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Clotrimazole

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Identification
Molecular formula
C22H17Cl2N2O
CAS number
23593-75-1
IUPAC name
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
State
State

At room temperature, clotrimazole is in the form of a solid crystalline powder.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.15
Boiling point (Celsius)
498.10
Boiling point (Kelvin)
771.25
General information
Molecular weight
344.31g/mol
Molar mass
344.6430g/mol
Density
1.3720g/cm3
Appearence

Clotrimazole appears as a white or pale yellow crystalline powder. It is almost odorless.

Comment on solubility

Solubility of 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole

This compound, with the chemical formula C22H17Cl2N2O, exhibits specific solubility characteristics that are of interest. Solubility is a critical property that influences the behavior and application of compounds in various chemical and pharmaceutical processes.

General Solubility Profile

The solubility of 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole can be summarized as follows:

  • Solvent Compatibility: This compound shows a tendency to dissolve in organic solvents, such as DMSO or ethanol, rather than in water.
  • Hydrophobic Nature: Due to the presence of multiple chlorine substituents and large aromatic groups, this compound is likely to be hydrophobic, making it less soluble in polar solvents.
  • Temperature Dependence: Like many organic compounds, solubility may increase with temperature, potentially aiding in its dissolution in selected solvents.

Implications of Solubility

The solubility of this compound holds significant implications for its:

  • Biological Activity: Compounds that are poorly soluble in water may present challenges in biological systems, affecting absorption and bioavailability.
  • Formulation Strategies: Understanding its solubility can guide the development of appropriate formulations, ensuring effective delivery in pharmaceuticals.

In conclusion, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole exhibits a unique solubility profile that is largely influenced by its molecular structure, underscoring the importance of solubility in various applications.

Interesting facts

Interesting Facts about 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole

1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole is a remarkable compound that has captivated the attention of chemists and pharmacologists alike. Here are some intriguing facts about this complex structure:

  • Pharmaceutical Relevance: This compound belongs to a class of imidazole derivatives that are often researched for their potential antifungal and antimicrobial properties. Scientists are particularly interested in how the dichlorophenyl groups may enhance activity against various pathogens.
  • Synthetic Origins: The synthesis of this compound showcases the art of organic chemistry, demonstrating how multiple reactive functional groups can be combined to create more complex molecules. It often involves the careful manipulation of both electrophilic and nucleophilic reactions.
  • Structure-Activity Relationship (SAR): The unique imidazole ring plays a critical role in the biological activity of this compound. Understanding how changes to the dichlorophenyl groups affect its efficacy can help in the design of even more potent therapeutic agents.
  • Environmental Impact: Compounds with chlorine substitutions, such as in this case, raise questions about environmental persistence and biodegradability. Studying the environmental fate of such chemicals is essential in assessing their overall safety.
  • Multifunctionality: The presence of both an ether functional group and multiple chlorinated phenyl rings suggests potential for various interactions, making this compound a candidate for further research in multidisciplinary applications.

As we delve deeper into the study of compounds like 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole, we pave the way for innovative solutions in medicinal chemistry and other fields. The continual exploration of its properties is vital in unlocking potential future applications.

