Skip to main content

Perindopril

ADVERTISEMENT
Identification
Molecular formula
C19H32N2O5
CAS number
82834-16-0
IUPAC name
1-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid
State
State

In its dry form, perindopril is a solid compound. It is commonly used in oral administration in the form of tablets or capsules at room temperature. It is stable under normal conditions of use and storage.

Melting point (Celsius)
99.00
Melting point (Kelvin)
372.15
Boiling point (Celsius)
230.00
Boiling point (Kelvin)
503.15
General information
Molecular weight
368.47g/mol
Molar mass
368.4670g/mol
Density
1.0791g/cm3
Appearence

Perindopril is typically found in its salt form as perindopril erbumine. It appears as a white, crystalline powder. The substance is odorless or nearly odorless and may be hygroscopic, drawing moisture from the air.

Comment on solubility

Solubility of 1-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid (C19H32N2O5)

The solubility of this compound can be of great interest due to its complex structure and potential applications. Understanding its solubility characteristics can help in applications such as drug formulation and material design. Here are several key points regarding its solubility:

  • Solvent Dependence: The solubility may vary significantly depending on the solvent used. For organic compounds like this one, polar solvents often increase solubility due to favorable interactions.
  • pH Sensitivity: As a carboxylic acid, its solubility may be affected by pH changes in solution, as it can exist in protonated and deprotonated forms.
  • Temperature Effects: Generally, an increase in temperature tends to enhance solubility, allowing for better dissolution.
  • Hydrophobic and Hydrophilic Balance: The presence of both hydrophobic (phenyl group) and hydrophilic (carboxylic acid) parts of the molecule creates a complex solubility profile. The balance between these regions determines the overall solubility in various solvents.
  • Crystalline Structure: The molecular packing in the solid state will also play a role in solubility. Compounds with more ordered, crystalline structures tend to have lower solubility.

In conclusion, solubility is a multifaceted property influenced by various factors, and this compound showcases the intricate relationship between molecular structure and solubility behavior. Thus, further experimental data would be essential to determine its precise solubility profile in different conditions.

Interesting facts

Interesting Facts about 1-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid

This intricate compound is a notable example of a cyclopentapyrrole derivative, which presents unique therapeutic potentials in the field of medicinal chemistry. Here are some intriguing details about this fascinating compound:

  • Complex Structure: The compound showcases a complex multi-ring structure, which enhances its biological activity.
  • Biological Relevance: Compounds of this class are often investigated for their potential roles as antitumor agents, reflecting their activity against various cancer cell lines.
  • Pharmacophore Features: The presence of the carboxylic acid functional group may be crucial for binding interactions with biological targets, improving the compound's efficacy.
  • Synthetic Chemistries: The synthesis involves multiple steps, showcasing the skill and creativity of organic chemists in designing molecules with specific properties.
  • Potential for Modification: Due to its rich structure, there are numerous opportunities for structure-activity relationship (SAR) studies, where subtle modifications could lead to enhanced pharmacological properties.

In conclusion, this compound not only represents a significant molecular architecture but also opens doors to various therapeutic applications. As research progresses, it may unveil innovative treatments in the field of pharmaceutical sciences.

Synonyms
83508-17-2
Quark
(2R)-RaMipril
1-{2-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]propanoyl}-octahydrocyclopenta[b]pyrrole-2-carboxylic acid
SCHEMBL678408
CHEMBL1319316
DTXSID40861096
HDACQVRGBOVJII-UHFFFAOYSA-N
HMS3372B01
HMS3373I08
HMS3393E04
HMS3655I12
Cyclopenta[b]pyrrole-2-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, [2S-[1[R*(R*)],2.alpha.,3a.beta.,6a.beta.]]-
HXC94103
AKOS030228639
AB07503
NCGC00095902-01
1-[2-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid
LS-15015
SY031735
DB-016350
EN300-296175
(2S,3aS,6aS)-1-[(S)-2-[[(S)-1-Ethoxy-1-oxo-4-phenyl-2-butyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic Acid
1-{2-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]propanoyl}-octahydrocyclopenta[b]pyrrole-2-carboxylicacid
1-{2-[(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino]propanoyl}octahydrocyclopenta[b]pyrrole-2-carboxylic acid
Cyclopenta(b)pyrrole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl), (2S-(1(R*(R*)),2.alpha.,3a.beta.,6a.beta.))-