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Bortezomib

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Identification
Molecular formula
C19H25BN4O4
CAS number
179324-69-7
IUPAC name
[1-[[1-[2-[[hydroxy(morpholino)methyl]amino]-3,3-diphenyl-propanoyl]pyrrole-2-carbonyl]amino]-4-methoxy-butyl]boronic acid
State
State

At room temperature, Bortezomib is typically in a solid state as a powder. It is sensitive to moisture and requires careful handling to ensure stability.

Melting point (Celsius)
122.00
Melting point (Kelvin)
395.15
Boiling point (Celsius)
227.00
Boiling point (Kelvin)
500.15
General information
Molecular weight
384.24g/mol
Molar mass
384.2360g/mol
Density
1.3000g/cm3
Appearence

Bortezomib appears as a white to off-white crystalline powder. It is typically used in its mannitol ester form, which dissolves into a clear solution for medical applications.

Comment on solubility

Solubility of 1-[[1-[2-[[hydroxy(morpholino)methyl]amino]-3,3-diphenyl-propanoyl]pyrrole-2-carbonyl]amino]-4-methoxy-butyl]boronic acid (C19H25BN4O4)

The solubility profile of 1-[[1-[2-[[hydroxy(morpholino)methyl]amino]-3,3-diphenyl-propanoyl]pyrrole-2-carbonyl]amino]-4-methoxy-butyl]boronic acid is quite fascinating due to its complex structure and functional groups. Understanding its solubility can provide insights into its potential applications in various fields. Here are some key points to consider:

  • Polar and Non-Polar Characteristics: The presence of boronic acid, morpholine, and multiple aromatic rings suggests that this compound may exhibit a mix of polar and non-polar properties. This dual nature can influence its solubility in different solvents.
  • Water Solubility: While boronic acids often show some degree of solubility in water, the extensive carbon structures and hydrophobic components might limit its solubility. Thus, it may be expected to have moderate to low water solubility.
  • Organic Solvents: This compound is likely more soluble in organic solvents such as DMSO (dimethyl sulfoxide) or methanol due to the large hydrophobic sections. As “like dissolves like,” polar solvents may favor solubility due to the presence of polar functional groups.
  • pH Dependency: The solubility might also be influenced by the pH of the solution, as the boronic acid group can exist in different protonation states depending on the acidity of the medium. This could allow for increased solubility under certain conditions, particularly in more alkaline solutions.

In summary, 1-[[1-[2-[[hydroxy(morpholino)methyl]amino]-3,3-diphenyl-propanoyl]pyrrole-2-carbonyl]amino]-4-methoxy-butyl]boronic acid demonstrates complex solubility characteristics, influenced by its multifaceted chemical structure, leading to variable solubility in both polar and non-polar environments.

Interesting facts

Exploring the Unique Properties of 1-[[1-[2-[[hydroxy(morpholino)methyl]amino]-3,3-diphenyl-propanoyl]pyrrole-2-carbonyl]amino]-4-methoxy-butyl]boronic acid

The compound 1-[[1-[2-[[hydroxy(morpholino)methyl]amino]-3,3-diphenyl-propanoyl]pyrrole-2-carbonyl]amino]-4-methoxy-butyl]boronic acid is a striking example of modern organic chemistry, showcasing an intriguing combination of functional groups and structural features. Here are some interesting facts that highlight its significance:

  • Boronic Acid Feature: The inclusion of a boronic acid group makes this compound a potential candidate for *cross-coupling reactions*, a fundamental strategy in organic synthesis that enables the formation of carbon-carbon bonds.
  • Therapeutic Potential: Compounds with *morpholino* moieties are often explored in medicinal chemistry, especially for their utility in drug design. The unique structure may enhance bioavailability or target specificity.
  • Bioconjugation: The presence of multiple amine and carbonyl groups allows for potential bioconjugation, paving the way for applications in drug delivery systems or as probes in biological research.
  • Versatility: The diverse functional groups within the structure suggest a wide range of possible reactivity, which could make this compound useful in the development of novel materials or therapeutic agents.

To quote an old adage in chemistry: "Every compound tells a story." The complexity of this molecule allows us to investigate its *mechanistic pathways* and *interactions* in greater detail, reinforcing the idea that behind each synthesis lies a myriad of potential applications. As we delve into its synthesis and reactivity, we continue to uncover the endless possibilities that organic chemistry has to offer.