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Trimeprazine

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Identification
Molecular formula
C18H22N2OS
CAS number
84-96-8
IUPAC name
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
State
State

Trimeprazine is generally found as a solid at room temperature. It is often provided in its salt forms for medical use, including either as tartrate or maleate salts, both of which are also solid powders.

Melting point (Celsius)
62.00
Melting point (Kelvin)
335.15
Boiling point (Celsius)
358.50
Boiling point (Kelvin)
631.65
General information
Molecular weight
295.45g/mol
Molar mass
295.4210g/mol
Density
1.0900g/cm3
Appearence

Trimeprazine appears as a pale yellow crystalline powder. It is hygroscopic in nature and can absorb moisture from the environment. The compound has a faint amine-like odor.

Comment on solubility

Solubility of 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one

The solubility of the compound 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one (C18H22N2OS) can be analyzed based on its chemical structure and functional groups. Typically, compounds with complex structures, like this one, usually exhibit interesting solubility characteristics:

  • Polarity: The presence of a dimethylamino group suggests the potential for polar interactions, which may enhance solubility in polar solvents.
  • Hydrophobic character: The phenothiazine part of the molecule indicates a certain degree of hydrophobicity, which can limit solubility in water but enhance it in organic solvents.
  • Solvent interactions: This compound is likely to be soluble in solvents such as ethanol and methanol, while showing limited solubility in water due to the hydrophobic regions.
  • pH effects: The solubility may also depend on the pH of the solution, as changes in ionization state of the dimethylamino group can significantly influence solubility.

In summary, we can expect 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one to exhibit a unique solubility profile, being more soluble in organic solvents but less so in aqueous solutions due to its hybrid character. Proper selection of the solvent will be crucial for applications involving this compound.

Interesting facts

Exploring 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one

1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one is a fascinating compound that combines elements from the realms of medicinal chemistry and organic synthesis. This intriguing molecule belongs to the phenothiazine class, which is known for its wide array of biological activities.

Biological Significance

This compound exhibits a range of properties that make it a subject of considerable interest in pharmacology:

  • Antipsychotic Activities: Similar to other compounds in the phenothiazine family, it may interact with neurotransmitter receptors, potentially having antipsychotic effects.
  • Antimicrobial Properties: There are ongoing studies investigating its efficacy against various pathogens, which suggests potential applications in treating infections.
  • Neuroprotective Effects: Some research indicates compounds like this may help protect neuronal health, thus opening avenues for treating neurodegenerative diseases.

Chemical Characteristics

The structure of this compound is noteworthy due to its:

  • Dimethylamino Group: This moiety is known for enhancing the lipophilicity of compounds, which can aid in crossing biological membranes.
  • Unique Linkages: The combination of the propan-1-one framework with the phenothiazine core may lead to intricate interactions within biological systems.

Research and Development

Scientific exploration of this compound involves:

  • Synthetic Routes: Chemists are continuously developing novel methods for its synthesis, making it vital in advancing organic chemistry methodologies.
  • Drug Development: As a derivative of phenothiazine, it is studied for its potential to be developed into safer and more effective therapeutic agents.

This compound represents the intricate world of chemical research where diverse properties and potential applications converge. Its ongoing study is a testament to the ever-evolving field of medicinal chemistry, as scientists strive to unlock the secrets of such multifaceted molecules.

Synonyms
propiomazine
362-29-8
Propionylpromethazine
Phenoctyl
Propiomazina
Propiomazinum
Wy-1359
Propiomazinum [INN-Latin]
Propiomazina [INN-Spanish]
Propiomazine [USAN:INN:BAN]
CB 1678
2-Propionyl-10-(2-(dimethylamino)propyl)phenothiazine
3-Propionyl-10-dimethylaminoisopropylphenothiazine
10-(2-Dimethylaminopropyl)-2-propionylphenothiazine
Dorevan
HSDB 3275
EINECS 206-646-1
1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}propan-1-one
CB-1678
CHEBI:8491
10-Dimethylaminoisopropyl-2-propionylphenothiazine
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
242Z0PM79Y
PROPIOMAZINE [MI]
PROPIOMAZINE [INN]
1-(10-(2-(Dimethylamino)propyl)phenothiazin-2-yl)-1-propanone
PROPIOMAZINE [HSDB]
PROPIOMAZINE [USAN]
PROPIOMAZINE [VANDF]
1-Propanone, 1-(10-(2-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-
PROPIOMAZINE [MART.]
(+/-)-PROPIOMAZINE
PROPIOMAZINE [WHO-DD]
DTXSID1023520
1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone
1-Propanone, 1-(10-(2-(dimethylamino)propyl)phenothiazin-2-yl)-
1-Propanone, 1-[10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-
Propiomazinum (INN-Latin)
Propiomazina (INN-Spanish)
PROPIOMAZINE (MART.)
1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl]-1-propanone
1-[10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]-1-propanone
2-Propionyl-10-[2-(dimethylamino)propyl]phenothiazine
Propiomazine (USAN/INN)
Propiomazin
Serentin
UNII-242Z0PM79Y
1-Propanone, 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]-
1-(10-(2-(dimethylamino)propyl)-10H-phenothiazin-2-yl)propan-1-one
1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}-1-propanone
Propiomazine Free Base
Spectrum_000872
Spectrum2_000930
Spectrum3_000559
Spectrum4_000491
Spectrum5_001104
Oprea1_617420
SCHEMBL93770
BSPBio_002237
KBioGR_001001
KBioSS_001352
DivK1c_000296
SPBio_000840
DTXCID903520
GTPL7284
CHEMBL1201210
KBio1_000296
KBio2_001352
KBio2_003920
KBio2_006488
KBio3_001737
N05CM06
NINDS_000296
HY-U00051
DB00777
IDI1_000296
NCGC00178744-01
DA-57112
CS-0021941
NS00021133
NS00125832
C07405
D02361
EN300-18559874
L000807
Q7250328
BRD-A10471441-050-02-8
206-646-1