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Bortezomib

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Identification
Molecular formula
C19H25BN4O4
CAS number
179324-69-7
IUPAC name
[1-[[1-(2-amino-3-phenyl-propanoyl)pyrrolidine-2-carbonyl]amino]-2-(3-cyanophenyl)ethyl]boronic acid
State
State

Solid at room temperature.

Melting point (Celsius)
122.00
Melting point (Kelvin)
395.15
Boiling point (Celsius)
643.90
Boiling point (Kelvin)
917.05
General information
Molecular weight
384.24g/mol
Molar mass
384.2440g/mol
Density
1.2900g/cm3
Appearence

Bortezomib is a white to off-white crystalline powder.

Comment on solubility

Solubility of 1-[[1-(2-amino-3-phenyl-propanoyl)pyrrolidine-2-carbonyl]amino]-2-(3-cyanophenyl)ethyl]boronic acid

The solubility of the compound 1-[[1-(2-amino-3-phenyl-propanoyl)pyrrolidine-2-carbonyl]amino]-2-(3-cyanophenyl)ethyl]boronic acid (C19H25BN4O4) presents some intriguing characteristics due to its unique structural composition. Generally, the solubility of a compound is influenced by factors including its polarity, molecular weight, and the presence of functional groups.

Factors Influencing Solubility:

  • Polarity: The presence of polar functional groups, such as the boronic acid moiety, can enhance the compound's solubility in polar solvents.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds can significantly increase its solubility in water, particularly if it contains amine or hydroxyl groups.
  • Molecular Weight: Higher molecular weight can sometimes hinder solubility, but the structural features can mitigate this effect.
  • pH Sensitivity: The ionization state of the boronic acid can vary with pH, which affects its solubility in aqueous solutions.

In many cases, while the solubility of boronic acids tends to be relatively low in organic solvents, they often exhibit better solubility in water due to hydrophilic interactions. Therefore, this specific compound may be expected to have some level of water solubility, although experimental data would be necessary for precise quantification. As with many compounds, it is always essential to consider the exact conditions (e.g., temperature, presence of other solutes) when discussing solubility.

Interesting facts

Interesting Facts about 1-[[1-(2-amino-3-phenyl-propanoyl)pyrrolidine-2-carbonyl]amino]-2-(3-cyanophenyl)ethyl]boronic acid

This fascinating compound plays a pivotal role in several fields of chemistry and pharmaceuticals. Its unique structure, characterized by multiple functional groups, allows it to interact with biological systems in intriguing ways. Here are some key points to note:

  • Versatile Reactivity: The presence of a boronic acid group makes this compound highly reactive, especially in the formation of covalent bonds with diols and other nucleophiles, paving the way for valuable applications in organic synthesis.
  • Potential Drug Development: Given its complex structure, this compound may serve as a lead compound in drug development, particularly for targeting specific biological pathways. Research into its pharmacological properties could reveal new therapeutic avenues.
  • Bioconjugation: The reactive boronic acid moiety allows it to be used in bioconjugation processes. This is crucial in the development of drug delivery systems and targeted therapies, where precision is key.
  • Structure Activity Relationship (SAR): Chemists can explore variations in the compound's structure to optimize biological activity, allowing for a deeper understanding of how modifications can alter efficacy and selectivity.
  • Educational Insights: For chemistry students, this compound provides a rich context for studying concepts like organic synthesis, functional group reactivity, and the principles of drug design.

In summary, 1-[[1-(2-amino-3-phenyl-propanoyl)pyrrolidine-2-carbonyl]amino]-2-(3-cyanophenyl)ethyl]boronic acid is not just a compound, but a gateway to discovering new chemical reactivity and therapeutic potentials in modern science. As always, the interplay between structure and function remains key in the exciting world of chemistry!

Synonyms
SCHEMBL8260155
PD036145