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Glutathione

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Identification
Molecular formula
C20H32N6O12S2
CAS number
70-18-8
IUPAC name
1-[19-amino-7-(2-amino-2-oxo-ethyl)-10-(3-amino-3-oxo-propyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[5-amino-1-[(2-amino-2-oxo-ethyl)carbamoyl]pentyl]pyrrolidine-2-carboxamide
State
State

Glutathione is typically found as a solid under standard conditions. It is stable at room temperature and can exist as a stable white powder.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
307.32g/mol
Molar mass
307.3230g/mol
Density
1.3790g/cm3
Appearence

Glutathione is a white crystalline powder. It may also appear as a colorless crystalline or fluffy powder.

Comment on solubility

Solubility of 1-[19-amino-7-(2-amino-2-oxo-ethyl)-10-(3-amino-3-oxo-propyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[5-amino-1-[(2-amino-2-oxo-ethyl)carbamoyl]pentyl]pyrrolidine-2-carboxamide

The solubility of this complex compound, C20H32N6O12S2, can be influenced by several factors:

  • Polarity: Due to its numerous functional groups, including amino and carboxamide, the compound is likely to exhibit polar characteristics, which can enhance solubility in polar solvents like water.
  • Hydrophobic Groups: The presence of certain hydrophobic aromatic structures may limit solubility in non-polar solvents, leading to a complex solubility profile.
  • pH Dependence: The ionizable functional groups (such as amino groups) might behave differently across varying pH levels, further impacting solubility.

As a general principle, it's important to consider:

  1. "Like dissolves like" - Polar compounds tend to dissolve well in polar solvents.
  2. The molecular weight and size may also restrict solubility, particularly in aqueous solutions.
  3. Interactions with solvents (such as hydrogen bonding) will play a vital role in solubility dynamics.

In summary, the solubility of this compound is expected to be quite variable, reflecting its structural complexity and the interplay of its physicochemical properties. Further experimental studies would be required to ascertain exact solubility metrics in various solvents.

Interesting facts

Interesting Facts About the Compound

The compound, known for its complex structure and remarkable properties, showcases the fascinating world of chemistry. Here are some intriguing aspects:

  • Multifunctional Potential: This compound contains multiple functional groups, including amines and carbonyls, which suggest a wide range of biological activities. Its diverse chemical behavior makes it a candidate for drug design, especially in areas like pharmacology.
  • Structural Uniqueness: The incorporation of five nitrogen atoms in its cyclic structure contributes to its stability and reactivity. Such cyclic compounds often exhibit interesting conformational characteristics that can influence their interaction with biological molecules.
  • Applicability in Medicine: Due to the presence of amino groups, the compound may be investigated for its efficacy as a therapeutic agent. Researchers are continually exploring compounds with amino functionalities for their potential to treat various diseases.
  • Research Opportunities: With its complex arrangement of dithia and pentazacyclic motifs, this compound encourages the exploration of synthetic pathways for generating similar molecules, pushing the boundaries of organic synthesis.
  • Interdisciplinary Interest: The compound can attract interest from multiple fields, including organic chemistry, medicinal chemistry, and materials science. Its unique features may lead to innovative uses beyond traditional applications.

As with many complex compounds, the synthesis and characterization of this molecule can offer challenging yet rewarding experiences for chemistry students and researchers alike. Understanding such compounds not only enhances our grasp of chemical principles but also deepens our appreciation of the diverse functions that molecules can perform in the realm of life sciences.

Synonyms
8-L-Lysine vasopressin
CHEBI:6603
Lys-vasopressin
NCGC00181743-01
NCGC00181743-02
Lypressin (USAN/INN)
DIAPID (TN)
SCHEMBL1650587
CHEMBL1991816
BJFIDCADFRDPIO-UHFFFAOYSA-N
C07105
D00366
Q27107266
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 [Disulfide Bridge: 1-6]