Skip to main content

Clotrimazole

ADVERTISEMENT
Identification
Molecular formula
C22H17ClN2O
CAS number
23593-75-1
IUPAC name
1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]vinyl]imidazole
State
State

The compound is a solid at room temperature and is essentially insoluble in water but soluble in organic solvents such as ethanol and acetone.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.15
Boiling point (Celsius)
546.10
Boiling point (Kelvin)
819.25
General information
Molecular weight
344.84g/mol
Molar mass
344.8430g/mol
Density
1.2360g/cm3
Appearence

Clotrimazole appears as a white to pale yellow crystalline powder. It is essentially odorless and exhibits a melting point characteristic of pure crystalline substances.

Comment on solubility

Solubility of 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]vinyl]imidazole

The solubility of the compound 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]vinyl]imidazole (C22H17ClN2O) can be influenced by several factors due to its intricate structure. Understanding its solubility is vital for its potential applications in pharmaceuticals and agrochemicals.

Factors influencing solubility:

  • Polarity: The presence of both polar and non-polar functional groups in the compound can result in varied solubility in different solvents.
  • Hydrogen bonding: The imidazole ring can participate in hydrogen bonding, which affects its interaction with solvent molecules.
  • Structural symmetry: The symmetrical nature of the phenyl groups may enhance solubility in organic solvents.

In general, compounds with similar polarity to the solvent tend to dissolve better, in line with the principle of "like dissolves like." Therefore, while this compound may show some solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO), it might exhibit low solubility in polar solvents like water. Furthermore, its solubility can be influenced by:

  • Temperature: Increased temperatures typically enhance solubility for many organic compounds.
  • pH levels: The pH of the environment may affect ionic interactions, particularly due to potential protonation of the imidazole nitrogen.

In conclusion, while the exact solubility of 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]vinyl]imidazole can vary significantly based on external conditions, its unique structural characteristics suggest it is more likely to be soluble in organic solvents rather than in aqueous solutions. Further experimental data would be essential to provide a precise solubility profile.

Interesting facts

Interesting Facts about 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]vinyl]imidazole

1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]vinyl]imidazole is a fascinating compound noteworthy for its unique structure and potential applications in various fields.

Chemical Structure

This compound features a complex architecture that includes:

  • An imidazole ring, which is a common motif found in many biologically active compounds.
  • A vinyl group, contributing to its reactivity and potential for polymerization.
  • A methoxy group attached to a phenyl ring, enhancing its lipophilicity.
  • A 3-chlorophenyl substituent, which can influence its biological activity and interaction with other molecules.

The intricate interplay of these components creates opportunities for unique interactions with biological systems.

Potential Applications

Research into compounds like this one suggests they may have various applications:

  • Pharmaceuticals: Due to the presence of the imidazole ring, this compound may exhibit anti-inflammatory or anticancer properties.
  • Material Science: The vinyl group can be useful for synthesizing advanced materials through polymer chemistry.
  • Analytical Chemistry: The compound could serve as a reagent in the detection of specific analytes given its reactivity.

Future Research Potential

Exploring 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]vinyl]imidazole further could unveil:

  • Synergistic properties with other chemical agents, expanding its utility in medical applications.
  • Mechanisms of action that reveal its effectiveness in targeting specific biological pathways.
  • New derivatives with enhanced properties for specialized uses.

In summary, this compound encapsulates a wealth of opportunities for scientific exploration and innovation. Its intriguing structure is a reminder of the complexity and potential that exists within the world of chemical compounds.

Synonyms
Croconazole
77175-51-0
Cloconazole
Croconazol
Croconazolum
Croconazole [INN]
viniconazole
Croconazolum [Latin]
1-(1-(2-((3-Chlorobenzyl)oxy)phenyl)vinyl)-1H-imidazole
Croconazol [French,Spanish]
Croconazole (INN)
1-(1-(o-((m-Chlorobenzyl)oxy)phenyl)vinyl)imidazole
UNII-446254H55G
CROCONAZOLE [MI]
1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]ethenyl]imidazole
CROCONAZOLE [WHO-DD]
CHEBI:3920
446254H55G
DTXSID6058475
Croconazolum (Latin)
1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]vinyl]imidazole
1H-Imidazole, 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]ethenyl]-
1-[1-[o-[(m-Chlorobenzyl)oxy]phenyl]vinyl]imidazole
1H-Imidazole, 1-(1-(2-((3-chlorophenyl)methoxy)phenyl)ethenyl)-
1-(1-(2-((3-CHLOROPHENYL)METHOXY)PHENYL)ETHENYL)-1H-IMIDAZOLE
C18H15ClN2O
1-(1-(2-((3-chlorophenyl)methoxy)phenyl)vinyl)imidazole
SCHEMBL34369
CHEMBL27289
DTXCID4032243
AKOS016013970
AT42414
HY-17011
TS-10078
DB-056184
CS-0003833
NS00007407
D07752
Q5187423
BRD-K73701464-003-01-3
1-(1-(2-(3-chlorobenzyloxy)phenyl)vinyl)-1H-imidazole
1[1-2[(3-Chlorophenyl)methoxy]-phenyl]vinyl]-1H-imidazole
1H-Imidazole, 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]-
3-Chlorobenzyl 2-[1-(1H-imidazol-1-yl)vinyl]phenyl ether #