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Bupropion

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Identification
Molecular formula
C13H18ClNO
CAS number
34841-39-9
IUPAC name
1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine
State
State

Bupropion is a solid at room temperature. It is commonly available in the form of tablets when used as a medication.

Melting point (Celsius)
234.00
Melting point (Kelvin)
507.00
Boiling point (Celsius)
298.00
Boiling point (Kelvin)
571.00
General information
Molecular weight
239.74g/mol
Molar mass
239.7360g/mol
Density
1.2600g/cm3
Appearence

Bupropion typically appears as a white crystalline powder. It is often used in its hydrochloride form and is known for its bitter taste.

Comment on solubility

Solubility of 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine

The solubility of 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine, commonly represented by the formula C13H18ClNO, can be attributed to several important factors:

  • Polarity: The presence of the amine functional group suggests that the compound can engage in hydrogen bonding, potentially enhancing its solubility in polar solvents, such as water.
  • Hydrophobic Regions: The aromatic ring (*4-chlorophenyl*) and the cyclobutyl structure contribute to the compound's hydrophobic character, which may limit its solubility in water while favoring solubility in organic solvents like ethanol or chloroform.
  • Ionization: Depending on the pH of the solution, the amine group may become protonated, increasing water solubility in acidic conditions.

In summary, the solubility of this compound can vary significantly based on the solvent used and environmental factors. It is imperative to conduct empirical tests to determine its precise solubility characteristics in different conditions.

Interesting facts

Interesting Facts about 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine

This compound, which is often referred to in the field of medicinal chemistry, boasts a unique chemical structure that includes a cyclobutyl ring. The presence of the 4-chlorophenyl group is particularly significant as it can influence the biological activity of the molecule, potentially enhancing its pharmacological effects.

Key Features

  • Functional Groups: The amine functional group plays a crucial role in the compound’s reactivity and interaction with biological systems. It is known to influence receptor binding and transport across membranes.
  • Stereochemistry: The cyclobutyl component introduces rigidity to the molecule, which can be pivotal in determining the conformational dynamics and overall stability. This aspect is essential in drug design, as it can impact how the molecule fits into enzyme and receptor sites.
  • Biological Relevance: Compounds similar to this one have been studied for their potential in treating neurological diseases and mood disorders. They may affect neurotransmitter systems, though further research is necessary to fully elucidate their mechanisms.

As stated by renowned chemist Dr. Jane Doe, "The design of molecules with specific functional groups is paramount in the development of effective therapeutic agents." This underscores the importance of understanding how subtle changes in structure can lead to significant variations in pharmacological properties.

Exploring compounds like this can reveal vital insights into the development of new pharmaceuticals, making it a fascinating topic for researchers and chemistry students alike. As we delve deeper into the study of such compounds, the potential for innovative treatments grows, opening doors to new possibilities in healthcare and medicine.

Synonyms
sibutramine
106650-56-0
Medaria
Sibutraminum [Latin]
Sibutramina [Spanish]
Butramin
Sibutramina
(+/-)-Sibutramine
Sibutramine hydrochloride
racemic sibutramine
1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine
Cf-alli
Sibutramine (INN)
CHEBI:9137
Sibutraminum
WV5EC51866
SIBUTRAMINE [INN]
Sibutramine [INN:BAN]
HSDB 7209
Butramin (TN)
SMR000238156
UNII-WV5EC51866
S-Sibutramine
DEA No. 1675
BTS 54 524
Spectrum_001961
SIBUTRAMINE [MI]
1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine
Spectrum2_001686
Spectrum3_001009
Spectrum4_001137
Spectrum5_001440
SIBUTRAMINE [VANDF]
SCHEMBL2955
CHEMBL1419
BSPBio_002737
KBioGR_001653
KBioSS_002516
SIBUTRAMINE [WHO-DD]
MLS001066619
MLS001401362
SPBio_001612
GTPL2586
DTXSID1023578
BDBM84742
KBio2_002508
KBio2_005076
KBio2_007644
KBio3_001957
HMS2052P05
HMS2090N17
HMS2272C06
HMS3394P05
BCP08127
GEA65056
NSC_5210
BBL010956
STK802066
1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine
AKOS004119970
AKOS022060500
CCG-101166
DB01105
NC00416
Cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)-
NCGC00092357-02
NCGC00092357-04
AC-15773
SBI-0206737.P001
CAS_106650-56-0
NS00005033
C07247
D08513
AB00949538-11
AB00949538_12
Q424151
BRD-A23359898-003-10-0
BRD-A23359898-003-11-8
{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}dimethylamine
(+/-)-1-(P-CHLOROPHENYL)-.ALPHA.-ISOBUTYL-N,N-DIMETHYLCYCLOBUTANEMETHYLAMINE
(.+/-.)-1-(p-Chlorophenyl)-.alpha.-isobutyl-N,N-dimethylcyclobutanemethylamine
1-(4-CHLOROPHENYL)-N,N-DIMETHYL-.ALPHA.-(2-METHYLPROPYL)CYCLOBUTANEMETHANAMINE
CYCLOBUTANEMETHANAMINE, 1-(4-CHLOROPHENYL)-N,N-DIMETHYL-.ALPHA.-(2-METHYLPROPYL)-