Propranolol

Identification

Molecular formula

C₁₆H₂₁NO₂

CAS number

525-66-6

IUPAC name

1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol

State

At room temperature, propranolol is in a solid state. Given its crystalline form, it is often handled and stored in dry conditions to maintain its stability and efficacy.

Melting point (Celsius)

96.00

Melting point (Kelvin)

369.15

Boiling point (Celsius)

368.00

Boiling point (Kelvin)

641.15

General information

Molecular weight

259.35g/mol

Molar mass

259.3490g/mol

Density

1.0804g/cm³

Appearence

Propranolol appears as a white or off-white crystalline powder. It is odorless and has a bitter taste. The crystalline nature of the powder is uniform, and it is typically used in its hydrochloride salt form for pharmaceutical purposes.

Comment on solubility

Solubility of 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol (C₁₆H₂₁NO₂)

The solubility of 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol is an intriguing aspect to consider, particularly given its unique molecular structure. Here are some key points regarding its solubility:

Polar Characteristics: Due to the presence of hydroxy (-OH) and amino (-NH) groups in the molecule, this compound tends to exhibit polar characteristics.
Solvent Interaction: It is likely to be soluble in polar solvents such as water and alcohols due to its ability to engage in hydrogen bonding.
Limited Non-Polar Solubility: Conversely, the presence of the large, hydrophobic indole group suggests limited solubility in non-polar solvents like hydrocarbons or alkane mixtures.
pH Dependence: The solubility may also vary with pH, as ionization of the amino group could enhance its solubility in more acidic or basic conditions.
Practical Implications: Understanding the solubility profile is crucial for applications in pharmaceuticals, where bioavailability can be significantly affected by solubility characteristics.

In summary, while this compound may have good solubility in polar environments, it is essential to consider the solvent nature and environmental factors to predict its behavior in various applications.

Interesting facts

Interesting Facts About 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol

1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol is a fascinating compound that bridges the realms of medicinal chemistry and biochemistry. Here are some intriguing points about this compound:

Indole Derivative: The structure of this compound includes an indole ring, which is known for its presence in various natural products and pharmaceuticals. This heterocyclic compound often contributes to the biological activity of many important compounds.
Biological Significance: Compounds with indole structures have been extensively studied for their potential antidepressant and anti-inflammatory properties. They interact with several neurotransmitter receptors, making them vital in neurological research.
Amine Functionality: The isopropylamino group within this compound plays a crucial role in influencing the physicochemical properties and biological activity. Amines often serve as key players in drug development due to their ability to form hydrogen bonds and interact with various receptors.
Pharmacophore: This compound represents a specific pharmacophore that may be effective in designing novel therapeutic agents. Its complex structure allows for fine-tuning of activity towards a given target protein or pathway.

Research into such compounds continues to yield promising results in the field of drug discovery and development. As scientists delve deeper into the mechanisms of action for compounds like 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol, we may uncover new treatments and therapies for various diseases. The ongoing exploration of indole derivatives highlights the importance of structural diversity in creating impactful pharmacological agents.

Synonyms

pindolol

13523-86-9

Visken

Betapindol

Prinodolol

Carvisken

Durapindol

Pinbetol

Calvisken

Decreten

Pectobloc

Pynastin

Blocklin L

Glauco-visken

LB-46

Pindololum

Blocklin-L

DL-Pindolol

Glauco-Viskin

Blockin L

(+-)-Pindolol

(rs)-pindolol

LB 46

Apo-pindol

4-(2-Hydroxy-3-isopropylaminopropoxy)-indole

1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol

Pindololum [INN-Latin]

1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol

CCRIS 9215

1-((1-Methylethyl)amino)-3-(4-indolyloxy)-2-propanol

1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol

HSDB 6539

Dl-lb-46

UNII-BJ4HF6IU1D

BJ4HF6IU1D

1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol

EINECS 236-867-9

EINECS 244-623-8

4-(3-(Isopropylamino)-2-hydroxypropoxy)indole

NSC-757276

1-(1H-Indol-4-yloxy)-3-((1-methylethyl)amino)-2-propanol

BRN 1536506

CHEBI:8214

2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-

DTXSID8023476

2-Propanol, 1-(1H-indol-4-yloxy)-3-((1-methylethyl)amino)-

2-Propanol, 1-(4-indolyloxy)-3-(isopropylamino)-

(+/-)-PINDOLOL

1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)-propan-2-ol

DTXCID603476

1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]propan-2-ol

Prindolol

2-Propanol, 1-(1H-indol-4-yloxy)-3-(1-methylethyl)amino-

VISKAZIDE COMPONENT PINDOLOL

5-21-03-00017 (Beilstein Handbook Reference)

Pindolol [USAN:USP:INN:BAN:JAN]

NSC 757276

NCGC00015786-11

1-(1H-indol-4-yloxy)-3-[(propan-2-yl)amino]propan-2-ol

Pindololum (INN-Latin)

PINDOLOL (MART.)

PINDOLOL [MART.]

