy-propan-2-ol
1-((2-(3,4-dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)propan-2-ol
(+/-)-bevantolol
SCHEMBL49721
MLS003876814
CHEMBL314010
C07AB06
DTXCID80197265
HXLAFSUPPDYFEO-UHFFFAOYSA-N
HMS3604B08
HY-A0249
NSC132348
AKOS016014301
DB01295
SMR002529477
()-Bevantolol; DL-Bevantolol; NSC 132348
EN300-741859
SBI-0653887.0001
L013370
Q1956953
BRD-A18233884-003-02-7
Z31382955
1-[[2-(3,4-dimethoxyphenyl) ethyl]amino]-3-(3-methyl-phenoxy)-2-propanol