Synonyms
miconazole
22916-47-8
Monistat
Monistat IV
Daktarin IV
Miconazol
Miconazolo
Miconazolum
Minostate
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
MJR 1762
Miconazolum [INN-Latin]
Vusion
Monistat-Derm
Oravig
Florid(nitrate)
1-(2-((2,4-Dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
Miconazol [INN-Spanish]
NSC 170986
Brentan
R 18134
MFCD00216019
1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-
CCRIS 7924
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
UNII-7NNO0D7S5M
EINECS 245-324-5
7NNO0D7S5M
BRN 0965511
DTXSID6023319
R18134 nitrate
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-
CHEMBL91
Monistat (TN)
Miconazole nitrate salt
DTXCID803319
MCZ
Dactarin
CHEBI:82892
Miconazole [USP:INN:BAN:JAN]
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
Imidazole, 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)-
22916-47-8 (free)
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-
NSC170986
NSC-170986
Miconazolo [DCIT]
NCGC00016770-01
Micozole
Zimycan
Miconazol (INN-Spanish)
Miconazolum (INN-Latin)
imidazole, 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy) phenethyl)-
Femizol-M
Miconazole-7
MICONAZOLE (MART.)
MICONAZOLE [MART.]
Monazole 7
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1H-imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)-
MICONAZOLE (EP IMPURITY)
MICONAZOLE [EP IMPURITY]
C18H14Cl4N2O
MICONAZOLE (EP MONOGRAPH)
MICONAZOLE (USP IMPURITY)
MICONAZOLE [EP MONOGRAPH]
MICONAZOLE [USP IMPURITY]
Miconazole (USP:INN:BAN:JAN)
MICONAZOLE (USP MONOGRAPH)
MICONAZOLE [USP MONOGRAPH]
Aflorix(nitrate)
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-[(2,4-Dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
Albistat(nitrate)
Andergin(nitrate)
Conofite(nitrate)
(+/-)-1-(2,4-DICHLORO-B-((2,4-DICHLOROBENZYL)OXY)PHENETHYL)IMIDAZOLE
(+/-)-Miconazole nitrate salt
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
Monista (nitrate)
1H-IMIDAZOLE, 1-2-((2,4-DICHLOROPHENYL)-2-((2,4-DICHLOROPHENYL))METHOXY)ETHYL)-, (+/-)-
Micantin (nitrate)
(+-)-Miconazole
Novo-Miconazole Vaginal Ovules
Gyno-Daktar(nitrate)
Lotrimin AF(nitrate)
Epi-Monistat(nitrate)
Monistat 7 Vaginal Suppositories
Zimybase
rac-miconazole
1-(2,4-Dichloro-beta-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole
SR-01000000271
1-(2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
(RS)-miconazole
1-(2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl)-1H-imidazole
1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-1h-imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
Prestwick_335
Oravig (TN)
Miconazole (Monistat)
Miconazole (Standard)
Spectrum_000965
MICONAZOLE [MI]
MICONAZOLE [INN]
MICONAZOLE [JAN]
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
MICONAZOLE [VANDF]
bmse000924
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
cid_4189
SCHEMBL2866
MICONAZOLE [WHO-DD]
Oprea1_091955
BSPBio_000253
BSPBio_002033
KBioGR_000581
KBioSS_001445
MLS002222203
DivK1c_000156
SPBio_000976
SPBio_002174
BPBio1_000279
CHEBI:6923
GTPL2449
Miconazole (JP17/USP/INN)
MICONAZOLE [ORANGE BOOK]
SCHEMBL13934598
BDBM31772
HY-B0454R
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
A01AB09
A07AC01
D01AC02
G01AF04
J02AB01
S02AA13
NINDS_000156
HMS1568M15
HMS2090B21
HMS2095M15
HMS2232B14
HMS3374J10
HMS3656E14
HMS3712M15
HY-B0454
MSK10020
Tox21_110601
DL-448
s2536
STK834405
1-(2,4-dichlorophenyl)-1-[(2,4-dichlorophenyl)methoxy]-2-imidazolylethane
AKOS001574474
AKOS016842489
CCG-220067
DB01110
DS-1881
FM30277
1H-Imidazole, 1-2-((2,4-dichlorophenyl)-2-((2,4-dichlorophenyl))methoxy)ethyl)-, (+-)-
IDI1_000156
NCGC00018294-02
NCGC00018294-04
NCGC00018294-06
NCGC00018294-08
NCI60_001353
NCI60_001380
SMR001307249
SY107559
SBI-0051448.P003
CAS-22916-47-8
DB-046018
AB00053500
NS00004552
SW196614-4
D00416
AB00053500-23
AB00053500-24
AB00053500-25
AB00053500_26
AB00053500_27
AB00053500_28
EN300-7370602
AE-641/01941016
Q410534
SR-01000000271-5
BRD-A82396632-001-03-0
BRD-A82396632-001-16-2
BRD-A82396632-008-02-7
BRD-A82396632-008-28-2
BRD-A82396632-008-29-0
1-[2,4dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole
1-[2,4-Dichloro-beta-([2,4-dichlorobenzyl]oxy)-phenethyl]imidazole
1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)-phenethyl]imidazole
1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-imidazole
1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole
Imidazole,4-dichloro-.beta.-[(2,4-dichlorobenzyl)oxy]phenethyl]-
1-[2,4-Dichloro-.beta.-[(2,4-dichlorobenzyl)oxy]phenethyl]imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole
1H-Imidazole,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-
Imidazole, 1-(2,4-dichloro-.beta.-((2,4-dichlorobenzyl)oxy)phenethyl)-
1-((2RS)-2-(2,4-Dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)-methoxy]ethyl]-1H-imidazole
1-[2-[(2,4-Dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole #
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)-
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
rac-1-(2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
245-324-5
75319-47-0
Monistat, Daktarin IV, Miconazolo, Miconazolum, Dactarin, Miconazol, Minostate, Brentan, Florid(nitrate)