(+/-)-LB-46

PINDOLOL (USP-RS)

PINDOLOL [USP-RS]

DL-4-[2-Hydroxy-3-(isopropylamino)propoxy]indole

4-(2-HYDROXY-3-ISOPROPYLAMINOPROPOXY)INDOLE

PINDOLOL (EP MONOGRAPH)

PINDOLOL [EP MONOGRAPH]

PINDOLOL (USP MONOGRAPH)

PINDOLOL [USP MONOGRAPH]

Blocklin

N-(2-HYDROXY-3-(1H-INDOL-4-YLOXY)PROPYL)-N-ISOPROPYLAMINE

Pindolol (USAN:USP:INN:BAN:JAN)

Carvisken (TN)

SMR000059120

Blocklin-L (TN)

Visken (TN)

SR-01000000027

pindololo

1-(1H-indol-4-yloxy)-3-((propan-2-yl)amino)propan-2-ol

DL-4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)INDOLE

1-(1H-indol-4-yloxy)-3-((1-methylethyl)amino)propan-2-ol

DL-LB 46

Prestwick_397

CAS-13523-86-9

Pindolol (Standard)

1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol

Spectrum_001109

(-)-Pindolol; (S)-(-)-Pindolol; S-Pindolol

(1)-1-(1H-Indol-4-yloxy)-3-(isopropylamino)propan-2-ol

PINDOLOL [HSDB]

PINDOLOL [USAN]

PINDOLOL [INN]

PINDOLOL [JAN]

PINDOLOL [MI]

PINDOLOL [VANDF]

(.+/-.)-Pindolol

Prestwick0_000090

Prestwick1_000090

Prestwick2_000090

Prestwick3_000090

Spectrum2_001285

Spectrum3_000547

Spectrum4_000479

Spectrum5_001266

CHEMBL500

GTPL91

PINDOLOL [WHO-DD]

PINDOLOL,(-)

P 0778

SCHEMBL5219

Lopac0_000955

Oprea1_770884

BSPBio_000020

BSPBio_002193

KBioGR_000958

KBioSS_001589

MLS000069496

MLS002548891

DivK1c_000837

SPECTRUM1500488

Pindolol (JP18/USP/INN)

SPBio_001289

SPBio_001959

PINDOLOL [ORANGE BOOK]

2-Propanol, 1-(indol-4-yloxy)-3-(isopropylamino)-

BPBio1_000022

1-((1H-indol-4-yl)oxy)-3-(isopropylamino)propan-2-ol

HMS502J19

HY-B0982R

KBio1_000837

KBio2_001589

KBio2_004157

KBio2_006725

KBio3_001693

C07AA03

NINDS_000837

2-Propanol, 1-(indol-4-yloxy)-3-(isopropylamino)-, (+-)-

HMS1568A22

HMS1920H16

HMS2089I21

HMS2091P20

HMS2095A22

HMS3259I07

HMS3262P12

HMS3267K17

HMS3369E14

HMS3414J03

HMS3678H21

HMS3712A22

HMS3742C07

HMS3885N04

Pharmakon1600-01500488

HY-B0982

Pindolol, >=98% (TLC), powder

Tox21_110221

Tox21_500955

BDBM50019443

CCG-39223

MFCD00010530

NSC757276

PDSP1_000771

PDSP1_000772

PDSP2_000759

PDSP2_000760

AKOS015969756

PINDOLOL COMPONENT OF VISKAZIDE

Tox21_110221_1

CS-4473

DB00960

LP00955

NC00467

SB17015

SDCCGSBI-0050929.P005

IDI1_000837

NCGC00015786-06

NCGC00015786-07

NCGC00015786-08

NCGC00015786-09

NCGC00015786-10

NCGC00015786-13

NCGC00015786-14

NCGC00015786-16

NCGC00015786-20

NCGC00015786-22

NCGC00024925-03

NCGC00024925-04

NCGC00024925-05

NCGC00024925-06

NCGC00024925-07

NCGC00261640-01

BS-42390

DA-66729

SBI-0050929.P004

4-(3-Isopropylamino-2-hydroxypropoxy)indole

AB00052072

EU-0100955

NS00007947

SW196641-3

C07445

C90604

D00513

AB00052072-11

AB00052072_12

AB00052072_13

1-(4-Indolyloxy)-3-(isopropylamino)-2-propanol

EN300-18518413

L000006

Q418101

SR-01000000027-2

SR-01000000027-4

SR-01000000027-5

SR-01000000027-7

1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol

BRD-A97701745-001-05-3

BRD-A97701745-001-09-5

BRD-A97701745-001-14-5

BRD-A97701745-001-15-2

BRD-A97701745-001-16-0

1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol #

Pindolol, European Pharmacopoeia (EP) Reference Standard

(+/-)-4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)INDOLE

1-(1H-Indol-4-yloxy)-3-)(1-methylethyl)amino)-2-propanol

1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol(pindolol)

Pindolol, United States Pharmacopeia (USP) Reference Standard

(2RS)-1-(1H-Indol-4-yloxy)-3-(1-methylethyl)aminopropan-2-ol

1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol((-)-Pindolol)

236-867-9

Solubility of 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol (C16H21NO2)

Interesting Facts About 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol

Solubility of 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol (C₁₆H₂₁NO₂)